Is translational research compatible with preclinical publication strategies?
<p>Abstract</p> <p>The term "translational research" is used to describe the transfer of basic biological knowledge into practical medicine, a process necessary for motivation of public spending. In the area of cancer therapeutics, it is becoming increasingly evident that...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2006-03-01
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| Series: | Radiation Oncology |
| Online Access: | http://www.ro-journal.com/content/1/1/4 |
| _version_ | 1828475006611357696 |
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| author | Shoshan Maria C Linder Stig |
| author_facet | Shoshan Maria C Linder Stig |
| author_sort | Shoshan Maria C |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The term "translational research" is used to describe the transfer of basic biological knowledge into practical medicine, a process necessary for motivation of public spending. In the area of cancer therapeutics, it is becoming increasingly evident that results obtained <it>in vitro </it>and in animal models are difficult to translate into clinical medicine. We here argue that a number of factors contribute to making the translation process inefficient. These factors include the use of sensitive cell lines and fast growing experimental tumors as targets for novel therapies, and the use of unrealistic drug concentrations and radiation doses. We also argue that aggressive interpretation of data, successful in hypothesis-building biological research, does not form a solid base for development of clinically useful treatment modalities. We question whether "clean" results obtained in simplified models, expected for publication in high-impact journals, represent solid foundations for improved treatment of patients. Open-access journals such as Radiation Oncology have a large mission to fulfill by publishing relevant data to be used for making actual progress in translational cancer research.</p> |
| first_indexed | 2024-12-11T06:07:37Z |
| format | Article |
| id | doaj.art-1e92cf8429964984b5c62439c1ba3624 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-12-11T06:07:37Z |
| publishDate | 2006-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-1e92cf8429964984b5c62439c1ba36242022-12-22T01:18:15ZengBMCRadiation Oncology1748-717X2006-03-0111410.1186/1748-717X-1-4Is translational research compatible with preclinical publication strategies?Shoshan Maria CLinder Stig<p>Abstract</p> <p>The term "translational research" is used to describe the transfer of basic biological knowledge into practical medicine, a process necessary for motivation of public spending. In the area of cancer therapeutics, it is becoming increasingly evident that results obtained <it>in vitro </it>and in animal models are difficult to translate into clinical medicine. We here argue that a number of factors contribute to making the translation process inefficient. These factors include the use of sensitive cell lines and fast growing experimental tumors as targets for novel therapies, and the use of unrealistic drug concentrations and radiation doses. We also argue that aggressive interpretation of data, successful in hypothesis-building biological research, does not form a solid base for development of clinically useful treatment modalities. We question whether "clean" results obtained in simplified models, expected for publication in high-impact journals, represent solid foundations for improved treatment of patients. Open-access journals such as Radiation Oncology have a large mission to fulfill by publishing relevant data to be used for making actual progress in translational cancer research.</p>http://www.ro-journal.com/content/1/1/4 |
| spellingShingle | Shoshan Maria C Linder Stig Is translational research compatible with preclinical publication strategies? Radiation Oncology |
| title | Is translational research compatible with preclinical publication strategies? |
| title_full | Is translational research compatible with preclinical publication strategies? |
| title_fullStr | Is translational research compatible with preclinical publication strategies? |
| title_full_unstemmed | Is translational research compatible with preclinical publication strategies? |
| title_short | Is translational research compatible with preclinical publication strategies? |
| title_sort | is translational research compatible with preclinical publication strategies |
| url | http://www.ro-journal.com/content/1/1/4 |
| work_keys_str_mv | AT shoshanmariac istranslationalresearchcompatiblewithpreclinicalpublicationstrategies AT linderstig istranslationalresearchcompatiblewithpreclinicalpublicationstrategies |