Integrated Resonant Micro/Nano Gravimetric Sensors for Bio/Chemical Detection in Air and Liquid

Resonant micro/nanoelectromechanical systems (MEMS/NEMS) with on-chip integrated excitation and readout components, exhibit exquisite gravimetric sensitivities which have greatly advanced the bio/chemical sensor technologies in the past two decades. This paper reviews the development of integrated M...

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Main Authors: Hao Jia, Pengcheng Xu, Xinxin Li
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Micromachines
Subjects:
Online Access:https://www.mdpi.com/2072-666X/12/6/645
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author Hao Jia
Pengcheng Xu
Xinxin Li
author_facet Hao Jia
Pengcheng Xu
Xinxin Li
author_sort Hao Jia
collection DOAJ
description Resonant micro/nanoelectromechanical systems (MEMS/NEMS) with on-chip integrated excitation and readout components, exhibit exquisite gravimetric sensitivities which have greatly advanced the bio/chemical sensor technologies in the past two decades. This paper reviews the development of integrated MEMS/NEMS resonators for bio/chemical sensing applications mainly in air and liquid. Different vibrational modes (bending, torsional, in-plane, and extensional modes) have been exploited to enhance the quality (<i>Q</i>) factors and mass sensing performance in viscous media. Such resonant mass sensors have shown great potential in detecting many kinds of trace analytes in gas and liquid phases, such as chemical vapors, volatile organic compounds, pollutant gases, bacteria, biomarkers, and DNA. The integrated MEMS/NEMS mass sensors will continuously push the detection limit of trace bio/chemical molecules and bring a better understanding of gas/nanomaterial interaction and molecular binding mechanisms.
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spelling doaj.art-1e6291db15f74bf6b5acfdff4a3e913b2023-11-21T22:18:46ZengMDPI AGMicromachines2072-666X2021-05-0112664510.3390/mi12060645Integrated Resonant Micro/Nano Gravimetric Sensors for Bio/Chemical Detection in Air and LiquidHao Jia0Pengcheng Xu1Xinxin Li2State Key Lab of Transducer Technology, Shanghai Institute of Microsystem & Information Technology, Chinese Academy of Sciences, 865 Changning Road, Shanghai 200050, ChinaState Key Lab of Transducer Technology, Shanghai Institute of Microsystem & Information Technology, Chinese Academy of Sciences, 865 Changning Road, Shanghai 200050, ChinaState Key Lab of Transducer Technology, Shanghai Institute of Microsystem & Information Technology, Chinese Academy of Sciences, 865 Changning Road, Shanghai 200050, ChinaResonant micro/nanoelectromechanical systems (MEMS/NEMS) with on-chip integrated excitation and readout components, exhibit exquisite gravimetric sensitivities which have greatly advanced the bio/chemical sensor technologies in the past two decades. This paper reviews the development of integrated MEMS/NEMS resonators for bio/chemical sensing applications mainly in air and liquid. Different vibrational modes (bending, torsional, in-plane, and extensional modes) have been exploited to enhance the quality (<i>Q</i>) factors and mass sensing performance in viscous media. Such resonant mass sensors have shown great potential in detecting many kinds of trace analytes in gas and liquid phases, such as chemical vapors, volatile organic compounds, pollutant gases, bacteria, biomarkers, and DNA. The integrated MEMS/NEMS mass sensors will continuously push the detection limit of trace bio/chemical molecules and bring a better understanding of gas/nanomaterial interaction and molecular binding mechanisms.https://www.mdpi.com/2072-666X/12/6/645integrated resonatorsgravimetric sensorsbio/chemical sensingquality factorresonant modes
spellingShingle Hao Jia
Pengcheng Xu
Xinxin Li
Integrated Resonant Micro/Nano Gravimetric Sensors for Bio/Chemical Detection in Air and Liquid
Micromachines
integrated resonators
gravimetric sensors
bio/chemical sensing
quality factor
resonant modes
title Integrated Resonant Micro/Nano Gravimetric Sensors for Bio/Chemical Detection in Air and Liquid
title_full Integrated Resonant Micro/Nano Gravimetric Sensors for Bio/Chemical Detection in Air and Liquid
title_fullStr Integrated Resonant Micro/Nano Gravimetric Sensors for Bio/Chemical Detection in Air and Liquid
title_full_unstemmed Integrated Resonant Micro/Nano Gravimetric Sensors for Bio/Chemical Detection in Air and Liquid
title_short Integrated Resonant Micro/Nano Gravimetric Sensors for Bio/Chemical Detection in Air and Liquid
title_sort integrated resonant micro nano gravimetric sensors for bio chemical detection in air and liquid
topic integrated resonators
gravimetric sensors
bio/chemical sensing
quality factor
resonant modes
url https://www.mdpi.com/2072-666X/12/6/645
work_keys_str_mv AT haojia integratedresonantmicronanogravimetricsensorsforbiochemicaldetectioninairandliquid
AT pengchengxu integratedresonantmicronanogravimetricsensorsforbiochemicaldetectioninairandliquid
AT xinxinli integratedresonantmicronanogravimetricsensorsforbiochemicaldetectioninairandliquid