the Immunohistochemical Study of Stathmin-1 as A Prognostic factor In Non-small cell lung carcinoma
Background Stathmin1 (also known as metablastin) is a major microtubule-depolymerizing protein that involved in cell cycle progression and cell motility. Stathmin1 has been found to be up-regulated in some cancers and correlated with cell differentiation and proliferation. Stathmin1 is a m...
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College of Medicine University of Baghdad
2023-01-01
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| Series: | مجلة كلية الطب |
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| Online Access: | https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1948 |
| _version_ | 1797368081707696128 |
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| author | Nadhema Bahaa Hussein Wetwet Hadeel Abdulelah Karbel KERBEL Ali Salih Baay Baay Muhammed Whaeeb Salman Al-Obaidy |
| author_facet | Nadhema Bahaa Hussein Wetwet Hadeel Abdulelah Karbel KERBEL Ali Salih Baay Baay Muhammed Whaeeb Salman Al-Obaidy |
| author_sort | Nadhema Bahaa Hussein Wetwet |
| collection | DOAJ |
| description |
Background
Stathmin1 (also known as metablastin) is a major microtubule-depolymerizing protein that involved in cell cycle progression and cell motility.
Stathmin1 has been found to be up-regulated in some cancers and correlated with cell differentiation and proliferation.
Stathmin1 is a major cytosolic phosphoprotein that regulates microtubule dynamics and is associated with malignant phenotypes in various cancers, including non-small cell lung cancer.
Objective
To evaluate the role of Immunohistochemical expression of stathmin1 in non-small lung carcinoma and its correlation to different prognostic factors or parameters.
Materials and methods
This retrospective study carried on formalin fixed paraffin embedded surgical specimens of lung tumors Applying the Immunohistochemical techniques by using the primary antibodies to stathmin1, statistical analysis done and assessment of correlation with different clinical and pathological parameters measured.
Results
Fifty cases of Non-small lung carcinomas that 42% adenocarcinoma,44% squamous cell carcinoma 10% adenosequamous and 4% non-small lung carcinoma 84 % were Stathmin-1 positive.
No significant correlation between Stathmin-1 expression with age and gender of patients but Stathmin-1 expression were correlated with parameters including type and grade of tumor.
High expression was noted in poorly differentiated tumors.
Conclusions
Measurement of stathmin1 level may be a beneficial prognostic biomarker for non-small lung tumors especially those of poorly differentiated tumors
Stathmin1 expression in non-small cell lung carcinoma significantly correlated with poor tumor differentiation and could be considered as independent prognostic factor.
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| first_indexed | 2024-03-08T17:26:20Z |
| format | Article |
| id | doaj.art-1e75cf6d57c34b03bda9d247451e31db |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:26:20Z |
| publishDate | 2023-01-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-1e75cf6d57c34b03bda9d247451e31db2024-01-02T18:21:57ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572023-01-0164410.32007/jfacmedbagdad.6441948the Immunohistochemical Study of Stathmin-1 as A Prognostic factor In Non-small cell lung carcinomaNadhema Bahaa Hussein Wetwet0Hadeel Abdulelah Karbel KERBEL1Ali Salih Baay Baay2Muhammed Whaeeb Salman Al-Obaidy3Specialist in Clinical Pathology Professor of Clinical Pathology, Medical College of Hammurabi- University of Babylon.Professor of Respiratory Medicine, Medical College of Hammurabi- University of Babylon. Department of Medicine, College of Medicine – University of Baghdad Background Stathmin1 (also known as metablastin) is a major microtubule-depolymerizing protein that involved in cell cycle progression and cell motility. Stathmin1 has been found to be up-regulated in some cancers and correlated with cell differentiation and proliferation. Stathmin1 is a major cytosolic phosphoprotein that regulates microtubule dynamics and is associated with malignant phenotypes in various cancers, including non-small cell lung cancer. Objective To evaluate the role of Immunohistochemical expression of stathmin1 in non-small lung carcinoma and its correlation to different prognostic factors or parameters. Materials and methods This retrospective study carried on formalin fixed paraffin embedded surgical specimens of lung tumors Applying the Immunohistochemical techniques by using the primary antibodies to stathmin1, statistical analysis done and assessment of correlation with different clinical and pathological parameters measured. Results Fifty cases of Non-small lung carcinomas that 42% adenocarcinoma,44% squamous cell carcinoma 10% adenosequamous and 4% non-small lung carcinoma 84 % were Stathmin-1 positive. No significant correlation between Stathmin-1 expression with age and gender of patients but Stathmin-1 expression were correlated with parameters including type and grade of tumor. High expression was noted in poorly differentiated tumors. Conclusions Measurement of stathmin1 level may be a beneficial prognostic biomarker for non-small lung tumors especially those of poorly differentiated tumors Stathmin1 expression in non-small cell lung carcinoma significantly correlated with poor tumor differentiation and could be considered as independent prognostic factor. https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1948Stathmin-1, Lung Cancer. |
| spellingShingle | Nadhema Bahaa Hussein Wetwet Hadeel Abdulelah Karbel KERBEL Ali Salih Baay Baay Muhammed Whaeeb Salman Al-Obaidy the Immunohistochemical Study of Stathmin-1 as A Prognostic factor In Non-small cell lung carcinoma مجلة كلية الطب Stathmin-1, Lung Cancer. |
| title | the Immunohistochemical Study of Stathmin-1 as A Prognostic factor In Non-small cell lung carcinoma |
| title_full | the Immunohistochemical Study of Stathmin-1 as A Prognostic factor In Non-small cell lung carcinoma |
| title_fullStr | the Immunohistochemical Study of Stathmin-1 as A Prognostic factor In Non-small cell lung carcinoma |
| title_full_unstemmed | the Immunohistochemical Study of Stathmin-1 as A Prognostic factor In Non-small cell lung carcinoma |
| title_short | the Immunohistochemical Study of Stathmin-1 as A Prognostic factor In Non-small cell lung carcinoma |
| title_sort | immunohistochemical study of stathmin 1 as a prognostic factor in non small cell lung carcinoma |
| topic | Stathmin-1, Lung Cancer. |
| url | https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1948 |
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