Seroprevalence of mumps in The Netherlands: dynamics over a decade with high vaccination coverage and recent outbreaks.
Here we present mumps virus specific antibody levels in a large cross-sectional population-based serosurveillance study performed in the Netherlands in 2006/2007 (n = 7900). Results were compared with a similar study (1995/1996) and discussed in the light of recent outbreaks. Mumps antibodies were t...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3592917?pdf=render |
| _version_ | 1828910044824993792 |
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| author | Gaby Smits Liesbeth Mollema Susan Hahné Hester de Melker Irina Tcherniaeva Sandra Waaijenborg Rob van Binnendijk Fiona van der Klis Guy Berbers |
| author_facet | Gaby Smits Liesbeth Mollema Susan Hahné Hester de Melker Irina Tcherniaeva Sandra Waaijenborg Rob van Binnendijk Fiona van der Klis Guy Berbers |
| author_sort | Gaby Smits |
| collection | DOAJ |
| description | Here we present mumps virus specific antibody levels in a large cross-sectional population-based serosurveillance study performed in the Netherlands in 2006/2007 (n = 7900). Results were compared with a similar study (1995/1996) and discussed in the light of recent outbreaks. Mumps antibodies were tested using a fluorescent bead-based multiplex immunoassay. Overall seroprevalence was 90.9% with higher levels in the naturally infected cohorts compared with vaccinated cohorts. Mumps virus vaccinations at 14 months and 9 years resulted in an increased seroprevalence and antibody concentration. The second vaccination seemed to be important in acquiring stable mumps antibody levels in the long term. In conclusion, the Dutch population is well protected against mumps virus infection. However, we identified specific age- and population groups at increased risk of mumps infection. Indeed, in 2007/2008 an outbreak has occurred in the low vaccination coverage groups emphasizing the predictive value of serosurveillance studies. |
| first_indexed | 2024-12-13T18:36:14Z |
| format | Article |
| id | doaj.art-1e9c1a6fd44f4389bcac73bf3fcfc6ca |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T18:36:14Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1e9c1a6fd44f4389bcac73bf3fcfc6ca2022-12-21T23:35:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0183e5823410.1371/journal.pone.0058234Seroprevalence of mumps in The Netherlands: dynamics over a decade with high vaccination coverage and recent outbreaks.Gaby SmitsLiesbeth MollemaSusan HahnéHester de MelkerIrina TcherniaevaSandra WaaijenborgRob van BinnendijkFiona van der KlisGuy BerbersHere we present mumps virus specific antibody levels in a large cross-sectional population-based serosurveillance study performed in the Netherlands in 2006/2007 (n = 7900). Results were compared with a similar study (1995/1996) and discussed in the light of recent outbreaks. Mumps antibodies were tested using a fluorescent bead-based multiplex immunoassay. Overall seroprevalence was 90.9% with higher levels in the naturally infected cohorts compared with vaccinated cohorts. Mumps virus vaccinations at 14 months and 9 years resulted in an increased seroprevalence and antibody concentration. The second vaccination seemed to be important in acquiring stable mumps antibody levels in the long term. In conclusion, the Dutch population is well protected against mumps virus infection. However, we identified specific age- and population groups at increased risk of mumps infection. Indeed, in 2007/2008 an outbreak has occurred in the low vaccination coverage groups emphasizing the predictive value of serosurveillance studies.http://europepmc.org/articles/PMC3592917?pdf=render |
| spellingShingle | Gaby Smits Liesbeth Mollema Susan Hahné Hester de Melker Irina Tcherniaeva Sandra Waaijenborg Rob van Binnendijk Fiona van der Klis Guy Berbers Seroprevalence of mumps in The Netherlands: dynamics over a decade with high vaccination coverage and recent outbreaks. PLoS ONE |
| title | Seroprevalence of mumps in The Netherlands: dynamics over a decade with high vaccination coverage and recent outbreaks. |
| title_full | Seroprevalence of mumps in The Netherlands: dynamics over a decade with high vaccination coverage and recent outbreaks. |
| title_fullStr | Seroprevalence of mumps in The Netherlands: dynamics over a decade with high vaccination coverage and recent outbreaks. |
| title_full_unstemmed | Seroprevalence of mumps in The Netherlands: dynamics over a decade with high vaccination coverage and recent outbreaks. |
| title_short | Seroprevalence of mumps in The Netherlands: dynamics over a decade with high vaccination coverage and recent outbreaks. |
| title_sort | seroprevalence of mumps in the netherlands dynamics over a decade with high vaccination coverage and recent outbreaks |
| url | http://europepmc.org/articles/PMC3592917?pdf=render |
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