Serum Procalcitonin in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. One of the most important events in the course of COPD is acute exacerbation. Acute exacerbation of COPD (AECOPD) is characterized by the aggravation of dyspnea, cough, and sputum. Chronic obstructive pulmona...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2021-03-01
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| Series: | Reviews in Clinical Medicine |
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| Online Access: | https://rcm.mums.ac.ir/article_18044_19e3e98c0c7f4c80ac18d893b878dc2b.pdf |
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| author | Farzaneh Akbari Mina Delghandi Fariba Rezaeetalab |
| author_facet | Farzaneh Akbari Mina Delghandi Fariba Rezaeetalab |
| author_sort | Farzaneh Akbari |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. One of the most important events in the course of COPD is acute exacerbation. Acute exacerbation of COPD (AECOPD) is characterized by the aggravation of dyspnea, cough, and sputum. Chronic obstructive pulmonary disease exacerbation leads to respiratory failure, hospitalization, morbidity, and mortality. During and after the COPD attack, lung function dramatically decreased. Bacterial pneumonia is an important and serious risk factor for AECOPD. However, there are other inflammatory and non-inflammatory causes of AECOPD. Antibiotic treatment is usually challenging in AECOPD. Procalcitonin is a non-hormone active protein and precursor to calcitonin that consists of 116 amino acids, and 13 kDa weight is produced by the neuroendocrine cells of the thyroid gland. However, procalcitonin is secreted in septic shock, metastatic cancers, bacterial and fungal infections; therefore, serum procalcitonin is increased in bacterial pneumonia of AECOPD. Some studies recommended procalcitonin serum measurement as a guide for antibiotic initiation in AECOPD. |
| first_indexed | 2024-12-16T18:41:21Z |
| format | Article |
| id | doaj.art-1e94cbc9706d46dd9a4d58f7ef76e112 |
| institution | Directory Open Access Journal |
| issn | 2345-6256 2345-6892 |
| language | English |
| last_indexed | 2024-12-16T18:41:21Z |
| publishDate | 2021-03-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Reviews in Clinical Medicine |
| spelling | doaj.art-1e94cbc9706d46dd9a4d58f7ef76e1122022-12-21T22:21:02ZengMashhad University of Medical SciencesReviews in Clinical Medicine2345-62562345-68922021-03-0181273010.22038/rcm.2021.56075.135918044Serum Procalcitonin in Chronic Obstructive Pulmonary DiseaseFarzaneh Akbari0Mina Delghandi1Fariba Rezaeetalab21Resident of internal medicine, school of medicine, Mashhad university of Medical Sciences, Mashhad. Iran.Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad. Iran.Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad. Iran.Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. One of the most important events in the course of COPD is acute exacerbation. Acute exacerbation of COPD (AECOPD) is characterized by the aggravation of dyspnea, cough, and sputum. Chronic obstructive pulmonary disease exacerbation leads to respiratory failure, hospitalization, morbidity, and mortality. During and after the COPD attack, lung function dramatically decreased. Bacterial pneumonia is an important and serious risk factor for AECOPD. However, there are other inflammatory and non-inflammatory causes of AECOPD. Antibiotic treatment is usually challenging in AECOPD. Procalcitonin is a non-hormone active protein and precursor to calcitonin that consists of 116 amino acids, and 13 kDa weight is produced by the neuroendocrine cells of the thyroid gland. However, procalcitonin is secreted in septic shock, metastatic cancers, bacterial and fungal infections; therefore, serum procalcitonin is increased in bacterial pneumonia of AECOPD. Some studies recommended procalcitonin serum measurement as a guide for antibiotic initiation in AECOPD.https://rcm.mums.ac.ir/article_18044_19e3e98c0c7f4c80ac18d893b878dc2b.pdfprocalcitonincopdexacerbation |
| spellingShingle | Farzaneh Akbari Mina Delghandi Fariba Rezaeetalab Serum Procalcitonin in Chronic Obstructive Pulmonary Disease Reviews in Clinical Medicine procalcitonin copd exacerbation |
| title | Serum Procalcitonin in Chronic Obstructive Pulmonary Disease |
| title_full | Serum Procalcitonin in Chronic Obstructive Pulmonary Disease |
| title_fullStr | Serum Procalcitonin in Chronic Obstructive Pulmonary Disease |
| title_full_unstemmed | Serum Procalcitonin in Chronic Obstructive Pulmonary Disease |
| title_short | Serum Procalcitonin in Chronic Obstructive Pulmonary Disease |
| title_sort | serum procalcitonin in chronic obstructive pulmonary disease |
| topic | procalcitonin copd exacerbation |
| url | https://rcm.mums.ac.ir/article_18044_19e3e98c0c7f4c80ac18d893b878dc2b.pdf |
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