Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and Beyond
Caveolins, encoded by the CAV gene family, are the main protein components of caveolae. In most tissues, caveolin-1 (Cav-1) and caveolin-2 (Cav-2) are co-expressed, and Cav-2 targeting to caveolae depends on the formation of heterooligomers with Cav-1. Notwithstanding, Cav-2 has unpredictable activi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01530/full |
| _version_ | 1831842099470794752 |
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| author | Cecília Jacques Gonçalves de Almeida |
| author_facet | Cecília Jacques Gonçalves de Almeida |
| author_sort | Cecília Jacques Gonçalves de Almeida |
| collection | DOAJ |
| description | Caveolins, encoded by the CAV gene family, are the main protein components of caveolae. In most tissues, caveolin-1 (Cav-1) and caveolin-2 (Cav-2) are co-expressed, and Cav-2 targeting to caveolae depends on the formation of heterooligomers with Cav-1. Notwithstanding, Cav-2 has unpredictable activities, opposing Cav-1 in the regulation of some cellular processes. While the major roles of Cav-1 as a modulator of cell signaling in inflammatory processes and in immune responses have been extensively discussed elsewhere, the aim of this review is to focus on data revealing the distinct activity of Cav-1 and Cav-2, which suggest that these proteins act antagonistically to fine-tune a variety of cellular processes relevant to inflammation. |
| first_indexed | 2024-12-23T06:42:49Z |
| format | Article |
| id | doaj.art-1e92be89dce7445d9adef1659683029c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-23T06:42:49Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-1e92be89dce7445d9adef1659683029c2022-12-21T17:56:40ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-11-01810.3389/fimmu.2017.01530296189Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and BeyondCecília Jacques Gonçalves de Almeida0Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, BrazilCaveolins, encoded by the CAV gene family, are the main protein components of caveolae. In most tissues, caveolin-1 (Cav-1) and caveolin-2 (Cav-2) are co-expressed, and Cav-2 targeting to caveolae depends on the formation of heterooligomers with Cav-1. Notwithstanding, Cav-2 has unpredictable activities, opposing Cav-1 in the regulation of some cellular processes. While the major roles of Cav-1 as a modulator of cell signaling in inflammatory processes and in immune responses have been extensively discussed elsewhere, the aim of this review is to focus on data revealing the distinct activity of Cav-1 and Cav-2, which suggest that these proteins act antagonistically to fine-tune a variety of cellular processes relevant to inflammation.http://journal.frontiersin.org/article/10.3389/fimmu.2017.01530/fullcaveolincaveolaeinflammationinfectionfibrosisproliferation |
| spellingShingle | Cecília Jacques Gonçalves de Almeida Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and Beyond Frontiers in Immunology caveolin caveolae inflammation infection fibrosis proliferation |
| title | Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and Beyond |
| title_full | Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and Beyond |
| title_fullStr | Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and Beyond |
| title_full_unstemmed | Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and Beyond |
| title_short | Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and Beyond |
| title_sort | caveolin 1 and caveolin 2 can be antagonistic partners in inflammation and beyond |
| topic | caveolin caveolae inflammation infection fibrosis proliferation |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01530/full |
| work_keys_str_mv | AT ceciliajacquesgoncalvesdealmeida caveolin1andcaveolin2canbeantagonisticpartnersininflammationandbeyond |