Response of high-sensitive C-reactive protein to catheter ablation of atrial fibrillation and its relation with rhythm outcome.
AIMS: This study investigated the possible association between hs-CRP as well as hs-CRP changes and rhythm outcome after AF catheter ablation. METHODS: We studied 68 consecutive patients with AF undergoing catheter ablation. hs-CRP levels were measured using commercially available assays before and...
| Auteurs principaux: | , , , , , , , |
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| Format: | Article |
| Langue: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Collection: | PLoS ONE |
| Accès en ligne: | http://europepmc.org/articles/PMC3431323?pdf=render |
| _version_ | 1828388252267053056 |
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| author | Jelena Kornej Claudia Reinhardt Jedrzej Kosiuk Arash Arya Gerhard Hindricks Volker Adams Daniela Husser Andreas Bollmann |
| author_facet | Jelena Kornej Claudia Reinhardt Jedrzej Kosiuk Arash Arya Gerhard Hindricks Volker Adams Daniela Husser Andreas Bollmann |
| author_sort | Jelena Kornej |
| collection | DOAJ |
| description | AIMS: This study investigated the possible association between hs-CRP as well as hs-CRP changes and rhythm outcome after AF catheter ablation. METHODS: We studied 68 consecutive patients with AF undergoing catheter ablation. hs-CRP levels were measured using commercially available assays before and 6 months after catheter ablation. Serial 7-day Holter ECGs were used to detect AF recurrences. RESULTS: Early AF recurrence (ERAF, within one week) was observed in 38%, while late AF recurrence (LRAF, between 3 and 6 months) occurred in 18% of the patients. None of the baseline clinical or echocardiographic variables was predictive of ERAF or LRAF. Baseline hs-CRP measured 2.07 ± 1.1 µg/ml and was not associated with ERAF and LRAF. At 6 months, hs-CRP levels were comparable with baseline values (2.14±1.19 µg/ml, p = 0.409) and were also not related with LRAF. However, patients with LRAF showed an hs-CRP increase from 2.03 ± 0.61 to 2.62 ± 1.52 µg/ml (p = 0.028). Patients with an hs-CRP change in the upper tertile (>0.2 µg/ml) had LRAF in 32% as opposed to 11% (p = 0.042) in patients in the lower (<-0.3 µg/ml) or intermediate (-0.3-0.2 µg/ml) tertile. CONCLUSIONS: Changes in hs-CRP but not baseline hs-CRP are associated with rhythm outcome after AF catheter ablation. This finding points to a link between an inflammatory response and AF recurrence in this setting. |
| first_indexed | 2024-12-10T06:08:28Z |
| format | Article |
| id | doaj.art-1e5e43c88d7d4dba93d714803f2f610b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T06:08:28Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1e5e43c88d7d4dba93d714803f2f610b2022-12-22T01:59:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0178e4416510.1371/journal.pone.0044165Response of high-sensitive C-reactive protein to catheter ablation of atrial fibrillation and its relation with rhythm outcome.Jelena KornejClaudia ReinhardtJedrzej KosiukArash AryaGerhard HindricksVolker AdamsDaniela HusserAndreas BollmannAIMS: This study investigated the possible association between hs-CRP as well as hs-CRP changes and rhythm outcome after AF catheter ablation. METHODS: We studied 68 consecutive patients with AF undergoing catheter ablation. hs-CRP levels were measured using commercially available assays before and 6 months after catheter ablation. Serial 7-day Holter ECGs were used to detect AF recurrences. RESULTS: Early AF recurrence (ERAF, within one week) was observed in 38%, while late AF recurrence (LRAF, between 3 and 6 months) occurred in 18% of the patients. None of the baseline clinical or echocardiographic variables was predictive of ERAF or LRAF. Baseline hs-CRP measured 2.07 ± 1.1 µg/ml and was not associated with ERAF and LRAF. At 6 months, hs-CRP levels were comparable with baseline values (2.14±1.19 µg/ml, p = 0.409) and were also not related with LRAF. However, patients with LRAF showed an hs-CRP increase from 2.03 ± 0.61 to 2.62 ± 1.52 µg/ml (p = 0.028). Patients with an hs-CRP change in the upper tertile (>0.2 µg/ml) had LRAF in 32% as opposed to 11% (p = 0.042) in patients in the lower (<-0.3 µg/ml) or intermediate (-0.3-0.2 µg/ml) tertile. CONCLUSIONS: Changes in hs-CRP but not baseline hs-CRP are associated with rhythm outcome after AF catheter ablation. This finding points to a link between an inflammatory response and AF recurrence in this setting.http://europepmc.org/articles/PMC3431323?pdf=render |
| spellingShingle | Jelena Kornej Claudia Reinhardt Jedrzej Kosiuk Arash Arya Gerhard Hindricks Volker Adams Daniela Husser Andreas Bollmann Response of high-sensitive C-reactive protein to catheter ablation of atrial fibrillation and its relation with rhythm outcome. PLoS ONE |
| title | Response of high-sensitive C-reactive protein to catheter ablation of atrial fibrillation and its relation with rhythm outcome. |
| title_full | Response of high-sensitive C-reactive protein to catheter ablation of atrial fibrillation and its relation with rhythm outcome. |
| title_fullStr | Response of high-sensitive C-reactive protein to catheter ablation of atrial fibrillation and its relation with rhythm outcome. |
| title_full_unstemmed | Response of high-sensitive C-reactive protein to catheter ablation of atrial fibrillation and its relation with rhythm outcome. |
| title_short | Response of high-sensitive C-reactive protein to catheter ablation of atrial fibrillation and its relation with rhythm outcome. |
| title_sort | response of high sensitive c reactive protein to catheter ablation of atrial fibrillation and its relation with rhythm outcome |
| url | http://europepmc.org/articles/PMC3431323?pdf=render |
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