Mechanisms and Clinical Implications of Human Gut Microbiota-Drug Interactions in the Precision Medicine Era
The human gut microbiota, comprising trillions of microorganisms residing in the gastrointestinal tract, has emerged as a pivotal player in modulating various aspects of human health and disease. Recent research has shed light on the intricate relationship between the gut microbiota and pharmaceutic...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-01-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/12/1/194 |
| _version_ | 1797339992074223616 |
|---|---|
| author | Shuaiqi Wang Dianwen Ju Xian Zeng |
| author_facet | Shuaiqi Wang Dianwen Ju Xian Zeng |
| author_sort | Shuaiqi Wang |
| collection | DOAJ |
| description | The human gut microbiota, comprising trillions of microorganisms residing in the gastrointestinal tract, has emerged as a pivotal player in modulating various aspects of human health and disease. Recent research has shed light on the intricate relationship between the gut microbiota and pharmaceuticals, uncovering profound implications for drug metabolism, efficacy, and safety. This review depicted the landscape of molecular mechanisms and clinical implications of dynamic human gut Microbiota-Drug Interactions (MDI), with an emphasis on the impact of MDI on drug responses and individual variations. This review also discussed the therapeutic potential of modulating the gut microbiota or harnessing its metabolic capabilities to optimize clinical treatments and advance personalized medicine, as well as the challenges and future directions in this emerging field. |
| first_indexed | 2024-03-08T09:56:35Z |
| format | Article |
| id | doaj.art-1e69ec53a56b4359bd5679588c0f1e8f |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-08T09:56:35Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-1e69ec53a56b4359bd5679588c0f1e8f2024-01-29T13:47:48ZengMDPI AGBiomedicines2227-90592024-01-0112119410.3390/biomedicines12010194Mechanisms and Clinical Implications of Human Gut Microbiota-Drug Interactions in the Precision Medicine EraShuaiqi Wang0Dianwen Ju1Xian Zeng2Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, Shanghai 201203, ChinaDepartment of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, Shanghai 201203, ChinaDepartment of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, Shanghai 201203, ChinaThe human gut microbiota, comprising trillions of microorganisms residing in the gastrointestinal tract, has emerged as a pivotal player in modulating various aspects of human health and disease. Recent research has shed light on the intricate relationship between the gut microbiota and pharmaceuticals, uncovering profound implications for drug metabolism, efficacy, and safety. This review depicted the landscape of molecular mechanisms and clinical implications of dynamic human gut Microbiota-Drug Interactions (MDI), with an emphasis on the impact of MDI on drug responses and individual variations. This review also discussed the therapeutic potential of modulating the gut microbiota or harnessing its metabolic capabilities to optimize clinical treatments and advance personalized medicine, as well as the challenges and future directions in this emerging field.https://www.mdpi.com/2227-9059/12/1/194gut microbiotaprecision medicinemicrobiota-drug interactiondrug metabolism |
| spellingShingle | Shuaiqi Wang Dianwen Ju Xian Zeng Mechanisms and Clinical Implications of Human Gut Microbiota-Drug Interactions in the Precision Medicine Era Biomedicines gut microbiota precision medicine microbiota-drug interaction drug metabolism |
| title | Mechanisms and Clinical Implications of Human Gut Microbiota-Drug Interactions in the Precision Medicine Era |
| title_full | Mechanisms and Clinical Implications of Human Gut Microbiota-Drug Interactions in the Precision Medicine Era |
| title_fullStr | Mechanisms and Clinical Implications of Human Gut Microbiota-Drug Interactions in the Precision Medicine Era |
| title_full_unstemmed | Mechanisms and Clinical Implications of Human Gut Microbiota-Drug Interactions in the Precision Medicine Era |
| title_short | Mechanisms and Clinical Implications of Human Gut Microbiota-Drug Interactions in the Precision Medicine Era |
| title_sort | mechanisms and clinical implications of human gut microbiota drug interactions in the precision medicine era |
| topic | gut microbiota precision medicine microbiota-drug interaction drug metabolism |
| url | https://www.mdpi.com/2227-9059/12/1/194 |
| work_keys_str_mv | AT shuaiqiwang mechanismsandclinicalimplicationsofhumangutmicrobiotadruginteractionsintheprecisionmedicineera AT dianwenju mechanismsandclinicalimplicationsofhumangutmicrobiotadruginteractionsintheprecisionmedicineera AT xianzeng mechanismsandclinicalimplicationsofhumangutmicrobiotadruginteractionsintheprecisionmedicineera |