<i>Trichuris muris</i> Model: Role in Understanding Intestinal Immune Response, Inflammation and Host Defense
Several parasites have evolved to survive in the human intestinal tract and over 1 billion people around the world, specifically in developing countries, are infected with enteric helminths. <i>Trichuris trichiura</i> is one of the world’s most common intestinal parasites that causes hum...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/8/925 |
| _version_ | 1797522477817004032 |
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| author | Yeganeh Yousefi Sabah Haq Suhrid Banskota Yun Han Kwon Waliul I. Khan |
| author_facet | Yeganeh Yousefi Sabah Haq Suhrid Banskota Yun Han Kwon Waliul I. Khan |
| author_sort | Yeganeh Yousefi |
| collection | DOAJ |
| description | Several parasites have evolved to survive in the human intestinal tract and over 1 billion people around the world, specifically in developing countries, are infected with enteric helminths. <i>Trichuris trichiura</i> is one of the world’s most common intestinal parasites that causes human parasitic infections. <i>Trichuris muris</i>, as an immunologically well-defined mouse model of <i>T. trichiura</i>, is extensively used to study different aspects of the innate and adaptive components of the immune system. Studies on <i>T. muris</i> model offer insights into understanding host immunity, since this parasite generates two distinct immune responses in resistant and susceptible strains of mouse. Apart from the immune cells, <i>T. muris</i> infection also influences various components of the intestinal tract, especially the gut microbiota, mucus layer, epithelial cells and smooth muscle cells. Here, we reviewed the different immune responses generated by innate and adaptive immune components during acute and chronic <i>T. muris</i> infections. Furthermore, we discussed the importance of studying <i>T. muris</i> model in understanding host–parasite interaction in the context of alteration in the host’s microbiota, intestinal barrier, inflammation, and host defense, and in parasite infection-mediated modulation of other immune and inflammatory diseases. |
| first_indexed | 2024-03-10T08:29:57Z |
| format | Article |
| id | doaj.art-1e617bc761564cc89ed8d1bd1f2a9898 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T08:29:57Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-1e617bc761564cc89ed8d1bd1f2a98982023-11-22T09:08:04ZengMDPI AGPathogens2076-08172021-07-0110892510.3390/pathogens10080925<i>Trichuris muris</i> Model: Role in Understanding Intestinal Immune Response, Inflammation and Host DefenseYeganeh Yousefi0Sabah Haq1Suhrid Banskota2Yun Han Kwon3Waliul I. Khan4Farncombe Family Digestive Health Research Institute, McMaster University Health Sciences Centre Room 3N7, 1280 Main St. W, Hamilton, ON L8N 3Z5, CanadaFarncombe Family Digestive Health Research Institute, McMaster University Health Sciences Centre Room 3N7, 1280 Main St. W, Hamilton, ON L8N 3Z5, CanadaFarncombe Family Digestive Health Research Institute, McMaster University Health Sciences Centre Room 3N7, 1280 Main St. W, Hamilton, ON L8N 3Z5, CanadaFarncombe Family Digestive Health Research Institute, McMaster University Health Sciences Centre Room 3N7, 1280 Main St. W, Hamilton, ON L8N 3Z5, CanadaFarncombe Family Digestive Health Research Institute, McMaster University Health Sciences Centre Room 3N7, 1280 Main St. W, Hamilton, ON L8N 3Z5, CanadaSeveral parasites have evolved to survive in the human intestinal tract and over 1 billion people around the world, specifically in developing countries, are infected with enteric helminths. <i>Trichuris trichiura</i> is one of the world’s most common intestinal parasites that causes human parasitic infections. <i>Trichuris muris</i>, as an immunologically well-defined mouse model of <i>T. trichiura</i>, is extensively used to study different aspects of the innate and adaptive components of the immune system. Studies on <i>T. muris</i> model offer insights into understanding host immunity, since this parasite generates two distinct immune responses in resistant and susceptible strains of mouse. Apart from the immune cells, <i>T. muris</i> infection also influences various components of the intestinal tract, especially the gut microbiota, mucus layer, epithelial cells and smooth muscle cells. Here, we reviewed the different immune responses generated by innate and adaptive immune components during acute and chronic <i>T. muris</i> infections. Furthermore, we discussed the importance of studying <i>T. muris</i> model in understanding host–parasite interaction in the context of alteration in the host’s microbiota, intestinal barrier, inflammation, and host defense, and in parasite infection-mediated modulation of other immune and inflammatory diseases.https://www.mdpi.com/2076-0817/10/8/925intestinal helminth<i>Trichuris muris</i>immune responsehost–parasite interactionhost defenseepithelial cells |
| spellingShingle | Yeganeh Yousefi Sabah Haq Suhrid Banskota Yun Han Kwon Waliul I. Khan <i>Trichuris muris</i> Model: Role in Understanding Intestinal Immune Response, Inflammation and Host Defense Pathogens intestinal helminth <i>Trichuris muris</i> immune response host–parasite interaction host defense epithelial cells |
| title | <i>Trichuris muris</i> Model: Role in Understanding Intestinal Immune Response, Inflammation and Host Defense |
| title_full | <i>Trichuris muris</i> Model: Role in Understanding Intestinal Immune Response, Inflammation and Host Defense |
| title_fullStr | <i>Trichuris muris</i> Model: Role in Understanding Intestinal Immune Response, Inflammation and Host Defense |
| title_full_unstemmed | <i>Trichuris muris</i> Model: Role in Understanding Intestinal Immune Response, Inflammation and Host Defense |
| title_short | <i>Trichuris muris</i> Model: Role in Understanding Intestinal Immune Response, Inflammation and Host Defense |
| title_sort | i trichuris muris i model role in understanding intestinal immune response inflammation and host defense |
| topic | intestinal helminth <i>Trichuris muris</i> immune response host–parasite interaction host defense epithelial cells |
| url | https://www.mdpi.com/2076-0817/10/8/925 |
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