Hyperglycemia Induces Cellular Hypoxia through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1.

Hyperglycemia Induces Cellular Hypoxia through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1.

We previously proposed that hyperglycemia-induced mitochondrial reactive oxygen species (mtROS) generation is a key event in the development of diabetic complications. Interestingly, some common aspects exist between hyperglycemia and hypoxia-induced phenomena. Thus, hyperglycemia may induce cellula...

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Bibliographic Details
Main Authors: Kiminori Sada, Takeshi Nishikawa, Daisuke Kukidome, Tomoaki Yoshinaga, Nobuhiro Kajihara, Kazuhiro Sonoda, Takafumi Senokuchi, Hiroyuki Motoshima, Takeshi Matsumura, Eiichi Araki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4934928?pdf=render

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