Single Nucleotide Polymorphisms and Dental Fluorosis: A Systematic Review
Genetic factors contribute to susceptibility and resistance to fluoride exposure. The aim of this systematic review was to identify alleles/genotypes of single nucleotide polymorphisms (SNPs) associated with dental fluorosis (DF) and to identify them as protective or risk factors. PubMed, ScienceDir...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Dentistry Journal |
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| Online Access: | https://www.mdpi.com/2304-6767/10/11/211 |
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| author | Carlos González-Casamada Martina Nevarez-Rascón Alfredo Nevarez-Rascón María González-Galván Mario Alberto Isiordia-Espinoza Ronell Bologna-Molina Leonor Sánchez-Pérez Nelly Molina-Frechero |
| author_facet | Carlos González-Casamada Martina Nevarez-Rascón Alfredo Nevarez-Rascón María González-Galván Mario Alberto Isiordia-Espinoza Ronell Bologna-Molina Leonor Sánchez-Pérez Nelly Molina-Frechero |
| author_sort | Carlos González-Casamada |
| collection | DOAJ |
| description | Genetic factors contribute to susceptibility and resistance to fluoride exposure. The aim of this systematic review was to identify alleles/genotypes of single nucleotide polymorphisms (SNPs) associated with dental fluorosis (DF) and to identify them as protective or risk factors. PubMed, ScienceDirect, Cochrane Library, Scopus and Web of Science were searched for articles; the last search was performed in August 2022. Human studies that analyzed the relationship between SNPs and DF published in English were included; systematic reviews and meta-analyses were excluded. Methodological quality was graded using the Joanna Briggs Institute checklist and risk of bias was assessed using the Cochrane Collaboration’s tool. Eighteen articles were included, 44% of which showed high methodological quality and data from 5625 participants aged 6 to 75 years were analyzed. The SNPs COL1A2, ESR2, DLX1, DLX2, AMBN, TUFT1, TFIP11, miRNA17, and SOD2 were considered risk factors, and ESR1, MMP20, and ENAM were considered protective factors. In conclusion, there are alleles and genotypes of different single nucleotide polymorphisms involved in increasing or decreasing the risk of developing dental fluorosis. |
| first_indexed | 2024-03-09T19:09:04Z |
| format | Article |
| id | doaj.art-1e6a9d67be194163bb23a343f5b1b5ba |
| institution | Directory Open Access Journal |
| issn | 2304-6767 |
| language | English |
| last_indexed | 2024-03-09T19:09:04Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dentistry Journal |
| spelling | doaj.art-1e6a9d67be194163bb23a343f5b1b5ba2023-11-24T04:17:16ZengMDPI AGDentistry Journal2304-67672022-11-01101121110.3390/dj10110211Single Nucleotide Polymorphisms and Dental Fluorosis: A Systematic ReviewCarlos González-Casamada0Martina Nevarez-Rascón1Alfredo Nevarez-Rascón2María González-Galván3Mario Alberto Isiordia-Espinoza4Ronell Bologna-Molina5Leonor Sánchez-Pérez6Nelly Molina-Frechero7Health Care Department, Autonomous Metropolitan University Xochimilco, Mexico City 04960, MexicoFaculty of Dentistry, Autonomous University of Chihuahua, Chihuahua 31000, MexicoFaculty of Dentistry, Autonomous University of Chihuahua, Chihuahua 31000, MexicoFaculty of Dentistry, National University of Asuncion, Asuncion 1218, ParaguayInstitute of Research in Medical Sciences, Department of Clinics, Los Altos University Center, University of Guadalajara, Tepatitlan de Morelos 47650, Jalisco, MexicoResearch Department, School of Dentistry, Juarez University of the Durango State, Durango 34000, MexicoDivision of Biological and Health Sciences, Autonomous Metropolitan University Xochimilco, Mexico City 04960, MexicoDivision of Biological and Health Sciences, Autonomous Metropolitan University Xochimilco, Mexico City 04960, MexicoGenetic factors contribute to susceptibility and resistance to fluoride exposure. The aim of this systematic review was to identify alleles/genotypes of single nucleotide polymorphisms (SNPs) associated with dental fluorosis (DF) and to identify them as protective or risk factors. PubMed, ScienceDirect, Cochrane Library, Scopus and Web of Science were searched for articles; the last search was performed in August 2022. Human studies that analyzed the relationship between SNPs and DF published in English were included; systematic reviews and meta-analyses were excluded. Methodological quality was graded using the Joanna Briggs Institute checklist and risk of bias was assessed using the Cochrane Collaboration’s tool. Eighteen articles were included, 44% of which showed high methodological quality and data from 5625 participants aged 6 to 75 years were analyzed. The SNPs COL1A2, ESR2, DLX1, DLX2, AMBN, TUFT1, TFIP11, miRNA17, and SOD2 were considered risk factors, and ESR1, MMP20, and ENAM were considered protective factors. In conclusion, there are alleles and genotypes of different single nucleotide polymorphisms involved in increasing or decreasing the risk of developing dental fluorosis.https://www.mdpi.com/2304-6767/10/11/211polymorphismdental fluorosisgene |
| spellingShingle | Carlos González-Casamada Martina Nevarez-Rascón Alfredo Nevarez-Rascón María González-Galván Mario Alberto Isiordia-Espinoza Ronell Bologna-Molina Leonor Sánchez-Pérez Nelly Molina-Frechero Single Nucleotide Polymorphisms and Dental Fluorosis: A Systematic Review Dentistry Journal polymorphism dental fluorosis gene |
| title | Single Nucleotide Polymorphisms and Dental Fluorosis: A Systematic Review |
| title_full | Single Nucleotide Polymorphisms and Dental Fluorosis: A Systematic Review |
| title_fullStr | Single Nucleotide Polymorphisms and Dental Fluorosis: A Systematic Review |
| title_full_unstemmed | Single Nucleotide Polymorphisms and Dental Fluorosis: A Systematic Review |
| title_short | Single Nucleotide Polymorphisms and Dental Fluorosis: A Systematic Review |
| title_sort | single nucleotide polymorphisms and dental fluorosis a systematic review |
| topic | polymorphism dental fluorosis gene |
| url | https://www.mdpi.com/2304-6767/10/11/211 |
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