Higher sclerostin is associated with pulmonary hypertension in pre-dialysis end-stage kidney disease patients: a cross-sectional prospective observational cohort study

Higher sclerostin is associated with pulmonary hypertension in pre-dialysis end-stage kidney disease patients: a cross-sectional prospective observational cohort study

Abstract Background Pulmonary hypertension (PH) is a complication of chronic kidney disease (CKD) that contributes to mortality. Sclerostin, a SOST gene product that reduces osteoblastic bone formation by inhibiting Wnt/β-catenin signaling, is involved in arterial stiffness and CKD-bone mineral dise...

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Bibliographic Details
Main Authors: Jonghyun Lee, Dong-Hyuk Cho, Hyeon-Jin Min, Young-Bin Son, Tae Bum Kim, Se Won Oh, Myung-Gyu Kim, Won Yong Cho, Sang-Kyung Jo, Jihyun Yang
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Pulmonary Medicine
Subjects:
Chronic kidney disease
End-stage kidney disease
Mortality
Pulmonary hypertension
Wnt signaling
Online Access:https://doi.org/10.1186/s12890-024-02871-8

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