CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells.
The association between the host immune environment and the size of the HIV reservoir during effective antiretroviral therapy is not clear. Progress has also been limited by the lack of a well-accepted assay for quantifying HIV during therapy. We examined the association between multiple measurement...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4207702?pdf=render |
| _version_ | 1818859147591942144 |
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| author | Leslie R Cockerham Janet D Siliciano Elizabeth Sinclair Una O'Doherty Sarah Palmer Steven A Yukl Matt C Strain Nicolas Chomont Frederick M Hecht Robert F Siliciano Douglas D Richman Steven G Deeks |
| author_facet | Leslie R Cockerham Janet D Siliciano Elizabeth Sinclair Una O'Doherty Sarah Palmer Steven A Yukl Matt C Strain Nicolas Chomont Frederick M Hecht Robert F Siliciano Douglas D Richman Steven G Deeks |
| author_sort | Leslie R Cockerham |
| collection | DOAJ |
| description | The association between the host immune environment and the size of the HIV reservoir during effective antiretroviral therapy is not clear. Progress has also been limited by the lack of a well-accepted assay for quantifying HIV during therapy. We examined the association between multiple measurements of HIV and T cell activation (as defined by markers including CD38, HLA-DR, CCR5 and PD-1) in 30 antiretroviral-treated HIV-infected adults. We found a consistent association between the frequency of CD4+ and CD8+ T cells expressing HLA-DR and the frequency of resting CD4+ T cells containing HIV DNA. This study highlights the need to further examine this relationship and to better characterize the biology of markers commonly used in HIV studies. These results may also have implications for reactivation strategies. |
| first_indexed | 2024-12-19T09:07:34Z |
| format | Article |
| id | doaj.art-1e7531bea7b24e95bf6896df3079271e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T09:07:34Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1e7531bea7b24e95bf6896df3079271e2022-12-21T20:28:17ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01910e11073110.1371/journal.pone.0110731CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells.Leslie R CockerhamJanet D SilicianoElizabeth SinclairUna O'DohertySarah PalmerSteven A YuklMatt C StrainNicolas ChomontFrederick M HechtRobert F SilicianoDouglas D RichmanSteven G DeeksThe association between the host immune environment and the size of the HIV reservoir during effective antiretroviral therapy is not clear. Progress has also been limited by the lack of a well-accepted assay for quantifying HIV during therapy. We examined the association between multiple measurements of HIV and T cell activation (as defined by markers including CD38, HLA-DR, CCR5 and PD-1) in 30 antiretroviral-treated HIV-infected adults. We found a consistent association between the frequency of CD4+ and CD8+ T cells expressing HLA-DR and the frequency of resting CD4+ T cells containing HIV DNA. This study highlights the need to further examine this relationship and to better characterize the biology of markers commonly used in HIV studies. These results may also have implications for reactivation strategies.http://europepmc.org/articles/PMC4207702?pdf=render |
| spellingShingle | Leslie R Cockerham Janet D Siliciano Elizabeth Sinclair Una O'Doherty Sarah Palmer Steven A Yukl Matt C Strain Nicolas Chomont Frederick M Hecht Robert F Siliciano Douglas D Richman Steven G Deeks CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells. PLoS ONE |
| title | CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells. |
| title_full | CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells. |
| title_fullStr | CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells. |
| title_full_unstemmed | CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells. |
| title_short | CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells. |
| title_sort | cd4 and cd8 t cell activation are associated with hiv dna in resting cd4 t cells |
| url | http://europepmc.org/articles/PMC4207702?pdf=render |
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