Effect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity on Peak Oxygen Uptake and Myocardial Fibrosis in Patients With Myocardial Infarction: Protocol for a Randomized Controlled Trial
IntroductionHigh-intensity interval training (HIIT) is an emerging method of cardiac rehabilitation, which is more and more popular in recent years. Research into the effect of HIIT on peak oxygen uptake (VO2 peak) and myocardial fibrosis among patients with myocardial infarction (MI) is lacking. He...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.860071/full |
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| author | Xiaohe Shi Xianyuan Chen Xinfan Qiu Wei Luo Xinyi Luo Hui Liu Qingshan Geng Huan Ma Ling Xue Lan Guo |
| author_facet | Xiaohe Shi Xianyuan Chen Xinfan Qiu Wei Luo Xinyi Luo Hui Liu Qingshan Geng Huan Ma Ling Xue Lan Guo |
| author_sort | Xiaohe Shi |
| collection | DOAJ |
| description | IntroductionHigh-intensity interval training (HIIT) is an emerging method of cardiac rehabilitation, which is more and more popular in recent years. Research into the effect of HIIT on peak oxygen uptake (VO2 peak) and myocardial fibrosis among patients with myocardial infarction (MI) is lacking. Here, we describe the rationale along with the protocol for a clinical trial to test the following hypotheses: (1) compared with the control group, VO2 peak will be increased in both the moderate-intensity continuous training (MICT) and HIIT groups and (2) compared with the control group, myocardial fibrosis due to MI will be improved by HIIT and MICT.Methods and AnalysisThis is a single-center, randomized controlled clinical trial. In total, 180 patients with MI are to be recruited for this study. VO2 peak will be tested by cardiopulmonary exercise testing (CPET) and myocardial fibrosis will be evaluated by cardiac MR. A variety of blood and psychometric tests and also the peripheral arterial tonometry, reactive hyperemia index for microvascular endothelial function, and microvascular blockage or digital vasomotor response are included.Ethics and DisseminationThe ethics committee of the Guangdong Provincial People's Hospital has authorized this mechanistic clinical research. Peer-reviewed articles and conference presentations will be used to disseminate the findings.Trial Registration NumberNCT04863677. |
| first_indexed | 2024-04-12T22:28:03Z |
| format | Article |
| id | doaj.art-1e90b3974aff4042a18fc948e1d26aaf |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-12T22:28:03Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-1e90b3974aff4042a18fc948e1d26aaf2022-12-22T03:14:04ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-04-01910.3389/fcvm.2022.860071860071Effect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity on Peak Oxygen Uptake and Myocardial Fibrosis in Patients With Myocardial Infarction: Protocol for a Randomized Controlled TrialXiaohe Shi0Xianyuan Chen1Xinfan Qiu2Wei Luo3Xinyi Luo4Hui Liu5Qingshan Geng6Huan Ma7Ling Xue8Lan Guo9Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaIntroductionHigh-intensity interval training (HIIT) is an emerging method of cardiac rehabilitation, which is more and more popular in recent years. Research into the effect of HIIT on peak oxygen uptake (VO2 peak) and myocardial fibrosis among patients with myocardial infarction (MI) is lacking. Here, we describe the rationale along with the protocol for a clinical trial to test the following hypotheses: (1) compared with the control group, VO2 peak will be increased in both the moderate-intensity continuous training (MICT) and HIIT groups and (2) compared with the control group, myocardial fibrosis due to MI will be improved by HIIT and MICT.Methods and AnalysisThis is a single-center, randomized controlled clinical trial. In total, 180 patients with MI are to be recruited for this study. VO2 peak will be tested by cardiopulmonary exercise testing (CPET) and myocardial fibrosis will be evaluated by cardiac MR. A variety of blood and psychometric tests and also the peripheral arterial tonometry, reactive hyperemia index for microvascular endothelial function, and microvascular blockage or digital vasomotor response are included.Ethics and DisseminationThe ethics committee of the Guangdong Provincial People's Hospital has authorized this mechanistic clinical research. Peer-reviewed articles and conference presentations will be used to disseminate the findings.Trial Registration NumberNCT04863677.https://www.frontiersin.org/articles/10.3389/fcvm.2022.860071/fullmyocardial infarctionhigh-intensity interval trainingmoderate continuous trainingpeak oxygen uptakemyocardial fibrosis |
| spellingShingle | Xiaohe Shi Xianyuan Chen Xinfan Qiu Wei Luo Xinyi Luo Hui Liu Qingshan Geng Huan Ma Ling Xue Lan Guo Effect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity on Peak Oxygen Uptake and Myocardial Fibrosis in Patients With Myocardial Infarction: Protocol for a Randomized Controlled Trial Frontiers in Cardiovascular Medicine myocardial infarction high-intensity interval training moderate continuous training peak oxygen uptake myocardial fibrosis |
| title | Effect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity on Peak Oxygen Uptake and Myocardial Fibrosis in Patients With Myocardial Infarction: Protocol for a Randomized Controlled Trial |
| title_full | Effect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity on Peak Oxygen Uptake and Myocardial Fibrosis in Patients With Myocardial Infarction: Protocol for a Randomized Controlled Trial |
| title_fullStr | Effect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity on Peak Oxygen Uptake and Myocardial Fibrosis in Patients With Myocardial Infarction: Protocol for a Randomized Controlled Trial |
| title_full_unstemmed | Effect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity on Peak Oxygen Uptake and Myocardial Fibrosis in Patients With Myocardial Infarction: Protocol for a Randomized Controlled Trial |
| title_short | Effect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity on Peak Oxygen Uptake and Myocardial Fibrosis in Patients With Myocardial Infarction: Protocol for a Randomized Controlled Trial |
| title_sort | effect of high intensity interval training moderate continuous training or guideline based physical activity on peak oxygen uptake and myocardial fibrosis in patients with myocardial infarction protocol for a randomized controlled trial |
| topic | myocardial infarction high-intensity interval training moderate continuous training peak oxygen uptake myocardial fibrosis |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.860071/full |
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