Directional induction of neural stem cells, a new therapy for neurodegenerative diseases and ischemic stroke
Abstract Due to the limited capacity of the adult mammalian brain to self-repair and regenerate, neurological diseases, especially neurodegenerative disorders and stroke, characterized by irreversible cellular damage are often considered as refractory diseases. Neural stem cells (NSCs) play a unique...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-07-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-023-01532-9 |
| _version_ | 1797789897108488192 |
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| author | Luwei Nie Dabao Yao Shiling Chen Jingyi Wang Chao Pan Dongcheng Wu Na Liu Zhouping Tang |
| author_facet | Luwei Nie Dabao Yao Shiling Chen Jingyi Wang Chao Pan Dongcheng Wu Na Liu Zhouping Tang |
| author_sort | Luwei Nie |
| collection | DOAJ |
| description | Abstract Due to the limited capacity of the adult mammalian brain to self-repair and regenerate, neurological diseases, especially neurodegenerative disorders and stroke, characterized by irreversible cellular damage are often considered as refractory diseases. Neural stem cells (NSCs) play a unique role in the treatment of neurological diseases for their abilities to self-renew and form different neural lineage cells, such as neurons and glial cells. With the increasing understanding of neurodevelopment and advances in stem cell technology, NSCs can be obtained from different sources and directed to differentiate into a specific neural lineage cell phenotype purposefully, making it possible to replace specific cells lost in some neurological diseases, which provides new approaches to treat neurodegenerative diseases as well as stroke. In this review, we outline the advances in generating several neuronal lineage subtypes from different sources of NSCs. We further summarize the therapeutic effects and possible therapeutic mechanisms of these fated specific NSCs in neurological disease models, with special emphasis on Parkinson’s disease and ischemic stroke. Finally, from the perspective of clinical translation, we compare the strengths and weaknesses of different sources of NSCs and different methods of directed differentiation, and propose future research directions for directed differentiation of NSCs in regenerative medicine. |
| first_indexed | 2024-03-13T01:57:07Z |
| format | Article |
| id | doaj.art-1e6f57d9e4824b36a50d55d9a9da7c13 |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-03-13T01:57:07Z |
| publishDate | 2023-07-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-1e6f57d9e4824b36a50d55d9a9da7c132023-07-02T11:07:32ZengNature Publishing GroupCell Death Discovery2058-77162023-07-019112210.1038/s41420-023-01532-9Directional induction of neural stem cells, a new therapy for neurodegenerative diseases and ischemic strokeLuwei Nie0Dabao Yao1Shiling Chen2Jingyi Wang3Chao Pan4Dongcheng Wu5Na Liu6Zhouping Tang7Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Biochemistry and Molecular Biology, Wuhan University School of Basic Medical SciencesDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Due to the limited capacity of the adult mammalian brain to self-repair and regenerate, neurological diseases, especially neurodegenerative disorders and stroke, characterized by irreversible cellular damage are often considered as refractory diseases. Neural stem cells (NSCs) play a unique role in the treatment of neurological diseases for their abilities to self-renew and form different neural lineage cells, such as neurons and glial cells. With the increasing understanding of neurodevelopment and advances in stem cell technology, NSCs can be obtained from different sources and directed to differentiate into a specific neural lineage cell phenotype purposefully, making it possible to replace specific cells lost in some neurological diseases, which provides new approaches to treat neurodegenerative diseases as well as stroke. In this review, we outline the advances in generating several neuronal lineage subtypes from different sources of NSCs. We further summarize the therapeutic effects and possible therapeutic mechanisms of these fated specific NSCs in neurological disease models, with special emphasis on Parkinson’s disease and ischemic stroke. Finally, from the perspective of clinical translation, we compare the strengths and weaknesses of different sources of NSCs and different methods of directed differentiation, and propose future research directions for directed differentiation of NSCs in regenerative medicine.https://doi.org/10.1038/s41420-023-01532-9 |
| spellingShingle | Luwei Nie Dabao Yao Shiling Chen Jingyi Wang Chao Pan Dongcheng Wu Na Liu Zhouping Tang Directional induction of neural stem cells, a new therapy for neurodegenerative diseases and ischemic stroke Cell Death Discovery |
| title | Directional induction of neural stem cells, a new therapy for neurodegenerative diseases and ischemic stroke |
| title_full | Directional induction of neural stem cells, a new therapy for neurodegenerative diseases and ischemic stroke |
| title_fullStr | Directional induction of neural stem cells, a new therapy for neurodegenerative diseases and ischemic stroke |
| title_full_unstemmed | Directional induction of neural stem cells, a new therapy for neurodegenerative diseases and ischemic stroke |
| title_short | Directional induction of neural stem cells, a new therapy for neurodegenerative diseases and ischemic stroke |
| title_sort | directional induction of neural stem cells a new therapy for neurodegenerative diseases and ischemic stroke |
| url | https://doi.org/10.1038/s41420-023-01532-9 |
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