Ferroptosis as a potential new therapeutic target for diabetes and its complications
Diabetes is a complex metabolic disease. In recent years, diabetes and its chronic complications have become a health hotspot of global concern. I t is very important to find promising therapeutic targets and directions. Ferroptosis is a new type of programmed cell death that is different from cell...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2023-02-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/12/3/EC-22-0419.xml |
| _version_ | 1797894780637675520 |
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| author | Qian Deng Yue Zhu Mengmeng Zhang Aihua Fei Jiaqi Liang Jinjin Zheng Qingping Zhang Tong Cheng Xia Ge |
| author_facet | Qian Deng Yue Zhu Mengmeng Zhang Aihua Fei Jiaqi Liang Jinjin Zheng Qingping Zhang Tong Cheng Xia Ge |
| author_sort | Qian Deng |
| collection | DOAJ |
| description | Diabetes is a complex metabolic disease. In recent years, diabetes and its chronic complications have become a health hotspot of global concern. I t is very important to find promising therapeutic targets and directions. Ferroptosis is a new type of programmed cell death that is different from cell necrosis, apoptosis, and autop hagy. Ferroptosis is mainly characterized by iron-dependent lipid peroxidation. With the reduction of the anti-oxidative capacity of cells, the accumulated reactive lipid oxygen species will cause oxidative cell death and lead to ferroptosis at lethal levels. Recent studies have shown that ferroptosis plays an important regulatory role in the initiation and development of diabetes, as well as various complications of diabetes. In this review, we will summ arize new findings related to ferroptosis and diabetic complications and propose ferroptosis as a potential target for treating diabetic complications. |
| first_indexed | 2024-04-10T07:15:53Z |
| format | Article |
| id | doaj.art-1e93436761b74fb4a46e8a3364281426 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 |
| language | English |
| last_indexed | 2024-04-10T07:15:53Z |
| publishDate | 2023-02-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-1e93436761b74fb4a46e8a33642814262023-02-25T09:26:18ZengBioscientificaEndocrine Connections2049-36142023-02-01123114https://doi.org/10.1530/EC-22-0419Ferroptosis as a potential new therapeutic target for diabetes and its complicationsQian Deng0Yue Zhu1Mengmeng Zhang2Aihua Fei3Jiaqi Liang4Jinjin Zheng5Qingping Zhang6Tong Cheng7Xia Ge8Graduate College of Anhui University of Chinese Medicine, Hefei, ChinaGraduate College of Anhui University of Chinese Medicine, Hefei, ChinaGraduate College of Anhui University of Chinese Medicine, Hefei, ChinaDepartment of Endocrinology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaGraduate College of Anhui University of Chinese Medicine, Hefei, ChinaGraduate College of Anhui University of Chinese Medicine, Hefei, ChinaCollege of Acupuncture-moxibustion and Tuina , Anhui University of Chinese Medicine, Hefei, ChinaDepartment of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaDiabetes is a complex metabolic disease. In recent years, diabetes and its chronic complications have become a health hotspot of global concern. I t is very important to find promising therapeutic targets and directions. Ferroptosis is a new type of programmed cell death that is different from cell necrosis, apoptosis, and autop hagy. Ferroptosis is mainly characterized by iron-dependent lipid peroxidation. With the reduction of the anti-oxidative capacity of cells, the accumulated reactive lipid oxygen species will cause oxidative cell death and lead to ferroptosis at lethal levels. Recent studies have shown that ferroptosis plays an important regulatory role in the initiation and development of diabetes, as well as various complications of diabetes. In this review, we will summ arize new findings related to ferroptosis and diabetic complications and propose ferroptosis as a potential target for treating diabetic complications.https://ec.bioscientifica.com/view/journals/ec/12/3/EC-22-0419.xmlferroptosisdiabetesdiabetic complications |
| spellingShingle | Qian Deng Yue Zhu Mengmeng Zhang Aihua Fei Jiaqi Liang Jinjin Zheng Qingping Zhang Tong Cheng Xia Ge Ferroptosis as a potential new therapeutic target for diabetes and its complications Endocrine Connections ferroptosis diabetes diabetic complications |
| title | Ferroptosis as a potential new therapeutic target for diabetes and its complications |
| title_full | Ferroptosis as a potential new therapeutic target for diabetes and its complications |
| title_fullStr | Ferroptosis as a potential new therapeutic target for diabetes and its complications |
| title_full_unstemmed | Ferroptosis as a potential new therapeutic target for diabetes and its complications |
| title_short | Ferroptosis as a potential new therapeutic target for diabetes and its complications |
| title_sort | ferroptosis as a potential new therapeutic target for diabetes and its complications |
| topic | ferroptosis diabetes diabetic complications |
| url | https://ec.bioscientifica.com/view/journals/ec/12/3/EC-22-0419.xml |
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