The effect of blood flow restriction exercise on N-lactoylphenylalanine and appetite regulation in obese adults: a cross-design study
BackgroundN-lactoylphenylalanine (Lac-Phe) is a new form of “exerkines” closely related to lactate (La), which may be able to inhibit appetite. Blood flow restriction (BFR) can lead to local tissue hypoxia and increase lactate accumulation. Therefore, this study investigated the effects of combining...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1289574/full |
| _version_ | 1797404492507906048 |
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| author | Shuoqi Li Rong Guo Juncheng Wang Xinyu Zheng Shuo Zhao Zhiru Zhang Wenbing Yu Shiming Li Peng Zheng |
| author_facet | Shuoqi Li Rong Guo Juncheng Wang Xinyu Zheng Shuo Zhao Zhiru Zhang Wenbing Yu Shiming Li Peng Zheng |
| author_sort | Shuoqi Li |
| collection | DOAJ |
| description | BackgroundN-lactoylphenylalanine (Lac-Phe) is a new form of “exerkines” closely related to lactate (La), which may be able to inhibit appetite. Blood flow restriction (BFR) can lead to local tissue hypoxia and increase lactate accumulation. Therefore, this study investigated the effects of combining Moderate-intensity Continuous Exercise (MICE) with BFR on Lac-Phe and appetite regulation in obese adults.MethodsThis study employed the cross-design study and recruited 14 obese adults aged 18-24 years. The participants were randomly divided into three groups and performed several tests with specific experimental conditions: (1) M group (MICE without BFR, 60%VO2max, 200 kJ); (2) B group (MICE with BFR, 60%VO2max, 200 kJ); and (3) C group (control session without exercise). Participants were given a standardized meal 60 min before exercise and a ad libitum 60 min after exercise. In addition, blood and Visual Analogue Scale (VAS) were collected before, immediately after, and 1 hour after performing the exercise.ResultsNo significant difference in each index was detected before exercise. After exercise, the primary differential metabolites detected in the M and B groups were xanthine, La, succinate, Lac-Phe, citrate, urocanic acid, and myristic acid. Apart from that, the major enrichment pathways include the citrate cycle, alanine, aspartate, and glutamate metabolism. The enhanced Lac-Phe and La level in the B group was higher than M and C groups. Hunger of the B group immediately after exercise substantially differed from M group. The total ghrelin, glucagon-like peptide-1 and hunger in the B group 1 hour after exercise differed substantially from M group. The results of calorie intake showed no significant difference among the indexes in each group.ConclusionsIn conclusion, this cross-design study demonstrated that the combined MICE and BFR exercise reduced the appetite of obese adults by promoting the secretion of Lac-Phe and ghrelin. However, the exercise did not considerably affect the subsequent ad libitum intake. |
| first_indexed | 2024-03-09T02:55:46Z |
| format | Article |
| id | doaj.art-1e661e400a7b4f0b82a8cbd9992af723 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-09T02:55:46Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-1e661e400a7b4f0b82a8cbd9992af7232023-12-05T05:13:53ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-12-011410.3389/fendo.2023.12895741289574The effect of blood flow restriction exercise on N-lactoylphenylalanine and appetite regulation in obese adults: a cross-design studyShuoqi Li0Rong Guo1Juncheng Wang2Xinyu Zheng3Shuo Zhao4Zhiru Zhang5Wenbing Yu6Shiming Li7Peng Zheng8School of Sports Science, Nantong University, Nantong, ChinaSchool of Foreign Languages, Ludong University, Yantai, ChinaDepartment of Physical Education, Ocean University of China, Qingdao, ChinaDepartment of Physical Education, Ocean University of China, Qingdao, ChinaDepartment of Physical Education, Ocean University of China, Qingdao, ChinaDepartment of Physical Education, Ocean University of China, Qingdao, ChinaDepartment of Physical Education, Ocean University of China, Qingdao, ChinaDepartment of Physical Education, Ocean University of China, Qingdao, ChinaDepartment of Physical Education, Ocean University of China, Qingdao, ChinaBackgroundN-lactoylphenylalanine (Lac-Phe) is a new form of “exerkines” closely related to lactate (La), which may be able to inhibit appetite. Blood flow restriction (BFR) can lead to local tissue hypoxia and increase lactate accumulation. Therefore, this study investigated the effects of combining Moderate-intensity Continuous Exercise (MICE) with BFR on Lac-Phe and appetite regulation in obese adults.MethodsThis study employed the cross-design study and recruited 14 obese adults aged 18-24 years. The participants were randomly divided into three groups and performed several tests with specific experimental conditions: (1) M group (MICE without BFR, 60%VO2max, 200 kJ); (2) B group (MICE with BFR, 60%VO2max, 200 kJ); and (3) C group (control session without exercise). Participants were given a standardized meal 60 min before exercise and a ad libitum 60 min after exercise. In addition, blood and Visual Analogue Scale (VAS) were collected before, immediately after, and 1 hour after performing the exercise.ResultsNo significant difference in each index was detected before exercise. After exercise, the primary differential metabolites detected in the M and B groups were xanthine, La, succinate, Lac-Phe, citrate, urocanic acid, and myristic acid. Apart from that, the major enrichment pathways include the citrate cycle, alanine, aspartate, and glutamate metabolism. The enhanced Lac-Phe and La level in the B group was higher than M and C groups. Hunger of the B group immediately after exercise substantially differed from M group. The total ghrelin, glucagon-like peptide-1 and hunger in the B group 1 hour after exercise differed substantially from M group. The results of calorie intake showed no significant difference among the indexes in each group.ConclusionsIn conclusion, this cross-design study demonstrated that the combined MICE and BFR exercise reduced the appetite of obese adults by promoting the secretion of Lac-Phe and ghrelin. However, the exercise did not considerably affect the subsequent ad libitum intake.https://www.frontiersin.org/articles/10.3389/fendo.2023.1289574/fullmoderate-intensity continuous exerciseblood flow restrictionobesityappetite regulationN-lactoylphenylalaninead libitum |
| spellingShingle | Shuoqi Li Rong Guo Juncheng Wang Xinyu Zheng Shuo Zhao Zhiru Zhang Wenbing Yu Shiming Li Peng Zheng The effect of blood flow restriction exercise on N-lactoylphenylalanine and appetite regulation in obese adults: a cross-design study Frontiers in Endocrinology moderate-intensity continuous exercise blood flow restriction obesity appetite regulation N-lactoylphenylalanine ad libitum |
| title | The effect of blood flow restriction exercise on N-lactoylphenylalanine and appetite regulation in obese adults: a cross-design study |
| title_full | The effect of blood flow restriction exercise on N-lactoylphenylalanine and appetite regulation in obese adults: a cross-design study |
| title_fullStr | The effect of blood flow restriction exercise on N-lactoylphenylalanine and appetite regulation in obese adults: a cross-design study |
| title_full_unstemmed | The effect of blood flow restriction exercise on N-lactoylphenylalanine and appetite regulation in obese adults: a cross-design study |
| title_short | The effect of blood flow restriction exercise on N-lactoylphenylalanine and appetite regulation in obese adults: a cross-design study |
| title_sort | effect of blood flow restriction exercise on n lactoylphenylalanine and appetite regulation in obese adults a cross design study |
| topic | moderate-intensity continuous exercise blood flow restriction obesity appetite regulation N-lactoylphenylalanine ad libitum |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1289574/full |
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