Molecular prevalence of Coxiella burnetii in bulk-tank milk from bovine dairy herds: Systematic review and meta-analysis
Coxiella burnetii is an obligate intracellular zoonotic bacterium that causes Q fever. Ruminants, including cattle, are broadly known to be reservoirs for this bacterium. Since 2006, many research groups have evaluated the herd-level prevalence of C. burnetii in cattle by molecular techniques on com...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | One Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352771420303098 |
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| author | Ana Rabaza Martín Fraga Luis Gustavo Corbellini Katy M.E. Turner Franklin Riet-Correa Mark C. Eisler |
| author_facet | Ana Rabaza Martín Fraga Luis Gustavo Corbellini Katy M.E. Turner Franklin Riet-Correa Mark C. Eisler |
| author_sort | Ana Rabaza |
| collection | DOAJ |
| description | Coxiella burnetii is an obligate intracellular zoonotic bacterium that causes Q fever. Ruminants, including cattle, are broadly known to be reservoirs for this bacterium. Since 2006, many research groups have evaluated the herd-level prevalence of C. burnetii in cattle by molecular techniques on composite milk samples. This study explored the global C. burnetii herd-level prevalence from studies done on bovine bulk-tank milk (BTM) samples using PCR-based analysis. Also, moderators were investigated to identify sources of heterogeneity. Databases (CAB Abstracts, Medline via Ovid, PubMed, Web of Science and Google Scholar) were searched for index articles on C. burnetii prevalence in BTM samples by PCR published between January-1973 and November-2018. Numerous studies (1054) were initially identified, from which seventeen original publications were included in the meta-analysis based on the pre-defined selection criteria. These studies comprised 4031 BTM samples from twelve countries. A random-effects model was used because of considerable heterogeneity (I2 = 98%) to estimate the herd-level prevalence of C. burnetii as 37.0%(CI95%25.2–49.5%). The average herd size appeared to account for a high level of the heterogeneity. No other moderators (geographic location, gross national income or notification criteria for Q fever) seemed to be determinant. This systematic evaluation demonstrated a high molecular prevalence of C. burnetii in BTM samples both in European and non-European countries, evidencing a widespread herd-level circulation of this agent in bovine dairy farms around the world. Meta-regression showed herd size as the most relevant moderator with the odds of a BTM sample testing positive doubling with every unit increase. |
| first_indexed | 2024-12-17T08:31:02Z |
| format | Article |
| id | doaj.art-1e9c52152e6c4752958f369c4ba9cacb |
| institution | Directory Open Access Journal |
| issn | 2352-7714 |
| language | English |
| last_indexed | 2024-12-17T08:31:02Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
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| series | One Health |
| spelling | doaj.art-1e9c52152e6c4752958f369c4ba9cacb2022-12-21T21:56:36ZengElsevierOne Health2352-77142021-06-0112100208Molecular prevalence of Coxiella burnetii in bulk-tank milk from bovine dairy herds: Systematic review and meta-analysisAna Rabaza0Martín Fraga1Luis Gustavo Corbellini2Katy M.E. Turner3Franklin Riet-Correa4Mark C. Eisler5Plataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria (INIA), Estación Experimental La Estanzuela, Ruta 50 Km 11, Colonia, Uruguay; Bristol Veterinary School, University of Bristol, Langford House, Langford, Bristol BS40 5DU, UKPlataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria (INIA), Estación Experimental La Estanzuela, Ruta 50 Km 11, Colonia, UruguayPlataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria (INIA), Estación Experimental La Estanzuela, Ruta 50 Km 11, Colonia, UruguayBristol Veterinary School, University of Bristol, Langford House, Langford, Bristol BS40 5DU, UKPlataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria (INIA), Estación Experimental La Estanzuela, Ruta 50 Km 11, Colonia, UruguayBristol Veterinary School, University of Bristol, Langford House, Langford, Bristol BS40 5DU, UK; Corresponding author.Coxiella burnetii is an obligate intracellular zoonotic bacterium that causes Q fever. Ruminants, including cattle, are broadly known to be reservoirs for this bacterium. Since 2006, many research groups have evaluated the herd-level prevalence of C. burnetii in cattle by molecular techniques on composite milk samples. This study explored the global C. burnetii herd-level prevalence from studies done on bovine bulk-tank milk (BTM) samples using PCR-based analysis. Also, moderators were investigated to identify sources of heterogeneity. Databases (CAB Abstracts, Medline via Ovid, PubMed, Web of Science and Google Scholar) were searched for index articles on C. burnetii prevalence in BTM samples by PCR published between January-1973 and November-2018. Numerous studies (1054) were initially identified, from which seventeen original publications were included in the meta-analysis based on the pre-defined selection criteria. These studies comprised 4031 BTM samples from twelve countries. A random-effects model was used because of considerable heterogeneity (I2 = 98%) to estimate the herd-level prevalence of C. burnetii as 37.0%(CI95%25.2–49.5%). The average herd size appeared to account for a high level of the heterogeneity. No other moderators (geographic location, gross national income or notification criteria for Q fever) seemed to be determinant. This systematic evaluation demonstrated a high molecular prevalence of C. burnetii in BTM samples both in European and non-European countries, evidencing a widespread herd-level circulation of this agent in bovine dairy farms around the world. Meta-regression showed herd size as the most relevant moderator with the odds of a BTM sample testing positive doubling with every unit increase.http://www.sciencedirect.com/science/article/pii/S2352771420303098Q feverCoxiella burnetiiCoxiellosisMeta-prevalencePCRIS1111 |
| spellingShingle | Ana Rabaza Martín Fraga Luis Gustavo Corbellini Katy M.E. Turner Franklin Riet-Correa Mark C. Eisler Molecular prevalence of Coxiella burnetii in bulk-tank milk from bovine dairy herds: Systematic review and meta-analysis One Health Q fever Coxiella burnetii Coxiellosis Meta-prevalence PCR IS1111 |
| title | Molecular prevalence of Coxiella burnetii in bulk-tank milk from bovine dairy herds: Systematic review and meta-analysis |
| title_full | Molecular prevalence of Coxiella burnetii in bulk-tank milk from bovine dairy herds: Systematic review and meta-analysis |
| title_fullStr | Molecular prevalence of Coxiella burnetii in bulk-tank milk from bovine dairy herds: Systematic review and meta-analysis |
| title_full_unstemmed | Molecular prevalence of Coxiella burnetii in bulk-tank milk from bovine dairy herds: Systematic review and meta-analysis |
| title_short | Molecular prevalence of Coxiella burnetii in bulk-tank milk from bovine dairy herds: Systematic review and meta-analysis |
| title_sort | molecular prevalence of coxiella burnetii in bulk tank milk from bovine dairy herds systematic review and meta analysis |
| topic | Q fever Coxiella burnetii Coxiellosis Meta-prevalence PCR IS1111 |
| url | http://www.sciencedirect.com/science/article/pii/S2352771420303098 |
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