The Application of Embelin for Cancer Prevention and Therapy
Embelin is a naturally-occurring benzoquinone compound that has been shown to possess many biological properties relevant to human cancer prevention and treatment, and increasing evidence indicates that embelin may modulate various characteristic hallmarks of tumor cells. This review summarizes the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-03-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/23/3/621 |
| _version_ | 1811258826628792320 |
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| author | Jeong-Hyeon Ko Seok-Geun Lee Woong Mo Yang Jae-Young Um Gautam Sethi Srishti Mishra Muthu K. Shanmugam Kwang Seok Ahn |
| author_facet | Jeong-Hyeon Ko Seok-Geun Lee Woong Mo Yang Jae-Young Um Gautam Sethi Srishti Mishra Muthu K. Shanmugam Kwang Seok Ahn |
| author_sort | Jeong-Hyeon Ko |
| collection | DOAJ |
| description | Embelin is a naturally-occurring benzoquinone compound that has been shown to possess many biological properties relevant to human cancer prevention and treatment, and increasing evidence indicates that embelin may modulate various characteristic hallmarks of tumor cells. This review summarizes the information related to the various oncogenic pathways that mediate embelin-induced cell death in multiple cancer cells. The mechanisms of the action of embelin are numerous, and most of them induce apoptotic cell death that may be intrinsic or extrinsic, and modulate the NF-κB, p53, PI3K/AKT, and STAT3 signaling pathways. Embelin also induces autophagy in cancer cells; however, these autophagic cell-death mechanisms of embelin have been less reported than the apoptotic ones. Recently, several autophagy-inducing agents have been used in the treatment of different human cancers, although they require further exploration before being transferred from the bench to the clinic. Therefore, embelin could be used as a potential agent for cancer therapy. |
| first_indexed | 2024-04-12T18:20:22Z |
| format | Article |
| id | doaj.art-1e7365113b024ae1920dafeb2785e81d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T18:20:22Z |
| publishDate | 2018-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1e7365113b024ae1920dafeb2785e81d2022-12-22T03:21:27ZengMDPI AGMolecules1420-30492018-03-0123362110.3390/molecules23030621molecules23030621The Application of Embelin for Cancer Prevention and TherapyJeong-Hyeon Ko0Seok-Geun Lee1Woong Mo Yang2Jae-Young Um3Gautam Sethi4Srishti Mishra5Muthu K. Shanmugam6Kwang Seok Ahn7College of Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaCollege of Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaCollege of Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaCollege of Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City 700000, VietnamDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeCollege of Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaEmbelin is a naturally-occurring benzoquinone compound that has been shown to possess many biological properties relevant to human cancer prevention and treatment, and increasing evidence indicates that embelin may modulate various characteristic hallmarks of tumor cells. This review summarizes the information related to the various oncogenic pathways that mediate embelin-induced cell death in multiple cancer cells. The mechanisms of the action of embelin are numerous, and most of them induce apoptotic cell death that may be intrinsic or extrinsic, and modulate the NF-κB, p53, PI3K/AKT, and STAT3 signaling pathways. Embelin also induces autophagy in cancer cells; however, these autophagic cell-death mechanisms of embelin have been less reported than the apoptotic ones. Recently, several autophagy-inducing agents have been used in the treatment of different human cancers, although they require further exploration before being transferred from the bench to the clinic. Therefore, embelin could be used as a potential agent for cancer therapy.http://www.mdpi.com/1420-3049/23/3/621Embelinapoptosisautophagycancercell signaling |
| spellingShingle | Jeong-Hyeon Ko Seok-Geun Lee Woong Mo Yang Jae-Young Um Gautam Sethi Srishti Mishra Muthu K. Shanmugam Kwang Seok Ahn The Application of Embelin for Cancer Prevention and Therapy Molecules Embelin apoptosis autophagy cancer cell signaling |
| title | The Application of Embelin for Cancer Prevention and Therapy |
| title_full | The Application of Embelin for Cancer Prevention and Therapy |
| title_fullStr | The Application of Embelin for Cancer Prevention and Therapy |
| title_full_unstemmed | The Application of Embelin for Cancer Prevention and Therapy |
| title_short | The Application of Embelin for Cancer Prevention and Therapy |
| title_sort | application of embelin for cancer prevention and therapy |
| topic | Embelin apoptosis autophagy cancer cell signaling |
| url | http://www.mdpi.com/1420-3049/23/3/621 |
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