Long-term intake of Lilium lancifolium mitigated osteoarthritic effects by suppressing inflammatory cytokines in a dog model
Background and Aim: Osteoarthritis (OA) is a chronic, painful, degenerative inflammatory disease of the synovial joints. Regular use of nonsteroidal anti-inflammatory drugs to decrease OA pain can have severe side effects, such as gastric irritation, ulcers, and heart problems. Natural products are...
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| Format: | Article |
| Language: | English |
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Veterinary World
2022-08-01
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| Series: | Veterinary World |
| Subjects: | |
| Online Access: | http://www.veterinaryworld.org/Vol.15/August-2022/14.pdf |
| _version_ | 1798037166053392384 |
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| author | Jeong-Hwi Cho Yang-Gyu Park Jinyoung Choi Gareeballah Osman Adam Eun-Myeong Ju Ho Park Hong-Geun Oh |
| author_facet | Jeong-Hwi Cho Yang-Gyu Park Jinyoung Choi Gareeballah Osman Adam Eun-Myeong Ju Ho Park Hong-Geun Oh |
| author_sort | Jeong-Hwi Cho |
| collection | DOAJ |
| description | Background and Aim: Osteoarthritis (OA) is a chronic, painful, degenerative inflammatory disease of the synovial joints. Regular use of nonsteroidal anti-inflammatory drugs to decrease OA pain can have severe side effects, such as gastric irritation, ulcers, and heart problems. Natural products are extensively used to minimize OA-associated pain and inflammatory reactions. Lilium lancifolium is commonly used to alleviate several diseases through its anti-inflammatory effects. This study examined the impact of L. lancifolium extract on alleviating pain and inflammation associated with articular cartilage damage.
Materials and Methods: Hydro-ethanol extracts of the L. lancifolium bulb were used. The experimental animals (adult beagle dogs) were divided into four groups: sham, which received neither treatment nor surgery; placebo, which received an empty gelatin capsule; glucosamine, which received glutamine (60 mg/kg); and L. lancifolium, which received an L. lancifolium extract-filled (60 mg/kg) gelatin capsule for 8 weeks. OA was induced by an expert orthopedic surgeon in 2-year-old dogs through resection of cranial cruciate ligament and lateral collateral ligament. Inflammatory cytokines, enzymes, lameness score, radiology, and histological changes were assessed.
Results: Our experiments showed that long-term oral therapy with L. lancifolium alleviated inflammation and increased histological damage. L. lancifolium treatment effectively reduced cytokines, such as interleukin-6, metalloproteinase-9, leukotriene-4, prostaglandin, and cyclo-oxygenase in dogs with OA, suggesting the potential to minimize inflammatory reactions in OA. L. lancifolium showed anti-inflammatory qualities in dogs with OA. This effect was comparable with that of glucosamine OA treatment.
Conclusion: L. lancifolium supplementation represents a possible therapeutic and management option in this model of OA. |
| first_indexed | 2024-04-11T21:22:53Z |
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| id | doaj.art-1e7e8333026f4845b231d140c78e383a |
| institution | Directory Open Access Journal |
| issn | 0972-8988 2231-0916 |
| language | English |
| last_indexed | 2024-04-11T21:22:53Z |
| publishDate | 2022-08-01 |
| publisher | Veterinary World |
| record_format | Article |
| series | Veterinary World |
| spelling | doaj.art-1e7e8333026f4845b231d140c78e383a2022-12-22T04:02:34ZengVeterinary WorldVeterinary World0972-89882231-09162022-08-011582012202010.14202/vetworld.2022.2012-2020Long-term intake of Lilium lancifolium mitigated osteoarthritic effects by suppressing inflammatory cytokines in a dog modelJeong-Hwi Cho0https://orcid.org/0000-0001-5270-4438Yang-Gyu Park1https://orcid.org/0000-0003-3996-3202Jinyoung Choi2https://orcid.org/0000-0002-4287-5302Gareeballah Osman Adam3https://orcid.org/0000-0002-8650-8117Eun-Myeong Ju4https://orcid.org/0000-0001-6909-6408Ho Park5https://orcid.org/0000-0003-2552-8023Hong-Geun Oh6https://orcid.org/0000-0003-4712-8055R&D Division, HUVET Co. Ltd., Iksan-si 54531, Republic of Korea.R&D Division, HUVET Co. Ltd., Iksan-si 54531, Republic of Korea.R&D Division, HUVET Co. Ltd., Iksan-si 54531, Republic of Korea.R&D Division, HUVET Co. Ltd., Iksan-si 54531, Republic of Korea; Department of Veterinary Medicine and Surgery College of Veterinary Medicine, Sudan University of Science and Technology, Hilat Kuku, Khartoum 11311, Sudan.R&D Division, HUVET Co. Ltd., Iksan-si 54531, Republic of Korea.Department of Clinical Laboratory Science, Wonkwang Health Science University, Iksan 54538, Republic of Korea.R&D Division, HUVET Co. Ltd., Iksan-si 54531, Republic of Korea.Background and Aim: Osteoarthritis (OA) is a chronic, painful, degenerative inflammatory disease of the synovial joints. Regular use of nonsteroidal anti-inflammatory drugs to decrease OA pain can have severe side effects, such as gastric irritation, ulcers, and heart problems. Natural products are extensively used to minimize OA-associated pain and inflammatory reactions. Lilium lancifolium is commonly used to alleviate several diseases through its anti-inflammatory effects. This study examined the impact of L. lancifolium extract on alleviating pain and inflammation associated with articular cartilage damage. Materials and Methods: Hydro-ethanol extracts of the L. lancifolium bulb were used. The experimental animals (adult beagle dogs) were divided into four groups: sham, which received neither treatment nor surgery; placebo, which received an empty gelatin capsule; glucosamine, which received glutamine (60 mg/kg); and L. lancifolium, which received an L. lancifolium extract-filled (60 mg/kg) gelatin capsule for 8 weeks. OA was induced by an expert orthopedic surgeon in 2-year-old dogs through resection of cranial cruciate ligament and lateral collateral ligament. Inflammatory cytokines, enzymes, lameness score, radiology, and histological changes were assessed. Results: Our experiments showed that long-term oral therapy with L. lancifolium alleviated inflammation and increased histological damage. L. lancifolium treatment effectively reduced cytokines, such as interleukin-6, metalloproteinase-9, leukotriene-4, prostaglandin, and cyclo-oxygenase in dogs with OA, suggesting the potential to minimize inflammatory reactions in OA. L. lancifolium showed anti-inflammatory qualities in dogs with OA. This effect was comparable with that of glucosamine OA treatment. Conclusion: L. lancifolium supplementation represents a possible therapeutic and management option in this model of OA.http://www.veterinaryworld.org/Vol.15/August-2022/14.pdfarticular cartilageinflammationjoint painlilium lancifoliummmp-9osteoarthritis |
| spellingShingle | Jeong-Hwi Cho Yang-Gyu Park Jinyoung Choi Gareeballah Osman Adam Eun-Myeong Ju Ho Park Hong-Geun Oh Long-term intake of Lilium lancifolium mitigated osteoarthritic effects by suppressing inflammatory cytokines in a dog model Veterinary World articular cartilage inflammation joint pain lilium lancifolium mmp-9 osteoarthritis |
| title | Long-term intake of Lilium lancifolium mitigated osteoarthritic effects by suppressing inflammatory cytokines in a dog model |
| title_full | Long-term intake of Lilium lancifolium mitigated osteoarthritic effects by suppressing inflammatory cytokines in a dog model |
| title_fullStr | Long-term intake of Lilium lancifolium mitigated osteoarthritic effects by suppressing inflammatory cytokines in a dog model |
| title_full_unstemmed | Long-term intake of Lilium lancifolium mitigated osteoarthritic effects by suppressing inflammatory cytokines in a dog model |
| title_short | Long-term intake of Lilium lancifolium mitigated osteoarthritic effects by suppressing inflammatory cytokines in a dog model |
| title_sort | long term intake of lilium lancifolium mitigated osteoarthritic effects by suppressing inflammatory cytokines in a dog model |
| topic | articular cartilage inflammation joint pain lilium lancifolium mmp-9 osteoarthritis |
| url | http://www.veterinaryworld.org/Vol.15/August-2022/14.pdf |
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