Hypolipidemic agent Z-guggulsterone: metabolism interplays with induction of carboxylesterase and bile salt export pump

Hypolipidemic agent Z-guggulsterone: metabolism interplays with induction of carboxylesterase and bile salt export pump

Z-Guggulsterone is a major ingredient in the Indian traditional hypolipidemic remedy guggul. A study in mice has established that its hypolipidemic effect involves the farnesoid X receptor (FXR), presumably by acting as an antagonist of this receptor. It is generally assumed that the antagonism lead...

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Bibliographic Details
Main Authors:	Dongfang Yang, Jian Yang, Deshi Shi, Da Xiao, Yi-Tzai Chen, Chris Black, Ruitang Deng, Bingfang Yan
Format:	Article
Language:	English
Published:	Elsevier 2012-03-01
Series:	Journal of Lipid Research
Subjects:	atherlosclerosis bile acids dyslipidemias carboxylesterase cytochrome P450 7A1 transactivation
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520413689

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