Protective effects of Lactobacillus reuteri SJ-47 strain exopolysaccharides on human skin fibroblasts damaged by UVA radiation
Abstract Ultraviolet rays in sunlight can cause skin damage and premature aging. This study demonstrates that Lactobacillus reuteri SJ-47 strain exopolysaccharides (EPS) protect human skin fibroblasts (HSF) under UVA radiation. During the course of the experiments, we investigate the oxidative stres...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-12-01
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| Series: | Bioresources and Bioprocessing |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40643-022-00617-0 |
| _version_ | 1811199498860363776 |
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| author | Jingsha Zhao Hao Fu Yongtao Zhang Meng Li Dongdong Wang Dan Zhao Jiachan Zhang Changtao Wang |
| author_facet | Jingsha Zhao Hao Fu Yongtao Zhang Meng Li Dongdong Wang Dan Zhao Jiachan Zhang Changtao Wang |
| author_sort | Jingsha Zhao |
| collection | DOAJ |
| description | Abstract Ultraviolet rays in sunlight can cause skin damage and premature aging. This study demonstrates that Lactobacillus reuteri SJ-47 strain exopolysaccharides (EPS) protect human skin fibroblasts (HSF) under UVA radiation. During the course of the experiments, we investigate the oxidative stress protection and antiaging effects of exopolysaccharides on HSF at the biochemical, cellular, and molecular levels. The results show that EPS can increase the antioxidant capacity of cells, decrease the amount of reactive-oxygen species (ROS) and malondialdehyde (MDA), while improve the expression of antioxidant enzymes. At the same time, EPS can increase collagen content, which can effectively regulate the expression of genes in the senescence and apoptosis pathways, and delay skin photoaging caused by UVA irradiation. Graphical Abstract |
| first_indexed | 2024-04-12T01:50:10Z |
| format | Article |
| id | doaj.art-1e5e0ff887164151b006ef782f1186d9 |
| institution | Directory Open Access Journal |
| issn | 2197-4365 |
| language | English |
| last_indexed | 2024-04-12T01:50:10Z |
| publishDate | 2022-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Bioresources and Bioprocessing |
| spelling | doaj.art-1e5e0ff887164151b006ef782f1186d92022-12-22T03:52:58ZengSpringerOpenBioresources and Bioprocessing2197-43652022-12-019111210.1186/s40643-022-00617-0Protective effects of Lactobacillus reuteri SJ-47 strain exopolysaccharides on human skin fibroblasts damaged by UVA radiationJingsha Zhao0Hao Fu1Yongtao Zhang2Meng Li3Dongdong Wang4Dan Zhao5Jiachan Zhang6Changtao Wang7Beijing Key Laboratory of Plant Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business UniversityBeijing Key Laboratory of Plant Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business UniversityBeijing Key Laboratory of Plant Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business UniversityBeijing Key Laboratory of Plant Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business UniversityBeijing Key Laboratory of Plant Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business UniversityBeijing Key Laboratory of Plant Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business UniversityBeijing Key Laboratory of Plant Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business UniversityBeijing Key Laboratory of Plant Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business UniversityAbstract Ultraviolet rays in sunlight can cause skin damage and premature aging. This study demonstrates that Lactobacillus reuteri SJ-47 strain exopolysaccharides (EPS) protect human skin fibroblasts (HSF) under UVA radiation. During the course of the experiments, we investigate the oxidative stress protection and antiaging effects of exopolysaccharides on HSF at the biochemical, cellular, and molecular levels. The results show that EPS can increase the antioxidant capacity of cells, decrease the amount of reactive-oxygen species (ROS) and malondialdehyde (MDA), while improve the expression of antioxidant enzymes. At the same time, EPS can increase collagen content, which can effectively regulate the expression of genes in the senescence and apoptosis pathways, and delay skin photoaging caused by UVA irradiation. Graphical Abstracthttps://doi.org/10.1186/s40643-022-00617-0Lactobacillus reuteri SJ-47 strain exopolysaccharidesSkin photoagingOxidative stress |
| spellingShingle | Jingsha Zhao Hao Fu Yongtao Zhang Meng Li Dongdong Wang Dan Zhao Jiachan Zhang Changtao Wang Protective effects of Lactobacillus reuteri SJ-47 strain exopolysaccharides on human skin fibroblasts damaged by UVA radiation Bioresources and Bioprocessing Lactobacillus reuteri SJ-47 strain exopolysaccharides Skin photoaging Oxidative stress |
| title | Protective effects of Lactobacillus reuteri SJ-47 strain exopolysaccharides on human skin fibroblasts damaged by UVA radiation |
| title_full | Protective effects of Lactobacillus reuteri SJ-47 strain exopolysaccharides on human skin fibroblasts damaged by UVA radiation |
| title_fullStr | Protective effects of Lactobacillus reuteri SJ-47 strain exopolysaccharides on human skin fibroblasts damaged by UVA radiation |
| title_full_unstemmed | Protective effects of Lactobacillus reuteri SJ-47 strain exopolysaccharides on human skin fibroblasts damaged by UVA radiation |
| title_short | Protective effects of Lactobacillus reuteri SJ-47 strain exopolysaccharides on human skin fibroblasts damaged by UVA radiation |
| title_sort | protective effects of lactobacillus reuteri sj 47 strain exopolysaccharides on human skin fibroblasts damaged by uva radiation |
| topic | Lactobacillus reuteri SJ-47 strain exopolysaccharides Skin photoaging Oxidative stress |
| url | https://doi.org/10.1186/s40643-022-00617-0 |
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