Glial glucose fuels the neuronal pentose phosphate pathway for long-term memory
Summary: Brain function relies almost solely on glucose as an energy substrate. The main model of brain metabolism proposes that glucose is taken up and converted into lactate by astrocytes to fuel the energy-demanding neuronal activity underlying plasticity and memory. Whether direct neuronal gluco...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-08-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124721010585 |
| _version_ | 1819135834675216384 |
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| author | Eloïse de Tredern Yasmine Rabah Laure Pasquer Julia Minatchy Pierre-Yves Plaçais Thomas Preat |
| author_facet | Eloïse de Tredern Yasmine Rabah Laure Pasquer Julia Minatchy Pierre-Yves Plaçais Thomas Preat |
| author_sort | Eloïse de Tredern |
| collection | DOAJ |
| description | Summary: Brain function relies almost solely on glucose as an energy substrate. The main model of brain metabolism proposes that glucose is taken up and converted into lactate by astrocytes to fuel the energy-demanding neuronal activity underlying plasticity and memory. Whether direct neuronal glucose uptake is required for memory formation remains elusive. We uncover, in Drosophila, a mechanism of glucose shuttling to neurons from cortex glia, an exclusively perisomatic glial subtype, upon formation of olfactory long-term memory (LTM). In vivo imaging reveals that, downstream of cholinergic activation of cortex glia, autocrine insulin signaling increases glucose concentration in glia. Glucose is then transferred from glia to the neuronal somata in the olfactory memory center to fuel the pentose phosphate pathway and allow LTM formation. In contrast, our results indicate that the increase in neuronal glucose metabolism, although crucial for LTM formation, is not routed to glycolysis. |
| first_indexed | 2024-12-22T10:25:23Z |
| format | Article |
| id | doaj.art-1e86f296eb18470b84240d7d1290bf72 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-22T10:25:23Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-1e86f296eb18470b84240d7d1290bf722022-12-21T18:29:29ZengElsevierCell Reports2211-12472021-08-01368109620Glial glucose fuels the neuronal pentose phosphate pathway for long-term memoryEloïse de Tredern0Yasmine Rabah1Laure Pasquer2Julia Minatchy3Pierre-Yves Plaçais4Thomas Preat5Energy & Memory, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, 10 rue Vauquelin, 75005 Paris, FranceEnergy & Memory, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, 10 rue Vauquelin, 75005 Paris, FranceEnergy & Memory, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, 10 rue Vauquelin, 75005 Paris, FranceEnergy & Memory, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, 10 rue Vauquelin, 75005 Paris, FranceEnergy & Memory, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, 10 rue Vauquelin, 75005 Paris, France; Corresponding authorEnergy & Memory, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, 10 rue Vauquelin, 75005 Paris, France; Corresponding authorSummary: Brain function relies almost solely on glucose as an energy substrate. The main model of brain metabolism proposes that glucose is taken up and converted into lactate by astrocytes to fuel the energy-demanding neuronal activity underlying plasticity and memory. Whether direct neuronal glucose uptake is required for memory formation remains elusive. We uncover, in Drosophila, a mechanism of glucose shuttling to neurons from cortex glia, an exclusively perisomatic glial subtype, upon formation of olfactory long-term memory (LTM). In vivo imaging reveals that, downstream of cholinergic activation of cortex glia, autocrine insulin signaling increases glucose concentration in glia. Glucose is then transferred from glia to the neuronal somata in the olfactory memory center to fuel the pentose phosphate pathway and allow LTM formation. In contrast, our results indicate that the increase in neuronal glucose metabolism, although crucial for LTM formation, is not routed to glycolysis.http://www.sciencedirect.com/science/article/pii/S2211124721010585glialong-term memoryglucoseenergy metabolismpentose phosphate pathwayinsulin |
| spellingShingle | Eloïse de Tredern Yasmine Rabah Laure Pasquer Julia Minatchy Pierre-Yves Plaçais Thomas Preat Glial glucose fuels the neuronal pentose phosphate pathway for long-term memory Cell Reports glia long-term memory glucose energy metabolism pentose phosphate pathway insulin |
| title | Glial glucose fuels the neuronal pentose phosphate pathway for long-term memory |
| title_full | Glial glucose fuels the neuronal pentose phosphate pathway for long-term memory |
| title_fullStr | Glial glucose fuels the neuronal pentose phosphate pathway for long-term memory |
| title_full_unstemmed | Glial glucose fuels the neuronal pentose phosphate pathway for long-term memory |
| title_short | Glial glucose fuels the neuronal pentose phosphate pathway for long-term memory |
| title_sort | glial glucose fuels the neuronal pentose phosphate pathway for long term memory |
| topic | glia long-term memory glucose energy metabolism pentose phosphate pathway insulin |
| url | http://www.sciencedirect.com/science/article/pii/S2211124721010585 |
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