Comparison of recombinant human bone morphogenetic protein-2-infused absorbable collagen sponge, recombinant human bone morphogenetic protein-2-coated tricalcium phosphate, and platelet-rich fibrin-mixed tricalcium phosphate for sinus augmentation in rabbits
Background/purpose: Numerous grafting materials have been used in the bone regeneration of maxillary sinus to obtain a sufficient amount of new bone in implant dentistry. The objective of this study was to compare the potentials of Type I absorbable collagen sponge (ACS) impregnated with recombinant...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-09-01
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| Series: | Journal of Dental Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S199179021730034X |
| _version_ | 1818409467265417216 |
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| author | Chul-Hun Kim Mi-Ha Ju Bok-Joo Kim |
| author_facet | Chul-Hun Kim Mi-Ha Ju Bok-Joo Kim |
| author_sort | Chul-Hun Kim |
| collection | DOAJ |
| description | Background/purpose: Numerous grafting materials have been used in the bone regeneration of maxillary sinus to obtain a sufficient amount of new bone in implant dentistry. The objective of this study was to compare the potentials of Type I absorbable collagen sponge (ACS) impregnated with recombinant human bone morphogenetic protein (rhBMP)-2, rhBMP-2-coated tricalcium phosphate (TCP), platelet-rich fibrin-mixed TCP for enhancing bone regeneration in sinus augmentation in rabbits. Materials and methods: The sinus defects were grafted with rhBMP-2+ACS (Group A), rhBMP-2-coated TCP (Group B), and platelet-rich fibrin-mixed TCP (Group C). The specimens underwent decalcification, and were stained for histomorphometric analysis. Results: There were no significant differences in inflammatory features among the groups 1-week postoperation. In a histomorphometric analysis, the new bone formation ratio showed significant differences between groups at 2 weeks. rhBMP-2+ACS showed a larger and more rapid bone formation area at 2 weeks than those of Groups B and C. Conclusion: Our histological evaluation demonstrates that Type I ACS can be used as a carrier of rhBMP-2, and rhBMP-2+ACS showed rapid bone formation, remodeling, and calcification at Week 2 in rabbit. Keywords: absorbable collagen sponge, BMP-2, PRF, sinus augmentation, TCP |
| first_indexed | 2024-12-14T10:00:05Z |
| format | Article |
| id | doaj.art-1e5907e8fd7547929453bd9db0607a90 |
| institution | Directory Open Access Journal |
| issn | 1991-7902 |
| language | English |
| last_indexed | 2024-12-14T10:00:05Z |
| publishDate | 2017-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Dental Sciences |
| spelling | doaj.art-1e5907e8fd7547929453bd9db0607a902022-12-21T23:07:17ZengElsevierJournal of Dental Sciences1991-79022017-09-01123205212Comparison of recombinant human bone morphogenetic protein-2-infused absorbable collagen sponge, recombinant human bone morphogenetic protein-2-coated tricalcium phosphate, and platelet-rich fibrin-mixed tricalcium phosphate for sinus augmentation in rabbitsChul-Hun Kim0Mi-Ha Ju1Bok-Joo Kim2Department of Oral and Maxillofacial Surgery, Assistant Professor, Dong-a Univ. College of Medicine, Busan, South KoreaDepartment of Pathology, Faculty of Pathology, Dong-a University College of Medicine, Busan, South KoreaDepartment of Oral and Maxillofacial Surgery, Assistant Professor, Dong-a Univ. College of Medicine, Busan, South Korea; Corresponding author.Background/purpose: Numerous grafting materials have been used in the bone regeneration of maxillary sinus to obtain a sufficient amount of new bone in implant dentistry. The objective of this study was to compare the potentials of Type I absorbable collagen sponge (ACS) impregnated with recombinant human bone morphogenetic protein (rhBMP)-2, rhBMP-2-coated tricalcium phosphate (TCP), platelet-rich fibrin-mixed TCP for enhancing bone regeneration in sinus augmentation in rabbits. Materials and methods: The sinus defects were grafted with rhBMP-2+ACS (Group A), rhBMP-2-coated TCP (Group B), and platelet-rich fibrin-mixed TCP (Group C). The specimens underwent decalcification, and were stained for histomorphometric analysis. Results: There were no significant differences in inflammatory features among the groups 1-week postoperation. In a histomorphometric analysis, the new bone formation ratio showed significant differences between groups at 2 weeks. rhBMP-2+ACS showed a larger and more rapid bone formation area at 2 weeks than those of Groups B and C. Conclusion: Our histological evaluation demonstrates that Type I ACS can be used as a carrier of rhBMP-2, and rhBMP-2+ACS showed rapid bone formation, remodeling, and calcification at Week 2 in rabbit. Keywords: absorbable collagen sponge, BMP-2, PRF, sinus augmentation, TCPhttp://www.sciencedirect.com/science/article/pii/S199179021730034X |
| spellingShingle | Chul-Hun Kim Mi-Ha Ju Bok-Joo Kim Comparison of recombinant human bone morphogenetic protein-2-infused absorbable collagen sponge, recombinant human bone morphogenetic protein-2-coated tricalcium phosphate, and platelet-rich fibrin-mixed tricalcium phosphate for sinus augmentation in rabbits Journal of Dental Sciences |
| title | Comparison of recombinant human bone morphogenetic protein-2-infused absorbable collagen sponge, recombinant human bone morphogenetic protein-2-coated tricalcium phosphate, and platelet-rich fibrin-mixed tricalcium phosphate for sinus augmentation in rabbits |
| title_full | Comparison of recombinant human bone morphogenetic protein-2-infused absorbable collagen sponge, recombinant human bone morphogenetic protein-2-coated tricalcium phosphate, and platelet-rich fibrin-mixed tricalcium phosphate for sinus augmentation in rabbits |
| title_fullStr | Comparison of recombinant human bone morphogenetic protein-2-infused absorbable collagen sponge, recombinant human bone morphogenetic protein-2-coated tricalcium phosphate, and platelet-rich fibrin-mixed tricalcium phosphate for sinus augmentation in rabbits |
| title_full_unstemmed | Comparison of recombinant human bone morphogenetic protein-2-infused absorbable collagen sponge, recombinant human bone morphogenetic protein-2-coated tricalcium phosphate, and platelet-rich fibrin-mixed tricalcium phosphate for sinus augmentation in rabbits |
| title_short | Comparison of recombinant human bone morphogenetic protein-2-infused absorbable collagen sponge, recombinant human bone morphogenetic protein-2-coated tricalcium phosphate, and platelet-rich fibrin-mixed tricalcium phosphate for sinus augmentation in rabbits |
| title_sort | comparison of recombinant human bone morphogenetic protein 2 infused absorbable collagen sponge recombinant human bone morphogenetic protein 2 coated tricalcium phosphate and platelet rich fibrin mixed tricalcium phosphate for sinus augmentation in rabbits |
| url | http://www.sciencedirect.com/science/article/pii/S199179021730034X |
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