Assessment of the Opacity of Titanium Dioxide Free Film Coating Formulations
Titanium dioxide (TiO2) is widely used as an excipient in pharmaceutical film coating formulations. In August 2022, the European commission (EC) adopted a ban on the use of TiO2 (E171) as a food additive. There is uncertainty around the implications of this decision on pharmaceutical products, and...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Huddersfield Press
2023-12-01
|
| Series: | British Journal of Pharmacy |
| Subjects: | |
| Online Access: | https://www.bjpharm.org.uk/article/1355/galley/1010/view/ |
| _version_ | 1827380651069800448 |
|---|---|
| author | Alyson Hui Ling Tee Michaela Ogden-Barker Kieran Ellis Sproston |
| author_facet | Alyson Hui Ling Tee Michaela Ogden-Barker Kieran Ellis Sproston |
| author_sort | Alyson Hui Ling Tee |
| collection | DOAJ |
| description |
Titanium dioxide (TiO2) is widely used as an excipient in pharmaceutical film coating formulations. In August 2022, the European commission (EC) adopted a ban on the use of TiO2 (E171) as a food additive. There is uncertainty around the implications of this decision on pharmaceutical products, and a potential need to find suitable alternatives to TiO2. In this study, we evaluated the opacity of the different TF film coating systems by assessing the ability of TF film coatings to mask coloured tablet cores at varying weight gains. HPMC-based film coatings containing CaCO3 demonstrated the best covering potential and were positively correlated to the amount of CaCO3 present, while PVA-based film coatings containing CaCO3showed poor coverage, even at 9% weight gain. |
| first_indexed | 2024-03-08T13:38:00Z |
| format | Article |
| id | doaj.art-1e6c0514d1254633bddc5ff1b7feeeec |
| institution | Directory Open Access Journal |
| issn | 2058-8356 |
| language | English |
| last_indexed | 2024-03-08T13:38:00Z |
| publishDate | 2023-12-01 |
| publisher | University of Huddersfield Press |
| record_format | Article |
| series | British Journal of Pharmacy |
| spelling | doaj.art-1e6c0514d1254633bddc5ff1b7feeeec2024-01-16T14:06:08ZengUniversity of Huddersfield PressBritish Journal of Pharmacy2058-83562023-12-018210.5920/bjpharm.1355Assessment of the Opacity of Titanium Dioxide Free Film Coating FormulationsAlyson Hui Ling Tee0Michaela Ogden-Barker1Kieran Ellis Sproston2PfizerPfizerPfizer Titanium dioxide (TiO2) is widely used as an excipient in pharmaceutical film coating formulations. In August 2022, the European commission (EC) adopted a ban on the use of TiO2 (E171) as a food additive. There is uncertainty around the implications of this decision on pharmaceutical products, and a potential need to find suitable alternatives to TiO2. In this study, we evaluated the opacity of the different TF film coating systems by assessing the ability of TF film coatings to mask coloured tablet cores at varying weight gains. HPMC-based film coatings containing CaCO3 demonstrated the best covering potential and were positively correlated to the amount of CaCO3 present, while PVA-based film coatings containing CaCO3showed poor coverage, even at 9% weight gain. https://www.bjpharm.org.uk/article/1355/galley/1010/view/tio2tio2-freefilm coatingtitanium dioxideopacity |
| spellingShingle | Alyson Hui Ling Tee Michaela Ogden-Barker Kieran Ellis Sproston Assessment of the Opacity of Titanium Dioxide Free Film Coating Formulations British Journal of Pharmacy tio2 tio2-free film coating titanium dioxide opacity |
| title | Assessment of the Opacity of Titanium Dioxide Free Film Coating Formulations |
| title_full | Assessment of the Opacity of Titanium Dioxide Free Film Coating Formulations |
| title_fullStr | Assessment of the Opacity of Titanium Dioxide Free Film Coating Formulations |
| title_full_unstemmed | Assessment of the Opacity of Titanium Dioxide Free Film Coating Formulations |
| title_short | Assessment of the Opacity of Titanium Dioxide Free Film Coating Formulations |
| title_sort | assessment of the opacity of titanium dioxide free film coating formulations |
| topic | tio2 tio2-free film coating titanium dioxide opacity |
| url | https://www.bjpharm.org.uk/article/1355/galley/1010/view/ |
| work_keys_str_mv | AT alysonhuilingtee assessmentoftheopacityoftitaniumdioxidefreefilmcoatingformulations AT michaelaogdenbarker assessmentoftheopacityoftitaniumdioxidefreefilmcoatingformulations AT kieranellissproston assessmentoftheopacityoftitaniumdioxidefreefilmcoatingformulations |