A molecular device: A DNA molecular lock driven by the nicking enzymes
As people are placing more and more importance on information security, how to realize the protection of information has become a hotspot of current research. As a security device, DNA molecular locks have great potential to realize information protection at the molecular level. However, building a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Computational and Structural Biotechnology Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037020303573 |
| _version_ | 1828886374657294336 |
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| author | Xiaokang Zhang Qiang Zhang Yuan Liu Bin Wang Shihua Zhou |
| author_facet | Xiaokang Zhang Qiang Zhang Yuan Liu Bin Wang Shihua Zhou |
| author_sort | Xiaokang Zhang |
| collection | DOAJ |
| description | As people are placing more and more importance on information security, how to realize the protection of information has become a hotspot of current research. As a security device, DNA molecular locks have great potential to realize information protection at the molecular level. However, building a highly secure molecular lock is still a serious challenge. Therefore, taking advantage of the DNA strand displacement and enzyme control technology, we constructed a molecular lock with a self-destructive mechanism. This molecular lock is mainly composed of logic circuits and takes nicking enzymes as inputs. To build this molecular lock, we first constructed a series of cascade circuits, including a YES–YES cascade circuit and a YES–AND cascade circuit. Then, an Inhibit logic gate was constructed to explore the inhibitory properties between different combinations of two nicking enzymes. Finally, using the characteristics of mutual inhibition between several enzymes, a DNA molecular lock driven by three nicking enzymes was constructed. In this molecular device, only the correct sequence of nicking enzymes can be input to ensure the normal operation of the molecular lock. Once the wrong password is entered, the device will be destroyed and cannot be recovered, which effectively prevents intruders from cracking the lock through exhaustive methods. The molecular lock has the function of simulating an electronic keyboard, which can realize the protection of information at the molecular level, and provides a new implementation method for building more advanced and complex molecular devices. |
| first_indexed | 2024-12-13T11:43:02Z |
| format | Article |
| id | doaj.art-1e731894aeb0481d8a7973e189d2f02b |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-12-13T11:43:02Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-1e731894aeb0481d8a7973e189d2f02b2022-12-21T23:47:34ZengElsevierComputational and Structural Biotechnology Journal2001-03702020-01-011821072116A molecular device: A DNA molecular lock driven by the nicking enzymesXiaokang Zhang0Qiang Zhang1Yuan Liu2Bin Wang3Shihua Zhou4Key Laboratory of Advanced Design and Intelligent Computing, Ministry of Education, School of Software Engineering, Dalian University, Dalian 116622, ChinaKey Laboratory of Advanced Design and Intelligent Computing, Ministry of Education, School of Software Engineering, Dalian University, Dalian 116622, China; School of Computer Science and Technology, Dalian University of Technology, Dalian 116024, China; Corresponding author at: Key Laboratory of Advanced Design and Intelligent Computing, Ministry of Education, School of Software Engineering, Dalian University, Dalian 116622, China.School of Computer Science and Technology, Dalian University of Technology, Dalian 116024, ChinaKey Laboratory of Advanced Design and Intelligent Computing, Ministry of Education, School of Software Engineering, Dalian University, Dalian 116622, ChinaKey Laboratory of Advanced Design and Intelligent Computing, Ministry of Education, School of Software Engineering, Dalian University, Dalian 116622, ChinaAs people are placing more and more importance on information security, how to realize the protection of information has become a hotspot of current research. As a security device, DNA molecular locks have great potential to realize information protection at the molecular level. However, building a highly secure molecular lock is still a serious challenge. Therefore, taking advantage of the DNA strand displacement and enzyme control technology, we constructed a molecular lock with a self-destructive mechanism. This molecular lock is mainly composed of logic circuits and takes nicking enzymes as inputs. To build this molecular lock, we first constructed a series of cascade circuits, including a YES–YES cascade circuit and a YES–AND cascade circuit. Then, an Inhibit logic gate was constructed to explore the inhibitory properties between different combinations of two nicking enzymes. Finally, using the characteristics of mutual inhibition between several enzymes, a DNA molecular lock driven by three nicking enzymes was constructed. In this molecular device, only the correct sequence of nicking enzymes can be input to ensure the normal operation of the molecular lock. Once the wrong password is entered, the device will be destroyed and cannot be recovered, which effectively prevents intruders from cracking the lock through exhaustive methods. The molecular lock has the function of simulating an electronic keyboard, which can realize the protection of information at the molecular level, and provides a new implementation method for building more advanced and complex molecular devices.http://www.sciencedirect.com/science/article/pii/S2001037020303573DNAInformation SecurityMolecular LockNicking Enzyme |
| spellingShingle | Xiaokang Zhang Qiang Zhang Yuan Liu Bin Wang Shihua Zhou A molecular device: A DNA molecular lock driven by the nicking enzymes Computational and Structural Biotechnology Journal DNA Information Security Molecular Lock Nicking Enzyme |
| title | A molecular device: A DNA molecular lock driven by the nicking enzymes |
| title_full | A molecular device: A DNA molecular lock driven by the nicking enzymes |
| title_fullStr | A molecular device: A DNA molecular lock driven by the nicking enzymes |
| title_full_unstemmed | A molecular device: A DNA molecular lock driven by the nicking enzymes |
| title_short | A molecular device: A DNA molecular lock driven by the nicking enzymes |
| title_sort | molecular device a dna molecular lock driven by the nicking enzymes |
| topic | DNA Information Security Molecular Lock Nicking Enzyme |
| url | http://www.sciencedirect.com/science/article/pii/S2001037020303573 |
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