Multiple breath washout testing in adults with pulmonary disease and healthy controls – can fewer measurements eventually be more?
Abstract Background Multiple breath washout (MBW) became a valuable research tool assessing ventilation heterogeneity. However, routine clinical application still faces several challenges. Deriving MBW parameters from three technically acceptable measurements according to current recommendations pro...
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| Format: | Article |
| Language: | English |
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BMC
2017-12-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12890-017-0543-y |
| _version_ | 1819102843892662272 |
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| author | Frederik Trinkmann Johannes Götzmann Daniel Saur Michele Schroeter Katharina Roth Ksenija Stach Martin Borggrefe Joachim Saur Ibrahim Akin Julia D. Michels |
| author_facet | Frederik Trinkmann Johannes Götzmann Daniel Saur Michele Schroeter Katharina Roth Ksenija Stach Martin Borggrefe Joachim Saur Ibrahim Akin Julia D. Michels |
| author_sort | Frederik Trinkmann |
| collection | DOAJ |
| description | Abstract Background Multiple breath washout (MBW) became a valuable research tool assessing ventilation heterogeneity. However, routine clinical application still faces several challenges. Deriving MBW parameters from three technically acceptable measurements according to current recommendations prolongs test times. We therefore aimed to evaluate reporting only duplicate measurements in healthy adults and pulmonary disease. Methods One hundred and fifty-three subjects prospectively underwent conventional lung function testing and closed-circuit SF6-MBW. Three technically acceptable MBW-measurements were obtained in 103 subjects. Results Lung clearance index (LCI) differed significantly among 19 controls (7.4 ± 0.8), 19 patients with sarcoidosis (8.1 ± 1.2), 32 with bronchial asthma (9.2 ± 1.9) and 33 with COPD (10.8 ± 2.2, p < 0.001). Within-test repeatability was high (coefficient of variation between 2.5% in controls and 3.6% in COPD) and remained unchanged when only including the first two measurements. Likewise, LCI remained stable with mean absolute changes ranging from 0.9 ± 0.8% in controls to 1.5 ± 0.9% in COPD (p = 0.1). Mean test time reduction differed significantly between groups reaching 200 s in COPD (p = 0.01). Conclusions Duplicate SF6-MBW-measurements are sufficient in adult patients with pulmonary disease and healthy controls. LCI values and intra-test repeatability are not affected reducing total test time statistically significant. Our findings have the potential to further facilitate application of MBW in research and clinical routine. Trial registration NCT03176745 , June 2, 2017 retrospectively registered. |
| first_indexed | 2024-12-22T01:41:01Z |
| format | Article |
| id | doaj.art-1e76acf0b2be41aab0fd222706c3fe18 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-22T01:41:01Z |
| publishDate | 2017-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-1e76acf0b2be41aab0fd222706c3fe182022-12-21T18:43:13ZengBMCBMC Pulmonary Medicine1471-24662017-12-011711810.1186/s12890-017-0543-yMultiple breath washout testing in adults with pulmonary disease and healthy controls – can fewer measurements eventually be more?Frederik Trinkmann0Johannes Götzmann1Daniel Saur2Michele Schroeter3Katharina Roth4Ksenija Stach5Martin Borggrefe6Joachim Saur7Ibrahim Akin8Julia D. Michels91st Department of Medicine (Cardiology, Angiology, Pulmonary and Intensive Care), University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University1st Department of Medicine (Cardiology, Angiology, Pulmonary and Intensive Care), University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University1st Department of Medicine (Cardiology, Angiology, Pulmonary and Intensive Care), University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University1st Department of Medicine (Cardiology, Angiology, Pulmonary and Intensive Care), University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University1st Department of Medicine (Cardiology, Angiology, Pulmonary and Intensive Care), University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University1st Department of Medicine (Cardiology, Angiology, Pulmonary and Intensive Care), University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University1st Department of Medicine (Cardiology, Angiology, Pulmonary and Intensive Care), University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University1st Department of Medicine (Cardiology, Angiology, Pulmonary and Intensive Care), University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University1st Department of Medicine (Cardiology, Angiology, Pulmonary and Intensive Care), University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University1st Department of Medicine (Cardiology, Angiology, Pulmonary and Intensive Care), University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg UniversityAbstract Background Multiple breath washout (MBW) became a valuable research tool assessing ventilation heterogeneity. However, routine clinical application still faces several challenges. Deriving MBW parameters from three technically acceptable measurements according to current recommendations prolongs test times. We therefore aimed to evaluate reporting only duplicate measurements in healthy adults and pulmonary disease. Methods One hundred and fifty-three subjects prospectively underwent conventional lung function testing and closed-circuit SF6-MBW. Three technically acceptable MBW-measurements were obtained in 103 subjects. Results Lung clearance index (LCI) differed significantly among 19 controls (7.4 ± 0.8), 19 patients with sarcoidosis (8.1 ± 1.2), 32 with bronchial asthma (9.2 ± 1.9) and 33 with COPD (10.8 ± 2.2, p < 0.001). Within-test repeatability was high (coefficient of variation between 2.5% in controls and 3.6% in COPD) and remained unchanged when only including the first two measurements. Likewise, LCI remained stable with mean absolute changes ranging from 0.9 ± 0.8% in controls to 1.5 ± 0.9% in COPD (p = 0.1). Mean test time reduction differed significantly between groups reaching 200 s in COPD (p = 0.01). Conclusions Duplicate SF6-MBW-measurements are sufficient in adult patients with pulmonary disease and healthy controls. LCI values and intra-test repeatability are not affected reducing total test time statistically significant. Our findings have the potential to further facilitate application of MBW in research and clinical routine. Trial registration NCT03176745 , June 2, 2017 retrospectively registered.http://link.springer.com/article/10.1186/s12890-017-0543-yMultiple breath washoutLung clearance indexDuplicate measurementsPulmonary diseaseAdults |
| spellingShingle | Frederik Trinkmann Johannes Götzmann Daniel Saur Michele Schroeter Katharina Roth Ksenija Stach Martin Borggrefe Joachim Saur Ibrahim Akin Julia D. Michels Multiple breath washout testing in adults with pulmonary disease and healthy controls – can fewer measurements eventually be more? BMC Pulmonary Medicine Multiple breath washout Lung clearance index Duplicate measurements Pulmonary disease Adults |
| title | Multiple breath washout testing in adults with pulmonary disease and healthy controls – can fewer measurements eventually be more? |
| title_full | Multiple breath washout testing in adults with pulmonary disease and healthy controls – can fewer measurements eventually be more? |
| title_fullStr | Multiple breath washout testing in adults with pulmonary disease and healthy controls – can fewer measurements eventually be more? |
| title_full_unstemmed | Multiple breath washout testing in adults with pulmonary disease and healthy controls – can fewer measurements eventually be more? |
| title_short | Multiple breath washout testing in adults with pulmonary disease and healthy controls – can fewer measurements eventually be more? |
| title_sort | multiple breath washout testing in adults with pulmonary disease and healthy controls can fewer measurements eventually be more |
| topic | Multiple breath washout Lung clearance index Duplicate measurements Pulmonary disease Adults |
| url | http://link.springer.com/article/10.1186/s12890-017-0543-y |
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