Can Ultrasound and Contrast-Enhanced Ultrasound Help Differentiate between Subpleural Focal Organizing Pneumonia and Primary Lung Malignancy?
Background: Subpleural focal organizing pneumonia (FOP) and primary lung malignancy (PLM) are usually confused. The aim of this study was to explore the value of ultrasound (US) and contrast-enhanced ultrasound (CEUS) in the differential diagnosis of FOP and PLM. Methods: A total of 23 patients (mea...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/9/2074 |
| _version_ | 1797489512714076160 |
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| author | Ying Fu Yutao Lei Ligang Cui Tingting Du Fang Mei |
| author_facet | Ying Fu Yutao Lei Ligang Cui Tingting Du Fang Mei |
| author_sort | Ying Fu |
| collection | DOAJ |
| description | Background: Subpleural focal organizing pneumonia (FOP) and primary lung malignancy (PLM) are usually confused. The aim of this study was to explore the value of ultrasound (US) and contrast-enhanced ultrasound (CEUS) in the differential diagnosis of FOP and PLM. Methods: A total of 23 patients (mean age: 64.57 ± 11.86 years) with FOP and 100 (mean age: 66.29 ± 11.05 years) with subpleural lesions diagnosed as PLM, confirmed by pathological diagnosis and clinical follow-up, were retrospectively enrolled. The largest lesion diameter, angle between the lesion border and thoracic wall, air bronchial sign, internal blood supply, blood supply form, and pleural effusion examined using conventional US were retrospectively analyzed. The indicators of CEUS included the arrival time of contrast agent in the lesion, lesion–lung arrival time difference, degree of enhancement, distribution uniformity of contrast medium, presence of non-enhancing region, and arterial filling mode in the lesion. A <i>p</i> < 0.05 was considered statistically significant. Results: Presence of air bronchial sign (odds ratio [OR] = 6.18, <i>p</i> = 0.025), acute angle between the lesion border and thoracic wall (OR = 7.124, <i>p</i> = 0.033), and homogeneous enhancement (OR = 35.26, <i>p</i> = 0.01) showed predictive value for the diagnosis of FOP. According to the results of the logistic regression analysis, the area under the receiver operating curve of the above features combined was 0.960, and the sensitivity and specificity were 95.0% and 82.6%, respectively. Conclusions: US combined with CEUS has the potential to differentiate between FOP and PLM. |
| first_indexed | 2024-03-10T00:17:39Z |
| format | Article |
| id | doaj.art-1e9a95c0cc45406fbbe382fe6c165b4d |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T00:17:39Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-1e9a95c0cc45406fbbe382fe6c165b4d2023-11-23T15:48:19ZengMDPI AGDiagnostics2075-44182022-08-01129207410.3390/diagnostics12092074Can Ultrasound and Contrast-Enhanced Ultrasound Help Differentiate between Subpleural Focal Organizing Pneumonia and Primary Lung Malignancy?Ying Fu0Yutao Lei1Ligang Cui2Tingting Du3Fang Mei4Department of Ultrasound, Peking University Third Hospital, Beijing 100191, ChinaDepartment of General Surgery, Peking University Third Hospital, Beijing 100191, ChinaDepartment of Ultrasound, Peking University Third Hospital, Beijing 100191, ChinaDepartment of Ultrasound, Peking University Third Hospital, Beijing 100191, ChinaDepartment of Pathology, Peking University Third Hospital, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, ChinaBackground: Subpleural focal organizing pneumonia (FOP) and primary lung malignancy (PLM) are usually confused. The aim of this study was to explore the value of ultrasound (US) and contrast-enhanced ultrasound (CEUS) in the differential diagnosis of FOP and PLM. Methods: A total of 23 patients (mean age: 64.57 ± 11.86 years) with FOP and 100 (mean age: 66.29 ± 11.05 years) with subpleural lesions diagnosed as PLM, confirmed by pathological diagnosis and clinical follow-up, were retrospectively enrolled. The largest lesion diameter, angle between the lesion border and thoracic wall, air bronchial sign, internal blood supply, blood supply form, and pleural effusion examined using conventional US were retrospectively analyzed. The indicators of CEUS included the arrival time of contrast agent in the lesion, lesion–lung arrival time difference, degree of enhancement, distribution uniformity of contrast medium, presence of non-enhancing region, and arterial filling mode in the lesion. A <i>p</i> < 0.05 was considered statistically significant. Results: Presence of air bronchial sign (odds ratio [OR] = 6.18, <i>p</i> = 0.025), acute angle between the lesion border and thoracic wall (OR = 7.124, <i>p</i> = 0.033), and homogeneous enhancement (OR = 35.26, <i>p</i> = 0.01) showed predictive value for the diagnosis of FOP. According to the results of the logistic regression analysis, the area under the receiver operating curve of the above features combined was 0.960, and the sensitivity and specificity were 95.0% and 82.6%, respectively. Conclusions: US combined with CEUS has the potential to differentiate between FOP and PLM.https://www.mdpi.com/2075-4418/12/9/2074contrast-enhanced ultrasoundorganizing pneumoniafocalprimary lung malignancysubpleural |
| spellingShingle | Ying Fu Yutao Lei Ligang Cui Tingting Du Fang Mei Can Ultrasound and Contrast-Enhanced Ultrasound Help Differentiate between Subpleural Focal Organizing Pneumonia and Primary Lung Malignancy? Diagnostics contrast-enhanced ultrasound organizing pneumonia focal primary lung malignancy subpleural |
| title | Can Ultrasound and Contrast-Enhanced Ultrasound Help Differentiate between Subpleural Focal Organizing Pneumonia and Primary Lung Malignancy? |
| title_full | Can Ultrasound and Contrast-Enhanced Ultrasound Help Differentiate between Subpleural Focal Organizing Pneumonia and Primary Lung Malignancy? |
| title_fullStr | Can Ultrasound and Contrast-Enhanced Ultrasound Help Differentiate between Subpleural Focal Organizing Pneumonia and Primary Lung Malignancy? |
| title_full_unstemmed | Can Ultrasound and Contrast-Enhanced Ultrasound Help Differentiate between Subpleural Focal Organizing Pneumonia and Primary Lung Malignancy? |
| title_short | Can Ultrasound and Contrast-Enhanced Ultrasound Help Differentiate between Subpleural Focal Organizing Pneumonia and Primary Lung Malignancy? |
| title_sort | can ultrasound and contrast enhanced ultrasound help differentiate between subpleural focal organizing pneumonia and primary lung malignancy |
| topic | contrast-enhanced ultrasound organizing pneumonia focal primary lung malignancy subpleural |
| url | https://www.mdpi.com/2075-4418/12/9/2074 |
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