EVA1A, a novel and promising prognostic biomarker in colorectal cancer
PurposeThe purpose of this study was to investigate the potential of EVA1A as a prognostic biomarker for Colorectal cancer (CRC).MethodsThe study utilized public databases to analyze the difference in Evala mRNA expression between CRC tumor tissues and adjacent normal tissues. Additionallymunohistoc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1333702/full |
| _version_ | 1797266406749765632 |
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| author | Hai-hua Fan Hai-jun Zhang |
| author_facet | Hai-hua Fan Hai-jun Zhang |
| author_sort | Hai-hua Fan |
| collection | DOAJ |
| description | PurposeThe purpose of this study was to investigate the potential of EVA1A as a prognostic biomarker for Colorectal cancer (CRC).MethodsThe study utilized public databases to analyze the difference in Evala mRNA expression between CRC tumor tissues and adjacent normal tissues. Additionallymunohistochemical staining was performed on 90 paired tissue samples to detect EVA1A expression. The relationship between EVA1A and clinicopathological features was examined, and a Kaplan-Meier survival analysis was conducted. Univariate and multivariate Cox analyses were employed to identify prognostic factors affecting the overall survival (OS) of CRC patients.ResultsThe analysis revealed a significant increase in Evala mRNA expression in CRC tumor cells compared to normal controls from public databases (P< 0.05). Immunohistochemical staining further confirmed a significant upregulation of EVA1A expression in CRC tissues (P< 0.05). High EVA1A expression was associated with age, pathological M stage, total tumor stage, and Carbohydrate antigen CA19-9 (CA19-9). Kaplan-Meier analysis demonstrated a significant association between high EVA1A expression and poor OS. Univariate and multivariate analysis identified EVA1A as an independent risk factor for CRC prognosis.ConclusionThe study suggests that EVA1A is increased in CRC tumor tissues and may serve as a potential biomarker for poor prognosis in CRC. |
| first_indexed | 2024-04-25T01:00:11Z |
| format | Article |
| id | doaj.art-1e7083c742bb49bea5290a4295bc24c0 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-25T01:00:11Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-1e7083c742bb49bea5290a4295bc24c02024-03-11T05:03:55ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-03-011410.3389/fonc.2024.13337021333702EVA1A, a novel and promising prognostic biomarker in colorectal cancerHai-hua Fan0Hai-jun Zhang1Department of Oncology, The Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu, ChinaDepartment of Oncology, The Affiliated Zhongda Hospital of Southeast University, Medical School of Southeast University, Nanjing, Jiangsu, ChinaPurposeThe purpose of this study was to investigate the potential of EVA1A as a prognostic biomarker for Colorectal cancer (CRC).MethodsThe study utilized public databases to analyze the difference in Evala mRNA expression between CRC tumor tissues and adjacent normal tissues. Additionallymunohistochemical staining was performed on 90 paired tissue samples to detect EVA1A expression. The relationship between EVA1A and clinicopathological features was examined, and a Kaplan-Meier survival analysis was conducted. Univariate and multivariate Cox analyses were employed to identify prognostic factors affecting the overall survival (OS) of CRC patients.ResultsThe analysis revealed a significant increase in Evala mRNA expression in CRC tumor cells compared to normal controls from public databases (P< 0.05). Immunohistochemical staining further confirmed a significant upregulation of EVA1A expression in CRC tissues (P< 0.05). High EVA1A expression was associated with age, pathological M stage, total tumor stage, and Carbohydrate antigen CA19-9 (CA19-9). Kaplan-Meier analysis demonstrated a significant association between high EVA1A expression and poor OS. Univariate and multivariate analysis identified EVA1A as an independent risk factor for CRC prognosis.ConclusionThe study suggests that EVA1A is increased in CRC tumor tissues and may serve as a potential biomarker for poor prognosis in CRC.https://www.frontiersin.org/articles/10.3389/fonc.2024.1333702/fullcolorectal cancerEva-1 homolog Aprognosisbiomarkeroverall survival |
| spellingShingle | Hai-hua Fan Hai-jun Zhang EVA1A, a novel and promising prognostic biomarker in colorectal cancer Frontiers in Oncology colorectal cancer Eva-1 homolog A prognosis biomarker overall survival |
| title | EVA1A, a novel and promising prognostic biomarker in colorectal cancer |
| title_full | EVA1A, a novel and promising prognostic biomarker in colorectal cancer |
| title_fullStr | EVA1A, a novel and promising prognostic biomarker in colorectal cancer |
| title_full_unstemmed | EVA1A, a novel and promising prognostic biomarker in colorectal cancer |
| title_short | EVA1A, a novel and promising prognostic biomarker in colorectal cancer |
| title_sort | eva1a a novel and promising prognostic biomarker in colorectal cancer |
| topic | colorectal cancer Eva-1 homolog A prognosis biomarker overall survival |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1333702/full |
| work_keys_str_mv | AT haihuafan eva1aanovelandpromisingprognosticbiomarkerincolorectalcancer AT haijunzhang eva1aanovelandpromisingprognosticbiomarkerincolorectalcancer |