The Role of Canonical Wnt Signaling in Regulating Radioresistance
Radioresistance is a major obstacle in radiotherapy for cancer, and strategies are needed to overcome this problem. Currently, radiotherapy combined with targeted therapy such as inhibitors of phosphoinosotide 3-kinase/Akt and epidermal growth factor receptor signaling have become the focus of studi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Cell Physiol Biochem Press GmbH & Co KG
2018-07-01
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| Series: | Cellular Physiology and Biochemistry |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/491774 |
| _version_ | 1818788662327902208 |
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| author | Yuanyuan Zhao Leilei Tao Jun Yi Haizhu Song Longbang Chen |
| author_facet | Yuanyuan Zhao Leilei Tao Jun Yi Haizhu Song Longbang Chen |
| author_sort | Yuanyuan Zhao |
| collection | DOAJ |
| description | Radioresistance is a major obstacle in radiotherapy for cancer, and strategies are needed to overcome this problem. Currently, radiotherapy combined with targeted therapy such as inhibitors of phosphoinosotide 3-kinase/Akt and epidermal growth factor receptor signaling have become the focus of studies on radiosensitization. Apart from these two signaling pathways, which promote radioresistance, deregulation of Wnt signaling is also associated with the radioresistance of multiple cancers. Wnts, as important messengers in the tumor microenvironment, are involved in cancer progression mainly via canonical Wnt signaling. Their role in promoting DNA damage repair and inhibiting apoptosis facilitates cancer resistance to radiation. Thus, it seems reasonable to target Wnt signaling as a method for overcoming radioresistance. Many small-molecule inhibitors that target the Wnt signaling pathway have been identified and shown to promote radiosensitization. Therefore, a Wnt signaling inhibitor may help to overcome radioresistance in cancer therapy. |
| first_indexed | 2024-12-18T14:27:14Z |
| format | Article |
| id | doaj.art-1e8ed632cf71490eb80f62e9c2bcb782 |
| institution | Directory Open Access Journal |
| issn | 1015-8987 1421-9778 |
| language | English |
| last_indexed | 2024-12-18T14:27:14Z |
| publishDate | 2018-07-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
| record_format | Article |
| series | Cellular Physiology and Biochemistry |
| spelling | doaj.art-1e8ed632cf71490eb80f62e9c2bcb7822022-12-21T21:04:40ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782018-07-0148241943210.1159/000491774491774The Role of Canonical Wnt Signaling in Regulating RadioresistanceYuanyuan ZhaoLeilei TaoJun YiHaizhu SongLongbang ChenRadioresistance is a major obstacle in radiotherapy for cancer, and strategies are needed to overcome this problem. Currently, radiotherapy combined with targeted therapy such as inhibitors of phosphoinosotide 3-kinase/Akt and epidermal growth factor receptor signaling have become the focus of studies on radiosensitization. Apart from these two signaling pathways, which promote radioresistance, deregulation of Wnt signaling is also associated with the radioresistance of multiple cancers. Wnts, as important messengers in the tumor microenvironment, are involved in cancer progression mainly via canonical Wnt signaling. Their role in promoting DNA damage repair and inhibiting apoptosis facilitates cancer resistance to radiation. Thus, it seems reasonable to target Wnt signaling as a method for overcoming radioresistance. Many small-molecule inhibitors that target the Wnt signaling pathway have been identified and shown to promote radiosensitization. Therefore, a Wnt signaling inhibitor may help to overcome radioresistance in cancer therapy.https://www.karger.com/Article/FullText/491774RadioresistanceDNA repairROSApoptosisWnt/β-catenin |
| spellingShingle | Yuanyuan Zhao Leilei Tao Jun Yi Haizhu Song Longbang Chen The Role of Canonical Wnt Signaling in Regulating Radioresistance Cellular Physiology and Biochemistry Radioresistance DNA repair ROS Apoptosis Wnt/β-catenin |
| title | The Role of Canonical Wnt Signaling in Regulating Radioresistance |
| title_full | The Role of Canonical Wnt Signaling in Regulating Radioresistance |
| title_fullStr | The Role of Canonical Wnt Signaling in Regulating Radioresistance |
| title_full_unstemmed | The Role of Canonical Wnt Signaling in Regulating Radioresistance |
| title_short | The Role of Canonical Wnt Signaling in Regulating Radioresistance |
| title_sort | role of canonical wnt signaling in regulating radioresistance |
| topic | Radioresistance DNA repair ROS Apoptosis Wnt/β-catenin |
| url | https://www.karger.com/Article/FullText/491774 |
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