Association of cigarette smoking with oral bacterial microbiota and cardiometabolic health in Chinese adults
Abstract The interplay among cigarette smoking status, oral microbiota, and cardiometabolic health is poorly understood. We aimed to examine the association of cigarette smoking status with oral microbiota and to assess the association of the identified microbial features with cardiometabolic risk f...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Microbiology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12866-023-03061-y |
| _version_ | 1827724245239595008 |
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| author | Qiumin Huang Xuemei Wu Xiaofeng Zhou Zhonghan Sun Jie Shen Mengmeng Kong Nannan Chen Jian-Ge Qiu Bing-Hua Jiang Changzheng Yuan Yan Zheng |
| author_facet | Qiumin Huang Xuemei Wu Xiaofeng Zhou Zhonghan Sun Jie Shen Mengmeng Kong Nannan Chen Jian-Ge Qiu Bing-Hua Jiang Changzheng Yuan Yan Zheng |
| author_sort | Qiumin Huang |
| collection | DOAJ |
| description | Abstract The interplay among cigarette smoking status, oral microbiota, and cardiometabolic health is poorly understood. We aimed to examine the association of cigarette smoking status with oral microbiota and to assess the association of the identified microbial features with cardiometabolic risk factors in a Chinese population. This study included 587 participants within the Central China Cohort, including 111 smokers and 476 non-smokers, and their oral microbiota was profiled by 16S rRNA sequencing. Both oral microbial alpha- and beta-diversity were distinct between smokers and non-smokers (p < 0.05). With adjustment for sociodemographics, alcohol and tea drinking, tooth brushing frequency, and body mass index, the relative abundance of nine genera and 26 pathways, including the genus Megasphaera and two pathways involved in inositol degradation which have potentially adverse effects on cardiometabolic health, was significantly different between two groups (FDR q < 0.20). Multiple microbial features related to cigarette smoking were found to partly mediate the associations of cigarette smoking with serum triglycerides and C-reactive protein levels (p-mediation < 0.05). In conclusion, cigarette smoking status may have impacts on the oral microbial features, which may partially mediate the associations of cigarette smoking and cardiometabolic health. |
| first_indexed | 2024-03-10T22:13:03Z |
| format | Article |
| id | doaj.art-1e73344cc6b8443d881eb8553fcaff46 |
| institution | Directory Open Access Journal |
| issn | 1471-2180 |
| language | English |
| last_indexed | 2024-03-10T22:13:03Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Microbiology |
| spelling | doaj.art-1e73344cc6b8443d881eb8553fcaff462023-11-19T12:32:45ZengBMCBMC Microbiology1471-21802023-11-0123111110.1186/s12866-023-03061-yAssociation of cigarette smoking with oral bacterial microbiota and cardiometabolic health in Chinese adultsQiumin Huang0Xuemei Wu1Xiaofeng Zhou2Zhonghan Sun3Jie Shen4Mengmeng Kong5Nannan Chen6Jian-Ge Qiu7Bing-Hua Jiang8Changzheng Yuan9Yan Zheng10School of Life Sciences and Human Phenome Institute, Fudan UniversitySchool of Public Health, Fudan UniversitySchool of Life Sciences and Human Phenome Institute, Fudan UniversitySchool of Life Sciences and Human Phenome Institute, Fudan UniversitySchool of Public Health, Zhejiang University School of MedicineSchool of Life Sciences and Human Phenome Institute, Fudan UniversitySchool of Medicine, Nantong UniversityThe Academy of Medical Science, Zhengzhou UniversityThe Academy of Medical Science, Zhengzhou UniversitySchool of Public Health, Zhejiang University School of MedicineSchool of Life Sciences and Human Phenome Institute, Fudan UniversityAbstract The interplay among cigarette smoking status, oral microbiota, and cardiometabolic health is poorly understood. We aimed to examine the association of cigarette smoking status with oral microbiota and to assess the association of the identified microbial features with cardiometabolic risk factors in a Chinese population. This study included 587 participants within the Central China Cohort, including 111 smokers and 476 non-smokers, and their oral microbiota was profiled by 16S rRNA sequencing. Both oral microbial alpha- and beta-diversity were distinct between smokers and non-smokers (p < 0.05). With adjustment for sociodemographics, alcohol and tea drinking, tooth brushing frequency, and body mass index, the relative abundance of nine genera and 26 pathways, including the genus Megasphaera and two pathways involved in inositol degradation which have potentially adverse effects on cardiometabolic health, was significantly different between two groups (FDR q < 0.20). Multiple microbial features related to cigarette smoking were found to partly mediate the associations of cigarette smoking with serum triglycerides and C-reactive protein levels (p-mediation < 0.05). In conclusion, cigarette smoking status may have impacts on the oral microbial features, which may partially mediate the associations of cigarette smoking and cardiometabolic health.https://doi.org/10.1186/s12866-023-03061-yOral microbiomeCigaretteSmokingCardiometabolic healthChinese adults |
| spellingShingle | Qiumin Huang Xuemei Wu Xiaofeng Zhou Zhonghan Sun Jie Shen Mengmeng Kong Nannan Chen Jian-Ge Qiu Bing-Hua Jiang Changzheng Yuan Yan Zheng Association of cigarette smoking with oral bacterial microbiota and cardiometabolic health in Chinese adults BMC Microbiology Oral microbiome Cigarette Smoking Cardiometabolic health Chinese adults |
| title | Association of cigarette smoking with oral bacterial microbiota and cardiometabolic health in Chinese adults |
| title_full | Association of cigarette smoking with oral bacterial microbiota and cardiometabolic health in Chinese adults |
| title_fullStr | Association of cigarette smoking with oral bacterial microbiota and cardiometabolic health in Chinese adults |
| title_full_unstemmed | Association of cigarette smoking with oral bacterial microbiota and cardiometabolic health in Chinese adults |
| title_short | Association of cigarette smoking with oral bacterial microbiota and cardiometabolic health in Chinese adults |
| title_sort | association of cigarette smoking with oral bacterial microbiota and cardiometabolic health in chinese adults |
| topic | Oral microbiome Cigarette Smoking Cardiometabolic health Chinese adults |
| url | https://doi.org/10.1186/s12866-023-03061-y |
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