Searching for the Achilles heel of FOXP3

Searching for the Achilles heel of FOXP3

FOXP3 is a multifaceted transcription factor with a major role in the control of immune homeostasis mediated by T regulatory cells (Treg). The immunoregulatory function of FOXP3 may hinder the induction of immune responses against cancer and infectious agents, and thus, development of inhibitors of...

Full description

Bibliographic Details
Main Authors:	Teresa eLozano, Noelia eCasares, Juan José Lasarte
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2013-12-01
Series:	Frontiers in Oncology
Subjects:	Drug Discovery Immunosuppression Foxp3 Treg FOXP3 interactome
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00294/full

Similar Items

Molecular Mechanisms Controlling Foxp3 Expression in Health and Autoimmunity: From Epigenetic to Post-translational Regulation
by: Alessandra Colamatteo, et al.
Published: (2020-02-01)

Anti-regulatory T cell vaccines in immunotherapy: focusing on FoxP3 as target
by: Neda Mousavi-Niri, et al.
Published: (2019-03-01)

Peripheral and Thymic Foxp3+ Regulatory T Cells in Search of Origin, Distinction and Function
by: Chetan eDhamne, et al.
Published: (2013-08-01)

Analysis of selected polymorphisms in FOXP3 gene in a cohort of Egyptian patients with schizophrenia
by: Maged Mostafa, et al.
Published: (2022-05-01)

The correlation of Foxp3 + gene and regulatory T cells with scar BCG formation among children with Tuberculosis
by: Farsida, et al.
Published: (2020-12-01)

Regulation of CD8+ T cell responses to retinal antigen by local FoxP3+ regulatory T cells
by: Scott W McPherson, et al.
Published: (2012-06-01)

Cryptotanshinone possesses therapeutic effects on ischaemic stroke through regulating STAT5 in a rat model
by: Feihong Zhu, et al.
Published: (2021-01-01)

FOXP3+ Treg cells and its gender bias in autoimmune diseases
by: Jia eNie, et al.
Published: (2015-09-01)

Distribution of FoxP3+regulatoryT-cells in rat’spancreatic lymph nodes under streptozotocin-induced diabetes and metformin administration
by: D. A. Putilin, et al.
Published: (2015-04-01)

Beyond FOXP3: a 20-year journey unravelling human regulatory T-cell heterogeneity
by: Samikshya Santosh Nirmala, et al.
Published: (2024-01-01)

BATF is Required for Treg Homeostasis and Stability to Prevent Autoimmune Pathology
by: Achia Khatun, et al.
Published: (2023-10-01)

The Role of T Regulatory Lymphocytes in Lymphoma
by: Ahmad Nasser, et al.
Published: (2014-03-01)

Baicalin, a natural compound, promotes regulatory T cell differentiation
by: Yang Ji, et al.
Published: (2012-05-01)

CO-evaluation of Immunhistochemical PD-L1 and FOXP3 Expressions in Breast Cancer
by: Özge KAYA KORKMAZ, et al.
Published: (2023-07-01)

The prognostic value of intratumoral and peritumoral tumor-infiltrating FoxP3+Treg cells in of pancreatic adenocarcinoma: a meta-analysis
by: Lingyu Hu, et al.
Published: (2021-10-01)

CXCL4 promoted the production of CD4+CD25+FOXP3+treg cells in mouse sepsis model through regulating STAT5/FOXP3 pathway
by: Tao Xu, et al.
Published: (2020-07-01)

Foxp3 Instability Helps tTregs Distinguish Self and Non-self
by: Zhongmei Zhang, et al.
Published: (2019-09-01)

Investigation on the regulatory T cells signature and relevant Foxp3/STAT3 axis in esophageal cancer
by: Lin Yang, et al.
Published: (2023-02-01)

A GMCSF-Neuroantigen Tolerogenic Vaccine Elicits Systemic Lymphocytosis of CD4+ CD25high FOXP3+ Regulatory T Cells in Myelin-Specific TCR Transgenic Mice Contingent Upon Low-Efficiency T Cell Antigen Receptor Recognition
by: Cody D. Moorman, et al.
Published: (2019-01-01)

Intratumoral expression of FoxP3-positive regulatory T-cells in T-cell lymphoma: no correlation with survival
by: Josefine Lundberg, et al.
Published: (2019-04-01)

Aptamer-mediated transcriptional gene silencing of Foxp3 inhibits regulatory T cells and potentiates antitumor response
by: Andrea J. Manrique-Rincón, et al.
Published: (2021-09-01)

Peran Penting Sel T Regulator CD8+CD25+FOXP3+ Menjaga Homeostasis Sel T pada Transplantasi Alogenik (ESSENTIAL ROLES OF CD8+CD25+FOXP3+ REGULATORY T CELLS IN THE MAINTENANCE OF T CELLS HOMEOSTASIS IN ALLOGENEIC TRANSPLANTATION)
by: Muhaimin Rifa’i, et al.
Published: (2013-12-01)

CD4+FOXP3+ Regulatory T Cell Subsets in Human Immunodeficiency Virus (HIV) Infection
by: Federico eSimonetta, et al.
Published: (2013-07-01)

Perinatal tissue-derived exosomes ameliorate colitis in mice by regulating the Foxp3 + Treg cells and gut microbiota
by: Yaping Yan, et al.
Published: (2023-03-01)

Foxp3 Molecular Dynamics in Treg in Juvenile Idiopathic Arthritis
by: Alastair Copland, et al.
Published: (2018-10-01)

Alloantigen-Induced Regulatory T Cells Generated in Presence of Vitamin C Display Enhanced Stability of Foxp3 Expression and Promote Skin Allograft Acceptance
by: Eirini Nikolouli, et al.
Published: (2017-06-01)

IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A+Foxp3+ Cells During Mucosal Infection and Is Dysregulated With Aging
by: Natarajan Bhaskaran, et al.
Published: (2020-11-01)

The Dynamic Role of FOXP3+ Tregs and Their Potential Therapeutic Applications During SARS-CoV-2 Infection
by: Zhan Xu, et al.
Published: (2022-07-01)

Neuropilin-1 in Transplantation Tolerance
by: Mauricio eCampos-Mora, et al.
Published: (2013-11-01)

Deciphering the developmental trajectory of tissue-resident Foxp3+ regulatory T cells
by: Fernando Alvarez, et al.
Published: (2024-03-01)

Natural and induced T regulatory cells in cancer
by: Dennis O Adeegbe, et al.
Published: (2013-07-01)

Foxp3+ Regulatory T Cells in Bone and Hematopoietic Homeostasis
by: Luise Fischer, et al.
Published: (2019-09-01)

Generation of RORγt+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity
by: Byung-Seok Kim, et al.
Published: (2017-10-01)

FOXP3 Isoforms Expression in Cervical Cancer: Evidence about the Cancer-Related Properties of FOXP3Δ2Δ7 in Keratinocytes
by: Natalia Garcia-Becerra, et al.
Published: (2023-01-01)

Critical Role of TGF-β and IL-2 Receptor Signaling in Foxp3 Induction by an Inhibitor of DNA Methylation
by: Kristin Freudenberg, et al.
Published: (2018-02-01)

Reprogrammed CD4+ T Cells That Express FoxP3+ Control Inhibitory Antibody Formation in Hemophilia A Mice
by: Roland W. Herzog, et al.
Published: (2019-02-01)

Investigating Prevalence of FOXP3 Gene Polymorphism in Multiple Sclerosis
by: R Rahnama, et al.
Published: (2015-02-01)

CRISPRa-mediated FOXP3 gene upregulation in mammalian cells
by: Vida Forstnerič, et al.
Published: (2019-11-01)

Asiaticoside ameliorates renal ischemia/reperfusion injury by promoting CD4+CD25+FOXP3+ treg cell differentiation
by: Shengjie Tang, et al.
Published: (2023-07-01)

KLRG1 expression identifies short-lived Foxp3+ Treg effector cells with functional plasticity in islets of NOD mice
by: Mara Kornete, et al.
Published: (2017-08-01)