Engaging plasticity: Differentiation therapy in solid tumors
Cancer is a systemic heterogeneous disease that can undergo several rounds of latency and activation. Tumor progression evolves by increasing diversity, adaptation to signals from the microenvironment and escape mechanisms from therapy. These dynamic processes indicate necessity for cell plasticity....
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.944773/full |
| _version_ | 1811321709739900928 |
|---|---|
| author | Neta Bar-Hai Neta Bar-Hai Dana Ishay-Ronen Dana Ishay-Ronen |
| author_facet | Neta Bar-Hai Neta Bar-Hai Dana Ishay-Ronen Dana Ishay-Ronen |
| author_sort | Neta Bar-Hai |
| collection | DOAJ |
| description | Cancer is a systemic heterogeneous disease that can undergo several rounds of latency and activation. Tumor progression evolves by increasing diversity, adaptation to signals from the microenvironment and escape mechanisms from therapy. These dynamic processes indicate necessity for cell plasticity. Epithelial-mesenchymal transition (EMT) plays a major role in facilitating cell plasticity in solid tumors by inducing dedifferentiation and cell type transitions. These two practices, plasticity and dedifferentiation enhance tumor heterogeneity creating a key challenge in cancer treatment. In this review we will explore cancer cell plasticity and elaborate treatment modalities that aspire to overcome such dynamic processes in solid tumors. We will further discuss the therapeutic potential of utilizing enhanced cell plasticity for differentiation therapy. |
| first_indexed | 2024-04-13T13:21:20Z |
| format | Article |
| id | doaj.art-1e8205f0c7294ce58e706f6552f55fcb |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T13:21:20Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-1e8205f0c7294ce58e706f6552f55fcb2022-12-22T02:45:17ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-08-011310.3389/fphar.2022.944773944773Engaging plasticity: Differentiation therapy in solid tumorsNeta Bar-Hai0Neta Bar-Hai1Dana Ishay-Ronen2Dana Ishay-Ronen3Cancer Research Center, Oncology Institute, Chaim Sheba Medical Center, Tel-Hashomer, IsraelAffiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelCancer Research Center, Oncology Institute, Chaim Sheba Medical Center, Tel-Hashomer, IsraelAffiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelCancer is a systemic heterogeneous disease that can undergo several rounds of latency and activation. Tumor progression evolves by increasing diversity, adaptation to signals from the microenvironment and escape mechanisms from therapy. These dynamic processes indicate necessity for cell plasticity. Epithelial-mesenchymal transition (EMT) plays a major role in facilitating cell plasticity in solid tumors by inducing dedifferentiation and cell type transitions. These two practices, plasticity and dedifferentiation enhance tumor heterogeneity creating a key challenge in cancer treatment. In this review we will explore cancer cell plasticity and elaborate treatment modalities that aspire to overcome such dynamic processes in solid tumors. We will further discuss the therapeutic potential of utilizing enhanced cell plasticity for differentiation therapy.https://www.frontiersin.org/articles/10.3389/fphar.2022.944773/fullcancer cell plasticityEMTdifferentiation therapytrans-differentiationTGFb signalingsolid tumors |
| spellingShingle | Neta Bar-Hai Neta Bar-Hai Dana Ishay-Ronen Dana Ishay-Ronen Engaging plasticity: Differentiation therapy in solid tumors Frontiers in Pharmacology cancer cell plasticity EMT differentiation therapy trans-differentiation TGFb signaling solid tumors |
| title | Engaging plasticity: Differentiation therapy in solid tumors |
| title_full | Engaging plasticity: Differentiation therapy in solid tumors |
| title_fullStr | Engaging plasticity: Differentiation therapy in solid tumors |
| title_full_unstemmed | Engaging plasticity: Differentiation therapy in solid tumors |
| title_short | Engaging plasticity: Differentiation therapy in solid tumors |
| title_sort | engaging plasticity differentiation therapy in solid tumors |
| topic | cancer cell plasticity EMT differentiation therapy trans-differentiation TGFb signaling solid tumors |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.944773/full |
| work_keys_str_mv | AT netabarhai engagingplasticitydifferentiationtherapyinsolidtumors AT netabarhai engagingplasticitydifferentiationtherapyinsolidtumors AT danaishayronen engagingplasticitydifferentiationtherapyinsolidtumors AT danaishayronen engagingplasticitydifferentiationtherapyinsolidtumors |