Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives
Matrine is a quinoline alkaloid extracted and separated from the dried root, fruit, and other parts of the plant <i>Sophora flavescens</i> using an organic solvent. Matrine exhibits a variety of biological activities and is widely used in pharmacy, agronomy, and other fields. Due to its...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/15/5780 |
| _version_ | 1797586291822428160 |
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| author | Jinlei Li Shijie Wei Davies Marabada Zhizhong Wang Qing Huang |
| author_facet | Jinlei Li Shijie Wei Davies Marabada Zhizhong Wang Qing Huang |
| author_sort | Jinlei Li |
| collection | DOAJ |
| description | Matrine is a quinoline alkaloid extracted and separated from the dried root, fruit, and other parts of the plant <i>Sophora flavescens</i> using an organic solvent. Matrine exhibits a variety of biological activities and is widely used in pharmacy, agronomy, and other fields. Due to its low bioavailability, poor chemical stability, and toxicity to the central nervous system, a large number of researchers have searched for matrine derivatives with higher biological activity and safety by modifying its structure. In this review article, the research progress of matrine derivatives obtained using two methods (extraction from <i>Sophora flavescens</i> and structural modifications) from 2018 to 2022 in terms of pharmacological activity, mechanism of action, and structure–activity relationship are presented. The modification of matrine over the past five years has been mainly on the D-ring. Many new matrine alkaloids have been extracted from natural products, some of which have good pharmacological activity, which broadens the strategy for matrine structural modification in the future. |
| first_indexed | 2024-03-11T00:20:14Z |
| format | Article |
| id | doaj.art-1e595ae7138047c1b2c055b9fd5c5e5b |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T00:20:14Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1e595ae7138047c1b2c055b9fd5c5e5b2023-11-18T23:18:47ZengMDPI AGMolecules1420-30492023-07-012815578010.3390/molecules28155780Research Progress of Natural Matrine Compounds and Synthetic Matrine DerivativesJinlei Li0Shijie Wei1Davies Marabada2Zhizhong Wang3Qing Huang4School of Pharmacy, Ningxia Medical University, Yinchuan 750004, ChinaPharmacy Department, General Hospital of Ningxia Medical University, Yinchuan 750004, ChinaSchool of Pharmacy, Ningxia Medical University, Yinchuan 750004, ChinaSchool of Pharmacy, Ningxia Medical University, Yinchuan 750004, ChinaSchool of Pharmacy, Ningxia Medical University, Yinchuan 750004, ChinaMatrine is a quinoline alkaloid extracted and separated from the dried root, fruit, and other parts of the plant <i>Sophora flavescens</i> using an organic solvent. Matrine exhibits a variety of biological activities and is widely used in pharmacy, agronomy, and other fields. Due to its low bioavailability, poor chemical stability, and toxicity to the central nervous system, a large number of researchers have searched for matrine derivatives with higher biological activity and safety by modifying its structure. In this review article, the research progress of matrine derivatives obtained using two methods (extraction from <i>Sophora flavescens</i> and structural modifications) from 2018 to 2022 in terms of pharmacological activity, mechanism of action, and structure–activity relationship are presented. The modification of matrine over the past five years has been mainly on the D-ring. Many new matrine alkaloids have been extracted from natural products, some of which have good pharmacological activity, which broadens the strategy for matrine structural modification in the future.https://www.mdpi.com/1420-3049/28/15/5780matrine<i>Sophora flavescens</i>structural modificationmatrine derivativesmatrine-type alkaloidsbiological activity |
| spellingShingle | Jinlei Li Shijie Wei Davies Marabada Zhizhong Wang Qing Huang Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives Molecules matrine <i>Sophora flavescens</i> structural modification matrine derivatives matrine-type alkaloids biological activity |
| title | Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives |
| title_full | Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives |
| title_fullStr | Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives |
| title_full_unstemmed | Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives |
| title_short | Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives |
| title_sort | research progress of natural matrine compounds and synthetic matrine derivatives |
| topic | matrine <i>Sophora flavescens</i> structural modification matrine derivatives matrine-type alkaloids biological activity |
| url | https://www.mdpi.com/1420-3049/28/15/5780 |
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