X-ray repair cross-complementing protein 1 (XRCC1) loss promotes β-lapachone –induced apoptosis in pancreatic cancer cells

X-ray repair cross-complementing protein 1 (XRCC1) loss promotes β-lapachone –induced apoptosis in pancreatic cancer cells

Abstract Background β-lapachone (β-lap), the NQO1 bioactivatable drug, is thought to be a promising anticancer agent. However, the toxic side effects of β-lap limit the drug use, highlighting the need for a thorough understanding of β-lap’s mechanism of action. β-lap undergoes NQO1-dependent futile...

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Bibliographic Details
Main Authors: Yansong Zheng, Hengce Zhang, Yueting Guo, Yuan Chen, Hanglong Chen, Yingchun Liu
Format: Article
Language:English
Published: BMC 2021-11-01
Series:BMC Cancer
Subjects:
Pancreatic cancer
XRCC1
DNA BER
Apoptosis
Online Access:https://doi.org/10.1186/s12885-021-08979-y

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