Impact of multivalent charge presentation on peptide–nanoparticle aggregation
Strategies to achieve controlled nanoparticle aggregation have gained much interest, due to the versatility of such systems and their applications in materials science and medicine. In this article we demonstrate that coiled-coil peptide-induced aggregation based on electrostatic interactions is hig...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2015-05-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.11.89 |
| _version_ | 1818398634664787968 |
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| author | Daniel Schöne Boris Schade Christoph Böttcher Beate Koksch |
| author_facet | Daniel Schöne Boris Schade Christoph Böttcher Beate Koksch |
| author_sort | Daniel Schöne |
| collection | DOAJ |
| description | Strategies to achieve controlled nanoparticle aggregation have gained much interest, due to the versatility of such systems and their applications in materials science and medicine. In this article we demonstrate that coiled-coil peptide-induced aggregation based on electrostatic interactions is highly sensitive to the length of the peptide as well as the number of presented charges. The quaternary structure of the peptide was found to play an important role in aggregation kinetics. Furthermore, we show that the presence of peptide fibers leads to well-defined nanoparticle assembly on the surface of these macrostructures. |
| first_indexed | 2024-12-14T07:07:54Z |
| format | Article |
| id | doaj.art-1e62c7465625418bab3d02be4ab7cb97 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-14T07:07:54Z |
| publishDate | 2015-05-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-1e62c7465625418bab3d02be4ab7cb972022-12-21T23:12:04ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972015-05-0111179280310.3762/bjoc.11.891860-5397-11-89Impact of multivalent charge presentation on peptide–nanoparticle aggregationDaniel Schöne0Boris Schade1Christoph Böttcher2Beate Koksch3Institute of Chemistry and Biochemistry - Organic Chemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, GermanyElectron Microscopy, Freie Universität Berlin, Fabeckstr. 36a, 14195 Berlin, GermanyElectron Microscopy, Freie Universität Berlin, Fabeckstr. 36a, 14195 Berlin, GermanyInstitute of Chemistry and Biochemistry - Organic Chemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, GermanyStrategies to achieve controlled nanoparticle aggregation have gained much interest, due to the versatility of such systems and their applications in materials science and medicine. In this article we demonstrate that coiled-coil peptide-induced aggregation based on electrostatic interactions is highly sensitive to the length of the peptide as well as the number of presented charges. The quaternary structure of the peptide was found to play an important role in aggregation kinetics. Furthermore, we show that the presence of peptide fibers leads to well-defined nanoparticle assembly on the surface of these macrostructures.https://doi.org/10.3762/bjoc.11.89coiled-coil peptidesα-helical fibrilscontrolled aggregationgold nanoparticlesmultivalency |
| spellingShingle | Daniel Schöne Boris Schade Christoph Böttcher Beate Koksch Impact of multivalent charge presentation on peptide–nanoparticle aggregation Beilstein Journal of Organic Chemistry coiled-coil peptides α-helical fibrils controlled aggregation gold nanoparticles multivalency |
| title | Impact of multivalent charge presentation on peptide–nanoparticle aggregation |
| title_full | Impact of multivalent charge presentation on peptide–nanoparticle aggregation |
| title_fullStr | Impact of multivalent charge presentation on peptide–nanoparticle aggregation |
| title_full_unstemmed | Impact of multivalent charge presentation on peptide–nanoparticle aggregation |
| title_short | Impact of multivalent charge presentation on peptide–nanoparticle aggregation |
| title_sort | impact of multivalent charge presentation on peptide nanoparticle aggregation |
| topic | coiled-coil peptides α-helical fibrils controlled aggregation gold nanoparticles multivalency |
| url | https://doi.org/10.3762/bjoc.11.89 |
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