Evaluating the Effect of Tideglusib-Loaded Bioactive Glass Nanoparticles as a Potential Dentine Regenerative Material
Dental pulp treatment is the least intrusive procedure currently available for preserving the vitality of the pulp. Several studies are underway to improve the bioactivity of pulp capping materials. Tideglusib isa potent anti-inflammatory, antioxidant, and a regenerative drug developed against Alzhe...
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MDPI AG
2022-06-01
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| author | Akhil C. Rao K. Vijay Venkatesh Vidyashree Nandini Dhanasekaran Sihivahanan Ahmed Alamoudi Hammam Ahmed Bahammam Sarah Ahmed Bahammam Bassam Zidane Maha A. Bahammam Hitesh Chohan Nassreen H. Albar Pradeep Kumar Yadalam Shankargouda Patil |
| author_facet | Akhil C. Rao K. Vijay Venkatesh Vidyashree Nandini Dhanasekaran Sihivahanan Ahmed Alamoudi Hammam Ahmed Bahammam Sarah Ahmed Bahammam Bassam Zidane Maha A. Bahammam Hitesh Chohan Nassreen H. Albar Pradeep Kumar Yadalam Shankargouda Patil |
| author_sort | Akhil C. Rao |
| collection | DOAJ |
| description | Dental pulp treatment is the least intrusive procedure currently available for preserving the vitality of the pulp. Several studies are underway to improve the bioactivity of pulp capping materials. Tideglusib isa potent anti-inflammatory, antioxidant, and a regenerative drug developed against Alzheimer’s disease and has been shown to be effective in the treatment of dental cavities. However, its bioactive properties encapsulated within the nanoparticles as a component of pulp capping material are largely unknown. In this study, tideglusib-loaded bioactive glass nanoparticles were synthesized (tideglusib-BgNPs) and mixed at various concentrations into the calcium silicate cement to testits physiomechanical and bioactivitiescompared with biodentine (control). The calcium silicate cement with 10wgt% tideglusib-BgNPs showed comparable physiomechanical properties to that of biodentine. Additionally, the assessment of cytotoxicity and bioactivity (cell proliferation, wound healing, and cell migration assays) showed increased bioactivity in terms of better wound healing, increased proliferation, and better migration of human dental pulp stem cells than biodentine. These findings suggest new opportunities to use tideglusib-BgNPs in pulp therapy. |
| first_indexed | 2024-03-09T12:47:37Z |
| format | Article |
| id | doaj.art-1e77b70fa181462c90b1032ab4006488 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-09T12:47:37Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-1e77b70fa181462c90b1032ab40064882023-11-30T22:09:48ZengMDPI AGMaterials1996-19442022-06-011513456710.3390/ma15134567Evaluating the Effect of Tideglusib-Loaded Bioactive Glass Nanoparticles as a Potential Dentine Regenerative MaterialAkhil C. Rao0K. Vijay Venkatesh1Vidyashree Nandini2Dhanasekaran Sihivahanan3Ahmed Alamoudi4Hammam Ahmed Bahammam5Sarah Ahmed Bahammam6Bassam Zidane7Maha A. Bahammam8Hitesh Chohan9Nassreen H. Albar10Pradeep Kumar Yadalam11Shankargouda Patil12Department of Conservative Dentistry and Endodontics, SRM Dental College and Hospital, Kattankulathur, Kanchipuram, Chennai 603203, IndiaDepartment of Conservative Dentistry and Endodontics, SRM Dental College and Hospital, Kattankulathur, Kanchipuram, Chennai 603203, IndiaDepartment of Prosthodontics and Implantology, SRM Dental College and Hospital, Kattankulathur, Kanchipuram, Chennai 603203, IndiaDepartment of Conservative Dentistry and Endodontics, SRM Dental College and Hospital, Kattankulathur, Kanchipuram, Chennai 603203, IndiaOral Biology Department, Faculty of Dentistry, King Abdulaziz University, Jeddah 80209, Saudi ArabiaDepartment of Pediatric Dentistry, College of Dentistry, King Abdulaziz University, Jeddah 80209, Saudi ArabiaDepartment of Pediatric Dentistry and Orthodontics, College of Dentistry, Taibah University, Medina 42353, Saudi ArabiaRestorative Dentistry Department, Faculty of Dentistry, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Periodontology, Faculty of Dentistry, King Abdulaziz University, Jeddah 80209, Saudi ArabiaDepartment of Restorative Dental Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi ArabiaDepartment of Restorative Dental Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi ArabiaDepartment of Periodontics, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Saveetha University, Chennai 602117, IndiaDepartment of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan 45142, Saudi ArabiaDental pulp treatment is the least intrusive procedure currently available for preserving the vitality of the pulp. Several studies are underway to improve the bioactivity of pulp capping materials. Tideglusib isa potent anti-inflammatory, antioxidant, and a regenerative drug developed against Alzheimer’s disease and has been shown to be effective in the treatment of dental cavities. However, its bioactive properties encapsulated within the nanoparticles as a component of pulp capping material are largely unknown. In this study, tideglusib-loaded bioactive glass nanoparticles were synthesized (tideglusib-BgNPs) and mixed at various concentrations into the calcium silicate cement to testits physiomechanical and bioactivitiescompared with biodentine (control). The calcium silicate cement with 10wgt% tideglusib-BgNPs showed comparable physiomechanical properties to that of biodentine. Additionally, the assessment of cytotoxicity and bioactivity (cell proliferation, wound healing, and cell migration assays) showed increased bioactivity in terms of better wound healing, increased proliferation, and better migration of human dental pulp stem cells than biodentine. These findings suggest new opportunities to use tideglusib-BgNPs in pulp therapy.https://www.mdpi.com/1996-1944/15/13/4567tideglusib-BgNPsdentine regenerationtricalcium silicate-based cement |
| spellingShingle | Akhil C. Rao K. Vijay Venkatesh Vidyashree Nandini Dhanasekaran Sihivahanan Ahmed Alamoudi Hammam Ahmed Bahammam Sarah Ahmed Bahammam Bassam Zidane Maha A. Bahammam Hitesh Chohan Nassreen H. Albar Pradeep Kumar Yadalam Shankargouda Patil Evaluating the Effect of Tideglusib-Loaded Bioactive Glass Nanoparticles as a Potential Dentine Regenerative Material Materials tideglusib-BgNPs dentine regeneration tricalcium silicate-based cement |
| title | Evaluating the Effect of Tideglusib-Loaded Bioactive Glass Nanoparticles as a Potential Dentine Regenerative Material |
| title_full | Evaluating the Effect of Tideglusib-Loaded Bioactive Glass Nanoparticles as a Potential Dentine Regenerative Material |
| title_fullStr | Evaluating the Effect of Tideglusib-Loaded Bioactive Glass Nanoparticles as a Potential Dentine Regenerative Material |
| title_full_unstemmed | Evaluating the Effect of Tideglusib-Loaded Bioactive Glass Nanoparticles as a Potential Dentine Regenerative Material |
| title_short | Evaluating the Effect of Tideglusib-Loaded Bioactive Glass Nanoparticles as a Potential Dentine Regenerative Material |
| title_sort | evaluating the effect of tideglusib loaded bioactive glass nanoparticles as a potential dentine regenerative material |
| topic | tideglusib-BgNPs dentine regeneration tricalcium silicate-based cement |
| url | https://www.mdpi.com/1996-1944/15/13/4567 |
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