Effect of Pesticide Vinclozolin Toxicity Exposure on Cardiac Oxidative Stress and Myocardial Damage
(1) Background: Vinclozolin is a popular fungicide used in fruit, ornamental plants, and vegetable crops. It has recently been seen that prolonged exposure to VZN can cause human or animal health damage to various organs, but little is known to date about its cardiovascular effects. In this study, w...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/11/6/473 |
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| author | Alessio Filippo Peritore Gianluca Antonio Franco Francesco Molinari Alessia Arangia Livia Interdonato Ylenia Marino Salvatore Cuzzocrea Enrico Gugliandolo Domenico Britti Rosalia Crupi |
| author_facet | Alessio Filippo Peritore Gianluca Antonio Franco Francesco Molinari Alessia Arangia Livia Interdonato Ylenia Marino Salvatore Cuzzocrea Enrico Gugliandolo Domenico Britti Rosalia Crupi |
| author_sort | Alessio Filippo Peritore |
| collection | DOAJ |
| description | (1) Background: Vinclozolin is a popular fungicide used in fruit, ornamental plants, and vegetable crops. It has recently been seen that prolonged exposure to VZN can cause human or animal health damage to various organs, but little is known to date about its cardiovascular effects. In this study, we addressed the chronic effects of VZN on the myocardium and the enzymes involved in the cardiovascular function. (2) Methods: The animals were divided into four groups: group 1 served as the control, group 2 received 1 mg/kg of VZN by gavage, group 3 received 30 mg/kg of VZN by gavage, and group 4 received 100 mg/kg of VZN by gavage, for 30 days. (3) Results: Results showed that 100 mg/kg VZN markedly increased the plasma concentration of cardiac markers (CK-MB, cTnT, ANP, BNP). Moreover, compared to the control group, VZN treatment decreased the activity of SOD, CAT, and GPx, and downregulated the mRNA expression levels of Nrf2. Furthermore, collagen deposition was amplified owing to 100 mg/kg VZN cardiotoxicity. This harmful effect was confirmed by a histological study using hematoxylin and eosin (H&E) and Masson’s trichrome staining. (4) Conclusion: Overall, our results proved the cardiotoxicity caused by chronic exposure to VZN. |
| first_indexed | 2024-03-11T01:51:48Z |
| format | Article |
| id | doaj.art-1e8ba69d7b564b5ca3333fe08625f974 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-11T01:51:48Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-1e8ba69d7b564b5ca3333fe08625f9742023-11-18T12:54:06ZengMDPI AGToxics2305-63042023-05-0111647310.3390/toxics11060473Effect of Pesticide Vinclozolin Toxicity Exposure on Cardiac Oxidative Stress and Myocardial DamageAlessio Filippo Peritore0Gianluca Antonio Franco1Francesco Molinari2Alessia Arangia3Livia Interdonato4Ylenia Marino5Salvatore Cuzzocrea6Enrico Gugliandolo7Domenico Britti8Rosalia Crupi9Department of Veterinary Science, University of Messina, 98168 Messina, ItalyDepartment of Veterinary Science, University of Messina, 98168 Messina, ItalyDepartment of of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, 98166 Messina, ItalyDepartment of of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, 98166 Messina, ItalyDepartment of of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, 98166 Messina, ItalyDepartment of of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, 98166 Messina, ItalyDepartment of of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, 98166 Messina, ItalyDepartment of Veterinary Science, University of Messina, 98168 Messina, ItalyDepartment of Health Sciences, “Magna Græcia University” of Catanzaro, Campus Universitario “Salvatore Venuta” Viale Europa, 88100 Catanzaro, ItalyDepartment of Veterinary Science, University of Messina, 98168 Messina, Italy(1) Background: Vinclozolin is a popular fungicide used in fruit, ornamental plants, and vegetable crops. It has recently been seen that prolonged exposure to VZN can cause human or animal health damage to various organs, but little is known to date about its cardiovascular effects. In this study, we addressed the chronic effects of VZN on the myocardium and the enzymes involved in the cardiovascular function. (2) Methods: The animals were divided into four groups: group 1 served as the control, group 2 received 1 mg/kg of VZN by gavage, group 3 received 30 mg/kg of VZN by gavage, and group 4 received 100 mg/kg of VZN by gavage, for 30 days. (3) Results: Results showed that 100 mg/kg VZN markedly increased the plasma concentration of cardiac markers (CK-MB, cTnT, ANP, BNP). Moreover, compared to the control group, VZN treatment decreased the activity of SOD, CAT, and GPx, and downregulated the mRNA expression levels of Nrf2. Furthermore, collagen deposition was amplified owing to 100 mg/kg VZN cardiotoxicity. This harmful effect was confirmed by a histological study using hematoxylin and eosin (H&E) and Masson’s trichrome staining. (4) Conclusion: Overall, our results proved the cardiotoxicity caused by chronic exposure to VZN.https://www.mdpi.com/2305-6304/11/6/473pesticidescardiotoxicityoxidative stress |
| spellingShingle | Alessio Filippo Peritore Gianluca Antonio Franco Francesco Molinari Alessia Arangia Livia Interdonato Ylenia Marino Salvatore Cuzzocrea Enrico Gugliandolo Domenico Britti Rosalia Crupi Effect of Pesticide Vinclozolin Toxicity Exposure on Cardiac Oxidative Stress and Myocardial Damage Toxics pesticides cardiotoxicity oxidative stress |
| title | Effect of Pesticide Vinclozolin Toxicity Exposure on Cardiac Oxidative Stress and Myocardial Damage |
| title_full | Effect of Pesticide Vinclozolin Toxicity Exposure on Cardiac Oxidative Stress and Myocardial Damage |
| title_fullStr | Effect of Pesticide Vinclozolin Toxicity Exposure on Cardiac Oxidative Stress and Myocardial Damage |
| title_full_unstemmed | Effect of Pesticide Vinclozolin Toxicity Exposure on Cardiac Oxidative Stress and Myocardial Damage |
| title_short | Effect of Pesticide Vinclozolin Toxicity Exposure on Cardiac Oxidative Stress and Myocardial Damage |
| title_sort | effect of pesticide vinclozolin toxicity exposure on cardiac oxidative stress and myocardial damage |
| topic | pesticides cardiotoxicity oxidative stress |
| url | https://www.mdpi.com/2305-6304/11/6/473 |
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