Insight on the cellular and molecular basis of blood vessel formation: A specific focus on tumor targets and therapy
Abstract The cellular and molecular switches that govern angiogenesis are considered therapeutic targets for several diseases like tumors and atherosclerosis. Thus, understanding the detailed molecular mechanisms underlying the formation of the new blood vessel is essential for developing novel ther...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-03-01
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| Series: | MedComm – Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mog2.22 |
| _version_ | 1827949854934958080 |
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| author | Nimish Mol Stephen Udayawara Rudresh Deepika Tehreem Maradagi Tatsuya Sugawara Takashi Hirata Ponesakki Ganesan |
| author_facet | Nimish Mol Stephen Udayawara Rudresh Deepika Tehreem Maradagi Tatsuya Sugawara Takashi Hirata Ponesakki Ganesan |
| author_sort | Nimish Mol Stephen |
| collection | DOAJ |
| description | Abstract The cellular and molecular switches that govern angiogenesis are considered therapeutic targets for several diseases like tumors and atherosclerosis. Thus, understanding the detailed molecular mechanisms underlying the formation of the new blood vessel is essential for developing novel therapeutic strategies. The formation of a new blood vessel (angiogenesis) is tightly regulated by balancing pro‐ and antiangiogenic molecules. Dysregulated angiogenesis contributes to the pathogenicity of several diseases, including tumors associated with uncontrolled vessel growth. Experimental and clinical studies emphasize that angiogenesis is a critical step for the transition of the tumor to a life‐threatening malignancy. In recent years, angiogenesis has been targeted as one of the primary therapeutic goals for treating tumors, and rapid progress has been made by modulating its molecular regulators. Hence, the mechanisms of how blood vessel formation occurs could provide molecular insight into future angiogenic therapy. This review summarizes briefly the molecular players of blood vessel formation comprising vasculogenesis and angiogenesis and their role in tumor progression alongside antiangiogenic therapy. |
| first_indexed | 2024-04-09T13:16:23Z |
| format | Article |
| id | doaj.art-1e82be825fc1491fb39eac0e226bbd01 |
| institution | Directory Open Access Journal |
| issn | 2769-6448 |
| language | English |
| last_indexed | 2024-04-09T13:16:23Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm – Oncology |
| spelling | doaj.art-1e82be825fc1491fb39eac0e226bbd012023-05-11T17:25:28ZengWileyMedComm – Oncology2769-64482023-03-0121n/an/a10.1002/mog2.22Insight on the cellular and molecular basis of blood vessel formation: A specific focus on tumor targets and therapyNimish Mol Stephen0Udayawara Rudresh Deepika1Tehreem Maradagi2Tatsuya Sugawara3Takashi Hirata4Ponesakki Ganesan5Department of Fish Processing Technology, Dr. MGR Fisheries College & Research Institute Tamil Nadu Dr J Jayalalithaa Fisheries University Ponneri Tamil Nadu IndiaDepartment of Molecular Nutrition CSIR‐Central Food Technological Research Institute (CFTRI) Mysuru Karnataka IndiaDepartment of Molecular Nutrition CSIR‐Central Food Technological Research Institute (CFTRI) Mysuru Karnataka IndiaDivision of Applied Biosciences, Graduate School of Agriculture Kyoto University Kyoto JapanFaculty of Rehabilitation Shijonawate Gakuen University Daito Osaka JapanDepartment of Molecular Nutrition CSIR‐Central Food Technological Research Institute (CFTRI) Mysuru Karnataka IndiaAbstract The cellular and molecular switches that govern angiogenesis are considered therapeutic targets for several diseases like tumors and atherosclerosis. Thus, understanding the detailed molecular mechanisms underlying the formation of the new blood vessel is essential for developing novel therapeutic strategies. The formation of a new blood vessel (angiogenesis) is tightly regulated by balancing pro‐ and antiangiogenic molecules. Dysregulated angiogenesis contributes to the pathogenicity of several diseases, including tumors associated with uncontrolled vessel growth. Experimental and clinical studies emphasize that angiogenesis is a critical step for the transition of the tumor to a life‐threatening malignancy. In recent years, angiogenesis has been targeted as one of the primary therapeutic goals for treating tumors, and rapid progress has been made by modulating its molecular regulators. Hence, the mechanisms of how blood vessel formation occurs could provide molecular insight into future angiogenic therapy. This review summarizes briefly the molecular players of blood vessel formation comprising vasculogenesis and angiogenesis and their role in tumor progression alongside antiangiogenic therapy.https://doi.org/10.1002/mog2.22angiogenesisangiogenic therapymolecular playerstumor angiogenesisvasculogenesis |
| spellingShingle | Nimish Mol Stephen Udayawara Rudresh Deepika Tehreem Maradagi Tatsuya Sugawara Takashi Hirata Ponesakki Ganesan Insight on the cellular and molecular basis of blood vessel formation: A specific focus on tumor targets and therapy MedComm – Oncology angiogenesis angiogenic therapy molecular players tumor angiogenesis vasculogenesis |
| title | Insight on the cellular and molecular basis of blood vessel formation: A specific focus on tumor targets and therapy |
| title_full | Insight on the cellular and molecular basis of blood vessel formation: A specific focus on tumor targets and therapy |
| title_fullStr | Insight on the cellular and molecular basis of blood vessel formation: A specific focus on tumor targets and therapy |
| title_full_unstemmed | Insight on the cellular and molecular basis of blood vessel formation: A specific focus on tumor targets and therapy |
| title_short | Insight on the cellular and molecular basis of blood vessel formation: A specific focus on tumor targets and therapy |
| title_sort | insight on the cellular and molecular basis of blood vessel formation a specific focus on tumor targets and therapy |
| topic | angiogenesis angiogenic therapy molecular players tumor angiogenesis vasculogenesis |
| url | https://doi.org/10.1002/mog2.22 |
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