Association of Uremic Toxins and Inflammatory Markers with Physical Performance in Dialysis Patients
Association of higher serum levels of uremic toxins and inflammatory markers with poorer physical performance is understudied. We measured the six-minute walk test (6MWT), 10 repetition sit-to-stand test (STS-10), handgrip strength (HGS), and Human Activity Profile (HAP) questionnaire score in 90 pr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-10-01
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| Series: | Toxins |
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| Online Access: | http://www.mdpi.com/2072-6651/10/10/403 |
| _version_ | 1798041577335029760 |
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| author | Maja Pajek Alexander Jerman Joško Osredkar Jadranka Buturović Ponikvar Jernej Pajek |
| author_facet | Maja Pajek Alexander Jerman Joško Osredkar Jadranka Buturović Ponikvar Jernej Pajek |
| author_sort | Maja Pajek |
| collection | DOAJ |
| description | Association of higher serum levels of uremic toxins and inflammatory markers with poorer physical performance is understudied. We measured the six-minute walk test (6MWT), 10 repetition sit-to-stand test (STS-10), handgrip strength (HGS), and Human Activity Profile (HAP) questionnaire score in 90 prevalent hemodialysis patents, with low comorbidity to reduce the potential confounding of concomitant disease. Midweek pre-dialysis serum levels of asymmetric dimethyl-arginine (ADMA), β2-microglobulin (B2M), high-sensitivity C-reactive protein (hs-CRP), indoxyl sulfate (IS), insulin-like growth factor 1 (IGF-1), interleukin 6 (IL-6), myostatin, and urea were analyzed as predictor parameters of physical performance measures in adjusted models. Serum levels of most measured toxins were not significantly related to performance, except for ADMA, which was significantly related to poorer performance in the STS-10 test (B = 0.11 ± 0.03 s, p < 0.01). Higher hs-CRP was associated with poorer results in the 6MWT (B = −2.6 ± 0.97 m, p < 0.01) and a lower HAP score (B = −0.36 ± 0.14, p = 0.01). There were no other significant associations found. We conclude that inflammation may be a more important pathway to physical impediment than uremic toxemia. This suggests that there is a large physical rehabilitation potential in non-inflamed uremic patients. |
| first_indexed | 2024-04-11T22:24:14Z |
| format | Article |
| id | doaj.art-1e75899214914603abb2cd2572a022ee |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T22:24:14Z |
| publishDate | 2018-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-1e75899214914603abb2cd2572a022ee2022-12-22T03:59:54ZengMDPI AGToxins2072-66512018-10-01101040310.3390/toxins10100403toxins10100403Association of Uremic Toxins and Inflammatory Markers with Physical Performance in Dialysis PatientsMaja Pajek0Alexander Jerman1Joško Osredkar2Jadranka Buturović Ponikvar3Jernej Pajek4Faculty of Sport, University of Ljubljana, Gortanova 22, 1000 Ljubljana, SloveniaDepartment of Nephrology, University Medical Centre Ljubljana, Zaloška 2, 1525 Ljubljana, SloveniaClinical Institute for Clinical Chemistry and Biochemistry, University Medical Centre Ljubljana, Zaloška 2, 1525 Ljubljana, SloveniaDepartment of Nephrology, University Medical Centre Ljubljana, Zaloška 2, 1525 Ljubljana, SloveniaDepartment of Nephrology, University Medical Centre Ljubljana, Zaloška 2, 1525 Ljubljana, SloveniaAssociation of higher serum levels of uremic toxins and inflammatory markers with poorer physical performance is understudied. We measured the six-minute walk test (6MWT), 10 repetition sit-to-stand test (STS-10), handgrip strength (HGS), and Human Activity Profile (HAP) questionnaire score in 90 prevalent hemodialysis patents, with low comorbidity to reduce the potential confounding of concomitant disease. Midweek pre-dialysis serum levels of asymmetric dimethyl-arginine (ADMA), β2-microglobulin (B2M), high-sensitivity C-reactive protein (hs-CRP), indoxyl sulfate (IS), insulin-like growth factor 1 (IGF-1), interleukin 6 (IL-6), myostatin, and urea were analyzed as predictor parameters of physical performance measures in adjusted models. Serum levels of most measured toxins were not significantly related to performance, except for ADMA, which was significantly related to poorer performance in the STS-10 test (B = 0.11 ± 0.03 s, p < 0.01). Higher hs-CRP was associated with poorer results in the 6MWT (B = −2.6 ± 0.97 m, p < 0.01) and a lower HAP score (B = −0.36 ± 0.14, p = 0.01). There were no other significant associations found. We conclude that inflammation may be a more important pathway to physical impediment than uremic toxemia. This suggests that there is a large physical rehabilitation potential in non-inflamed uremic patients.http://www.mdpi.com/2072-6651/10/10/403hemodialysis6-minute walk testsit-to-stand testhandgrip strengthHuman Activity Profilesarcopeniamuscleasymmetric dimethyl-arginineC-reactive proteinmotor ability |
| spellingShingle | Maja Pajek Alexander Jerman Joško Osredkar Jadranka Buturović Ponikvar Jernej Pajek Association of Uremic Toxins and Inflammatory Markers with Physical Performance in Dialysis Patients Toxins hemodialysis 6-minute walk test sit-to-stand test handgrip strength Human Activity Profile sarcopenia muscle asymmetric dimethyl-arginine C-reactive protein motor ability |
| title | Association of Uremic Toxins and Inflammatory Markers with Physical Performance in Dialysis Patients |
| title_full | Association of Uremic Toxins and Inflammatory Markers with Physical Performance in Dialysis Patients |
| title_fullStr | Association of Uremic Toxins and Inflammatory Markers with Physical Performance in Dialysis Patients |
| title_full_unstemmed | Association of Uremic Toxins and Inflammatory Markers with Physical Performance in Dialysis Patients |
| title_short | Association of Uremic Toxins and Inflammatory Markers with Physical Performance in Dialysis Patients |
| title_sort | association of uremic toxins and inflammatory markers with physical performance in dialysis patients |
| topic | hemodialysis 6-minute walk test sit-to-stand test handgrip strength Human Activity Profile sarcopenia muscle asymmetric dimethyl-arginine C-reactive protein motor ability |
| url | http://www.mdpi.com/2072-6651/10/10/403 |
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