Spontaneous remission of acute myeloid leukemia with NF1 alteration
Acute myeloid leukemia (AML) is defined by the presence of ≥ 20% myeloblasts in the blood or bone marrow. Spontaneous remission (SR) of AML is a rare event, with few cases described in the literature. SR is generally associated with recovery from an infectious or immunologic process, and more recent...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Leukemia Research Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048920300108 |
| _version_ | 1828497518307049472 |
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| author | Terrence Bradley Radames Adamo Zuquello Luis E. Aguirre, MD Nicholas Mackrides Jennifer Chapman Luisa Cimmino Amber Thomassen Justin Watts |
| author_facet | Terrence Bradley Radames Adamo Zuquello Luis E. Aguirre, MD Nicholas Mackrides Jennifer Chapman Luisa Cimmino Amber Thomassen Justin Watts |
| author_sort | Terrence Bradley |
| collection | DOAJ |
| description | Acute myeloid leukemia (AML) is defined by the presence of ≥ 20% myeloblasts in the blood or bone marrow. Spontaneous remission (SR) of AML is a rare event, with few cases described in the literature. SR is generally associated with recovery from an infectious or immunologic process, and more recently possibly with clonal hematopoiesis. We review the literature and assess the trends associated with SR, and report a new case of a 58-year-old man with a morphologic diagnosis of AML associated with a severe gastrointestinal (GI) tract infection. The patient had an NF1 variant that was previously unreported in AML as the only clonal abnormality. After treatment of the infection, the increased blast population subsided with no leukemia-directed therapy, and the patient has remained in a continuous, spontaneous complete remission for > 2 years. |
| first_indexed | 2024-12-11T12:48:37Z |
| format | Article |
| id | doaj.art-1e851e7d8f7f44e7b9422f932a598d0a |
| institution | Directory Open Access Journal |
| issn | 2213-0489 |
| language | English |
| last_indexed | 2024-12-11T12:48:37Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj.art-1e851e7d8f7f44e7b9422f932a598d0a2022-12-22T01:06:44ZengElsevierLeukemia Research Reports2213-04892020-01-0113100204Spontaneous remission of acute myeloid leukemia with NF1 alterationTerrence Bradley0Radames Adamo Zuquello1Luis E. Aguirre, MD2Nicholas Mackrides3Jennifer Chapman4Luisa Cimmino5Amber Thomassen6Justin Watts7University of Miami, Department of Medicine, Miami, FL, United States; Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, United StatesUniversity of Miami, Department of Medicine, Miami, FL, United StatesUniversity of Miami, Department of Medicine, Miami, FL, United StatesUniversity of Miami, Department of Pathology, Miami, FL, United StatesUniversity of Miami, Department of Pathology, Miami, FL, United StatesSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, United States; University of Miami, Deparment of Biochemistry and Molecular Biology, Miami, FL, United StatesSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, United StatesUniversity of Miami, Department of Medicine, Miami, FL, United States; Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, United States; Corresponding author.Acute myeloid leukemia (AML) is defined by the presence of ≥ 20% myeloblasts in the blood or bone marrow. Spontaneous remission (SR) of AML is a rare event, with few cases described in the literature. SR is generally associated with recovery from an infectious or immunologic process, and more recently possibly with clonal hematopoiesis. We review the literature and assess the trends associated with SR, and report a new case of a 58-year-old man with a morphologic diagnosis of AML associated with a severe gastrointestinal (GI) tract infection. The patient had an NF1 variant that was previously unreported in AML as the only clonal abnormality. After treatment of the infection, the increased blast population subsided with no leukemia-directed therapy, and the patient has remained in a continuous, spontaneous complete remission for > 2 years.http://www.sciencedirect.com/science/article/pii/S2213048920300108Acute myeloid leukemiaNF1 alterationClonal hematopoiesisSpontaneous remissionLeukemoid reaction |
| spellingShingle | Terrence Bradley Radames Adamo Zuquello Luis E. Aguirre, MD Nicholas Mackrides Jennifer Chapman Luisa Cimmino Amber Thomassen Justin Watts Spontaneous remission of acute myeloid leukemia with NF1 alteration Leukemia Research Reports Acute myeloid leukemia NF1 alteration Clonal hematopoiesis Spontaneous remission Leukemoid reaction |
| title | Spontaneous remission of acute myeloid leukemia with NF1 alteration |
| title_full | Spontaneous remission of acute myeloid leukemia with NF1 alteration |
| title_fullStr | Spontaneous remission of acute myeloid leukemia with NF1 alteration |
| title_full_unstemmed | Spontaneous remission of acute myeloid leukemia with NF1 alteration |
| title_short | Spontaneous remission of acute myeloid leukemia with NF1 alteration |
| title_sort | spontaneous remission of acute myeloid leukemia with nf1 alteration |
| topic | Acute myeloid leukemia NF1 alteration Clonal hematopoiesis Spontaneous remission Leukemoid reaction |
| url | http://www.sciencedirect.com/science/article/pii/S2213048920300108 |
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