Dietary Supplementation of Ancientino Ameliorates Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Reducing Inflammation and Oxidative Stress
Ancientino, a complex dietary fiber supplement mimicking the ancient diet, has improved chronic heart failure, kidney function, and constipation. However, its effect on ulcerative colitis is unknown. This study explores the impact of Ancientino on colitis caused by dextran sulfate sodium (DSS) and i...
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MDPI AG
2023-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/12/2798 |
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| author | Meng Liu Yuhui Wang Guoqiang Guan Xi Lu Yizhun Zhu Xiaoqun Duan |
| author_facet | Meng Liu Yuhui Wang Guoqiang Guan Xi Lu Yizhun Zhu Xiaoqun Duan |
| author_sort | Meng Liu |
| collection | DOAJ |
| description | Ancientino, a complex dietary fiber supplement mimicking the ancient diet, has improved chronic heart failure, kidney function, and constipation. However, its effect on ulcerative colitis is unknown. This study explores the impact of Ancientino on colitis caused by dextran sulfate sodium (DSS) and its mechanisms. Data analyses showed that Ancientino alleviated bodyweight loss, colon shortening and injury, and disease activity index (DAI) score, regulated levels of inflammatory factors (tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), interleukin-1 beta (IL-1β), and interleukin 6 (IL-6)), reduced intestinal permeability (<span style="font-variant: small-caps;">d</span>-lactate and endotoxin), fluorescein isothiocyanate–dextran (FITC-dextran), and diamine oxidase (DAO), repaired colonic function (ZO-1 and occludin), and suppressed oxidative stress (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA)) in vivo and in vitro. In short, this study demonstrated that Ancientino alleviates colitis and exerts an anticolitis effect by reducing inflammatory response, suppressing oxidative stress, and repairing intestinal barrier function. Thus, Ancientino may be an effective therapeutic dietary resource for ulcerative colitis. |
| first_indexed | 2024-03-11T02:03:55Z |
| format | Article |
| id | doaj.art-1e5ff4cd134d4fed8ad24abd3cbf37ca |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T02:03:55Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-1e5ff4cd134d4fed8ad24abd3cbf37ca2023-11-18T11:57:44ZengMDPI AGNutrients2072-66432023-06-011512279810.3390/nu15122798Dietary Supplementation of Ancientino Ameliorates Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Reducing Inflammation and Oxidative StressMeng Liu0Yuhui Wang1Guoqiang Guan2Xi Lu3Yizhun Zhu4Xiaoqun Duan5School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau SAR 999078, ChinaSchool of Biomedical Industry, Guilin Medical University, Guilin 541199, ChinaSchool of Biomedical Industry, Guilin Medical University, Guilin 541199, ChinaSchool of Pharmacy, Guilin Medical University, Guilin 541199, ChinaSchool of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau SAR 999078, ChinaSchool of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau SAR 999078, ChinaAncientino, a complex dietary fiber supplement mimicking the ancient diet, has improved chronic heart failure, kidney function, and constipation. However, its effect on ulcerative colitis is unknown. This study explores the impact of Ancientino on colitis caused by dextran sulfate sodium (DSS) and its mechanisms. Data analyses showed that Ancientino alleviated bodyweight loss, colon shortening and injury, and disease activity index (DAI) score, regulated levels of inflammatory factors (tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), interleukin-1 beta (IL-1β), and interleukin 6 (IL-6)), reduced intestinal permeability (<span style="font-variant: small-caps;">d</span>-lactate and endotoxin), fluorescein isothiocyanate–dextran (FITC-dextran), and diamine oxidase (DAO), repaired colonic function (ZO-1 and occludin), and suppressed oxidative stress (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA)) in vivo and in vitro. In short, this study demonstrated that Ancientino alleviates colitis and exerts an anticolitis effect by reducing inflammatory response, suppressing oxidative stress, and repairing intestinal barrier function. Thus, Ancientino may be an effective therapeutic dietary resource for ulcerative colitis.https://www.mdpi.com/2072-6643/15/12/2798ulcerative colitisAncientinoinflammatory responseintestinal barrier functionoxidation stress |
| spellingShingle | Meng Liu Yuhui Wang Guoqiang Guan Xi Lu Yizhun Zhu Xiaoqun Duan Dietary Supplementation of Ancientino Ameliorates Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Reducing Inflammation and Oxidative Stress Nutrients ulcerative colitis Ancientino inflammatory response intestinal barrier function oxidation stress |
| title | Dietary Supplementation of Ancientino Ameliorates Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Reducing Inflammation and Oxidative Stress |
| title_full | Dietary Supplementation of Ancientino Ameliorates Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Reducing Inflammation and Oxidative Stress |
| title_fullStr | Dietary Supplementation of Ancientino Ameliorates Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Reducing Inflammation and Oxidative Stress |
| title_full_unstemmed | Dietary Supplementation of Ancientino Ameliorates Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Reducing Inflammation and Oxidative Stress |
| title_short | Dietary Supplementation of Ancientino Ameliorates Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Reducing Inflammation and Oxidative Stress |
| title_sort | dietary supplementation of ancientino ameliorates dextran sodium sulfate induced colitis by improving intestinal barrier function and reducing inflammation and oxidative stress |
| topic | ulcerative colitis Ancientino inflammatory response intestinal barrier function oxidation stress |
| url | https://www.mdpi.com/2072-6643/15/12/2798 |
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