Plant-Derived <i>Lactobacillus paracasei</i> IJH-SONE68 Improves Chronic Allergy Status: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
We have recently demonstrated that the exopolysaccharides (EPSs) produced by a plant-derived lactic acid bacterium, <i>Lactobacillus paracasei</i> IJH-SONE68, prevent and ameliorate allergic reaction on contact in dermatitis model mice. In the present study, we conducted a clinical trial...
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MDPI AG
2021-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/11/4022 |
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| author | Masafumi Noda Keishi Kanno Narandalai Danshiitsoodol Fumiko Higashikawa Masanori Sugiyama |
| author_facet | Masafumi Noda Keishi Kanno Narandalai Danshiitsoodol Fumiko Higashikawa Masanori Sugiyama |
| author_sort | Masafumi Noda |
| collection | DOAJ |
| description | We have recently demonstrated that the exopolysaccharides (EPSs) produced by a plant-derived lactic acid bacterium, <i>Lactobacillus paracasei</i> IJH-SONE68, prevent and ameliorate allergic reaction on contact in dermatitis model mice. In the present study, we conducted a clinical trial using a capsule containing spray-dried powder from pineapple juice broth fermented with the LAB strain as an experimental diet. The clinical trial was conducted as a double-blind and placebo-controlled randomized comparative study from May 2019 to July 2021. Males and females between the ages of 21 and 70 who experience chronic allergies participated in the study. Sixty subjects were instructed to orally take a capsule containing the IJH-SONE68 powder or placebo, every day for 12 weeks. After the clinical trial was over, the scores based on subjects’ self-assessment of allergic status were significantly improved in the intervention group, as compared with the placebo group. Some serum biochemicals associated with inflammation response were also significantly improved by intake of the experimental diet. In conclusion, the IJH-SONE68-derived EPS improves chronic allergy status in humans and is expected to decrease their inconvenience. |
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| id | doaj.art-1e957094058d44a9b3ce22edc065e865 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T05:10:37Z |
| publishDate | 2021-11-01 |
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| series | Nutrients |
| spelling | doaj.art-1e957094058d44a9b3ce22edc065e8652023-11-23T00:49:27ZengMDPI AGNutrients2072-66432021-11-011311402210.3390/nu13114022Plant-Derived <i>Lactobacillus paracasei</i> IJH-SONE68 Improves Chronic Allergy Status: A Randomized, Double-Blind, Placebo-Controlled Clinical TrialMasafumi Noda0Keishi Kanno1Narandalai Danshiitsoodol2Fumiko Higashikawa3Masanori Sugiyama4Department of Probiotic Science for Preventive Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1–2–3, Minami-ku, Hiroshima 734-8551, JapanDepartment of General Internal Medicine, Hiroshima University Hospital, Kasumi 1–2–3, Minami-Ku, Hiroshima 734-8551, JapanDepartment of Probiotic Science for Preventive Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1–2–3, Minami-ku, Hiroshima 734-8551, JapanDepartment of Probiotic Science for Preventive Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1–2–3, Minami-ku, Hiroshima 734-8551, JapanDepartment of Probiotic Science for Preventive Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1–2–3, Minami-ku, Hiroshima 734-8551, JapanWe have recently demonstrated that the exopolysaccharides (EPSs) produced by a plant-derived lactic acid bacterium, <i>Lactobacillus paracasei</i> IJH-SONE68, prevent and ameliorate allergic reaction on contact in dermatitis model mice. In the present study, we conducted a clinical trial using a capsule containing spray-dried powder from pineapple juice broth fermented with the LAB strain as an experimental diet. The clinical trial was conducted as a double-blind and placebo-controlled randomized comparative study from May 2019 to July 2021. Males and females between the ages of 21 and 70 who experience chronic allergies participated in the study. Sixty subjects were instructed to orally take a capsule containing the IJH-SONE68 powder or placebo, every day for 12 weeks. After the clinical trial was over, the scores based on subjects’ self-assessment of allergic status were significantly improved in the intervention group, as compared with the placebo group. Some serum biochemicals associated with inflammation response were also significantly improved by intake of the experimental diet. In conclusion, the IJH-SONE68-derived EPS improves chronic allergy status in humans and is expected to decrease their inconvenience.https://www.mdpi.com/2072-6643/13/11/4022<i>Lactobacillus paracasei</i>chronic allergyclinical trialplant-derived lactic acid bacteriumanti-inflammation |
| spellingShingle | Masafumi Noda Keishi Kanno Narandalai Danshiitsoodol Fumiko Higashikawa Masanori Sugiyama Plant-Derived <i>Lactobacillus paracasei</i> IJH-SONE68 Improves Chronic Allergy Status: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Nutrients <i>Lactobacillus paracasei</i> chronic allergy clinical trial plant-derived lactic acid bacterium anti-inflammation |
| title | Plant-Derived <i>Lactobacillus paracasei</i> IJH-SONE68 Improves Chronic Allergy Status: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| title_full | Plant-Derived <i>Lactobacillus paracasei</i> IJH-SONE68 Improves Chronic Allergy Status: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| title_fullStr | Plant-Derived <i>Lactobacillus paracasei</i> IJH-SONE68 Improves Chronic Allergy Status: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| title_full_unstemmed | Plant-Derived <i>Lactobacillus paracasei</i> IJH-SONE68 Improves Chronic Allergy Status: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| title_short | Plant-Derived <i>Lactobacillus paracasei</i> IJH-SONE68 Improves Chronic Allergy Status: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| title_sort | plant derived i lactobacillus paracasei i ijh sone68 improves chronic allergy status a randomized double blind placebo controlled clinical trial |
| topic | <i>Lactobacillus paracasei</i> chronic allergy clinical trial plant-derived lactic acid bacterium anti-inflammation |
| url | https://www.mdpi.com/2072-6643/13/11/4022 |
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