Myocardium-Specific Deletion of Rac1 Causes Ventricular Noncompaction and Outflow Tract Defects

Myocardium-Specific Deletion of Rac1 Causes Ventricular Noncompaction and Outflow Tract Defects

Background: Left ventricular noncompaction (LVNC) is a cardiomyopathy that can lead to arrhythmias, embolic events and heart failure. Despite our current knowledge of cardiac development, the mechanisms underlying noncompaction of the ventricular myocardium are still poorly understood. The small GTP...

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Bibliographic Details
Main Authors: Carmen Leung, Anish Engineer, Mella Y. Kim, Xiangru Lu, Qingping Feng
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
<i>Rac1</i>
proliferation
cell polarity
congenital heart defects
compact myocardium
trabeculation
Online Access:https://www.mdpi.com/2308-3425/8/3/29

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