Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model

Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model

Abstract Background Alzheimer’s disease (AD) patients exhibit memory disruptions and profound sleep disturbances, including disruption of deep non-rapid eye movement (NREM) sleep. Slow-wave activity (SWA) is a major restorative feature of NREM sleep and is important for memory consolidation. Methods...

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Bibliographic Details
Main Authors: Qiuchen Zhao, Megi Maci, Morgan R. Miller, Heng Zhou, Fang Zhang, Moustafa Algamal, Yee Fun Lee, Steven S. Hou, Stephen J. Perle, Hoang Le, Alyssa N. Russ, Eng H. Lo, Dmitry Gerashchenko, Stephen N. Gomperts, Brian J. Bacskai, Ksenia V. Kastanenka
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Molecular Neurodegeneration
Subjects:
Optogenetics
Microglia
EEG
Sleep
Slow oscillations
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s13024-023-00682-9

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