Risk Factors of Cytomegalovirus Reactivation in Ulcerative Colitis Patients: A Meta-Analysis
Cytomegalovirus (CMV) infection is associated with exacerbation of disease activity in patients with ulcerative colitis (UC). However, the risk factors for CMV reactivation in this population remain debatable. This meta-analysis was performed to identify the risk factors for CMV reactivation in UC p...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/11/1952 |
| _version_ | 1797510635827757056 |
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| author | Yafei Qin Grace Wang Dejun Kong Guangming Li Hongda Wang Hong Qin Hao Wang |
| author_facet | Yafei Qin Grace Wang Dejun Kong Guangming Li Hongda Wang Hong Qin Hao Wang |
| author_sort | Yafei Qin |
| collection | DOAJ |
| description | Cytomegalovirus (CMV) infection is associated with exacerbation of disease activity in patients with ulcerative colitis (UC). However, the risk factors for CMV reactivation in this population remain debatable. This meta-analysis was performed to identify the risk factors for CMV reactivation in UC patients. PubMed, Cochrane Library, EMBASE, Web of Science, and China National Knowledge Infrastructure were searched from the inception of these databases to 31 August 2021, with the aim of identifying studies that investigated the risk factors of CMV reactivation in UC patients. A quality assessment of the included studies was performed with the Newcastle-Ottawa Scale. The publication bias was assessed respectively via a funnel plot and Egger’s regression asymmetry test. The robustness and reliability of each outcome were evaluated by sensitivity analysis. Twenty studies were included in the final meta-analysis, comprising a total of 2099 patients with UC. A significantly higher risk of CMV reactivation was observed in patients with severe UC (OR = 1.465, 95% CI: 1.107 to 1.939, <i>p</i> = 0.008), pancolitis (OR = 2.108, 95% CI: 1.586 to 2.800, <i>p</i> = 0.0001), older age of UC onset (MD = 6.212, 95% CI: 2.552 to 9.971, <i>p</i> = 0.001), as well as use of glucocorticoids (OR = 4.175, 95% CI: 3.076 to 5.666, <i>p</i> = 0.001), immunosuppressants (OR = 1.795, 95% CI: 1.289 to 2.501, <i>p</i> = 0.001), and azathioprine (OR = 1.444, 95% CI: 1.012 to 2.061, <i>p</i> = 0.043). However, infliximab treatment was observed not to increase the occurrence of CMV reactivation in patients who suffered from UC. In contrast, 5-aminosalicylic acid (OR = 0.674, 95% CI: 0.492 to 0.924, <i>p</i> = 0.014) was associated with a lower risk of CMV reactivation. Patients with UC should be closely monitored for risk factors of CMV reactivation in order to provide timely diagnosis and antiviral treatment. |
| first_indexed | 2024-03-10T05:34:08Z |
| format | Article |
| id | doaj.art-1e59d68dff354b08b8d323772a21d560 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T05:34:08Z |
| publishDate | 2021-10-01 |
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| series | Diagnostics |
| spelling | doaj.art-1e59d68dff354b08b8d323772a21d5602023-11-22T23:00:10ZengMDPI AGDiagnostics2075-44182021-10-011111195210.3390/diagnostics11111952Risk Factors of Cytomegalovirus Reactivation in Ulcerative Colitis Patients: A Meta-AnalysisYafei Qin0Grace Wang1Dejun Kong2Guangming Li3Hongda Wang4Hong Qin5Hao Wang6Department of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin 300052, ChinaFaculty of Medicine, University of Toronto, Toronto, ON M5S2E8, CanadaDepartment of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin 300052, ChinaDepartment of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin 300052, ChinaDepartment of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin 300052, ChinaDepartment of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin 300052, ChinaDepartment of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin 300052, ChinaCytomegalovirus (CMV) infection is associated with exacerbation of disease activity in patients with ulcerative colitis (UC). However, the risk factors for CMV reactivation in this population remain debatable. This meta-analysis was performed to identify the risk factors for CMV reactivation in UC patients. PubMed, Cochrane Library, EMBASE, Web of Science, and China National Knowledge Infrastructure were searched from the inception of these databases to 31 August 2021, with the aim of identifying studies that investigated the risk factors of CMV reactivation in UC patients. A quality assessment of the included studies was performed with the Newcastle-Ottawa Scale. The publication bias was assessed respectively via a funnel plot and Egger’s regression asymmetry test. The robustness and reliability of each outcome were evaluated by sensitivity analysis. Twenty studies were included in the final meta-analysis, comprising a total of 2099 patients with UC. A significantly higher risk of CMV reactivation was observed in patients with severe UC (OR = 1.465, 95% CI: 1.107 to 1.939, <i>p</i> = 0.008), pancolitis (OR = 2.108, 95% CI: 1.586 to 2.800, <i>p</i> = 0.0001), older age of UC onset (MD = 6.212, 95% CI: 2.552 to 9.971, <i>p</i> = 0.001), as well as use of glucocorticoids (OR = 4.175, 95% CI: 3.076 to 5.666, <i>p</i> = 0.001), immunosuppressants (OR = 1.795, 95% CI: 1.289 to 2.501, <i>p</i> = 0.001), and azathioprine (OR = 1.444, 95% CI: 1.012 to 2.061, <i>p</i> = 0.043). However, infliximab treatment was observed not to increase the occurrence of CMV reactivation in patients who suffered from UC. In contrast, 5-aminosalicylic acid (OR = 0.674, 95% CI: 0.492 to 0.924, <i>p</i> = 0.014) was associated with a lower risk of CMV reactivation. Patients with UC should be closely monitored for risk factors of CMV reactivation in order to provide timely diagnosis and antiviral treatment.https://www.mdpi.com/2075-4418/11/11/1952ulcerative colitiscytomegalovirusrisk factorsmeta-analysis |
| spellingShingle | Yafei Qin Grace Wang Dejun Kong Guangming Li Hongda Wang Hong Qin Hao Wang Risk Factors of Cytomegalovirus Reactivation in Ulcerative Colitis Patients: A Meta-Analysis Diagnostics ulcerative colitis cytomegalovirus risk factors meta-analysis |
| title | Risk Factors of Cytomegalovirus Reactivation in Ulcerative Colitis Patients: A Meta-Analysis |
| title_full | Risk Factors of Cytomegalovirus Reactivation in Ulcerative Colitis Patients: A Meta-Analysis |
| title_fullStr | Risk Factors of Cytomegalovirus Reactivation in Ulcerative Colitis Patients: A Meta-Analysis |
| title_full_unstemmed | Risk Factors of Cytomegalovirus Reactivation in Ulcerative Colitis Patients: A Meta-Analysis |
| title_short | Risk Factors of Cytomegalovirus Reactivation in Ulcerative Colitis Patients: A Meta-Analysis |
| title_sort | risk factors of cytomegalovirus reactivation in ulcerative colitis patients a meta analysis |
| topic | ulcerative colitis cytomegalovirus risk factors meta-analysis |
| url | https://www.mdpi.com/2075-4418/11/11/1952 |
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