The effect of β-cyclodextrin and pH on bifonazole hydrosolubility
The equlibria of bifonazole in saturated water solution within the pH range 4 to 10 [I = 0.1 mol/dm3 (NaCl); 25 ºC] were studied spectrophotometrically. Based on the equlibrium constants determined in a heterogeneous system, the acidity constant (pKa = 5.72) and solubility in water (S=10-5.79+10-(pH...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2004-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2004/0352-51390403225P.pdf |
| _version_ | 1818864707125116928 |
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| author | Popović Gordana V. Čakar Mira M. |
| author_facet | Popović Gordana V. Čakar Mira M. |
| author_sort | Popović Gordana V. |
| collection | DOAJ |
| description | The equlibria of bifonazole in saturated water solution within the pH range 4 to 10 [I = 0.1 mol/dm3 (NaCl); 25 ºC] were studied spectrophotometrically. Based on the equlibrium constants determined in a heterogeneous system, the acidity constant (pKa = 5.72) and solubility in water (S=10-5.79+10-(pH + 0.07))were calculated. The influence of β-cyclodextrin on bifonazole solubility was examined in the presence of 10-3 and 10-4 mol/dm3 β-cyclodextrin. At pH values over 8, bifonazole solubility was two- and 13-fold increased in the presence of 10-4 and 10-3 mol/dm3 β-cyclodextrin respectively, compared to its solubility in water. The ratio of bifonazole solubility in the presence of β-cyclodextrin and that in water decreased in parallel to the increase of acidity. |
| first_indexed | 2024-12-19T10:35:56Z |
| format | Article |
| id | doaj.art-1e75ba7dfbde440b93a04ada425e8168 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-12-19T10:35:56Z |
| publishDate | 2004-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-1e75ba7dfbde440b93a04ada425e81682022-12-21T20:25:37ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212004-01-0169322523110.2298/JSC0403225P0352-51390403225PThe effect of β-cyclodextrin and pH on bifonazole hydrosolubilityPopović Gordana V.0Čakar Mira M.1Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia and MontenegroFaculty of Pharmacy, University of Belgrade, Belgrade, Serbia and MontenegroThe equlibria of bifonazole in saturated water solution within the pH range 4 to 10 [I = 0.1 mol/dm3 (NaCl); 25 ºC] were studied spectrophotometrically. Based on the equlibrium constants determined in a heterogeneous system, the acidity constant (pKa = 5.72) and solubility in water (S=10-5.79+10-(pH + 0.07))were calculated. The influence of β-cyclodextrin on bifonazole solubility was examined in the presence of 10-3 and 10-4 mol/dm3 β-cyclodextrin. At pH values over 8, bifonazole solubility was two- and 13-fold increased in the presence of 10-4 and 10-3 mol/dm3 β-cyclodextrin respectively, compared to its solubility in water. The ratio of bifonazole solubility in the presence of β-cyclodextrin and that in water decreased in parallel to the increase of acidity.http://www.doiserbia.nb.rs/img/doi/0352-5139/2004/0352-51390403225P.pdfbifonazoleacidity constantsolubilityβ-cyclodextrin |
| spellingShingle | Popović Gordana V. Čakar Mira M. The effect of β-cyclodextrin and pH on bifonazole hydrosolubility Journal of the Serbian Chemical Society bifonazole acidity constant solubility β-cyclodextrin |
| title | The effect of β-cyclodextrin and pH on bifonazole hydrosolubility |
| title_full | The effect of β-cyclodextrin and pH on bifonazole hydrosolubility |
| title_fullStr | The effect of β-cyclodextrin and pH on bifonazole hydrosolubility |
| title_full_unstemmed | The effect of β-cyclodextrin and pH on bifonazole hydrosolubility |
| title_short | The effect of β-cyclodextrin and pH on bifonazole hydrosolubility |
| title_sort | effect of β cyclodextrin and ph on bifonazole hydrosolubility |
| topic | bifonazole acidity constant solubility β-cyclodextrin |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2004/0352-51390403225P.pdf |
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