Korelasi Ekspresi Reseptor Vitamin D (VDR) dengan Derajat Diferensiasi dan Stadium Adenokarsinoma Kolorektal
Colorectal carcinoma (CRC) is a malignancy from mucosal epithelium of the colon/rectum. The treatment modalities used for advance stage colorectal carcinoma therapy is chemotherapy, in addition to surgery. Targeted therapy is currently being developed as an alternative therapy. One of the agents use...
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| Format: | Article |
| Language: | English |
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Universitas Padjajaran
2016-06-01
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| Series: | Majalah Kedokteran Bandung |
| Subjects: | |
| Online Access: | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/387 |
| _version_ | 1819122598821232640 |
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| author | Hermin Aminah Usman Yulie Erida Herry Yulianti Abdul Hadi Hassan |
| author_facet | Hermin Aminah Usman Yulie Erida Herry Yulianti Abdul Hadi Hassan |
| author_sort | Hermin Aminah Usman |
| collection | DOAJ |
| description | Colorectal carcinoma (CRC) is a malignancy from mucosal epithelium of the colon/rectum. The treatment modalities used for advance stage colorectal carcinoma therapy is chemotherapy, in addition to surgery. Targeted therapy is currently being developed as an alternative therapy. One of the agents used in this therapy is calcitriol. Calcitriol is an active metabolite of vitamin D. Calcitriol works synergistically with chemotherapeutic agents and its activity is mediated by the vitamin D receptor (VDR). VDR plays a role in the inhibition of tumor progression via induction of cellular differentiation and proliferation inhibition. In this study, imunoexpression of vitamin D receptor was examined in conjunction with the staging and degree of differentiation (grading) of colorectal adenocarcinoma. The study objects include 35 colorectal adenocarcinoma paraffin blocks created from colectomy which were collected at the Department of Patology Anatomic of Dr. Hasan Sadikin General Hospital Bandung from January 2009–June 2014. The blocks were divided into three groups of staging (I, II, and III) and three groups of grading: well, moderately, and poorly differentiated. Immunostaining was used to evaluate the VDR immunoexspression by histo-score. The data were tested using rank spearman test. There was a weak negative correlation between VDR imunoexpression and staging(p=0.045, R=-0.341), and a moderate positive correlation between VDR imunoexpression and grading (p=0.000, R=0.558). It is concluded that a significant correlation of VDR imunoexpression with staging and grading of colorectal adenocarcinoma is found and this finding can be used as a reference for further studies in the development of targeted therapies. |
| first_indexed | 2024-12-22T06:55:00Z |
| format | Article |
| id | doaj.art-1e9d2aacb4bb42808c1be540e139ef34 |
| institution | Directory Open Access Journal |
| issn | 0126-074X 0126-074X |
| language | English |
| last_indexed | 2024-12-22T06:55:00Z |
| publishDate | 2016-06-01 |
| publisher | Universitas Padjajaran |
| record_format | Article |
| series | Majalah Kedokteran Bandung |
| spelling | doaj.art-1e9d2aacb4bb42808c1be540e139ef342022-12-21T18:34:59ZengUniversitas PadjajaranMajalah Kedokteran Bandung0126-074X0126-074X2016-06-0148212312810.15395/mkb.v48n2.387Korelasi Ekspresi Reseptor Vitamin D (VDR) dengan Derajat Diferensiasi dan Stadium Adenokarsinoma KolorektalHermin Aminah Usman0Yulie Erida1Herry Yulianti2Abdul Hadi Hassan3Departemen Patologi Anatomi Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Dr. Hasan Sadikin BandungDepartemen Patologi Anatomi Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Dr. Hasan Sadikin BandungDepartemen Patologi Anatomi Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Dr. Hasan Sadikin BandungDepartemen Patologi Anatomi Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Dr. Hasan Sadikin BandungColorectal carcinoma (CRC) is a malignancy from mucosal epithelium of the colon/rectum. The treatment modalities used for advance stage colorectal carcinoma therapy is chemotherapy, in addition to surgery. Targeted therapy is currently being developed as an alternative therapy. One of the agents used in this therapy is calcitriol. Calcitriol is an active metabolite of vitamin D. Calcitriol works synergistically with chemotherapeutic agents and its activity is mediated by the vitamin D receptor (VDR). VDR plays a role in the inhibition of tumor progression via induction of cellular differentiation and proliferation inhibition. In this study, imunoexpression of vitamin D receptor was examined in conjunction with the staging and degree of differentiation (grading) of colorectal adenocarcinoma. The study objects include 35 colorectal adenocarcinoma paraffin blocks created from colectomy which were collected at the Department of Patology Anatomic of Dr. Hasan Sadikin General Hospital Bandung from January 2009–June 2014. The blocks were divided into three groups of staging (I, II, and III) and three groups of grading: well, moderately, and poorly differentiated. Immunostaining was used to evaluate the VDR immunoexspression by histo-score. The data were tested using rank spearman test. There was a weak negative correlation between VDR imunoexpression and staging(p=0.045, R=-0.341), and a moderate positive correlation between VDR imunoexpression and grading (p=0.000, R=0.558). It is concluded that a significant correlation of VDR imunoexpression with staging and grading of colorectal adenocarcinoma is found and this finding can be used as a reference for further studies in the development of targeted therapies.http://journal.fk.unpad.ac.id/index.php/mkb/article/view/387Adenocarcinoma colorectalgradingstagingVDR imunoexpression |
| spellingShingle | Hermin Aminah Usman Yulie Erida Herry Yulianti Abdul Hadi Hassan Korelasi Ekspresi Reseptor Vitamin D (VDR) dengan Derajat Diferensiasi dan Stadium Adenokarsinoma Kolorektal Majalah Kedokteran Bandung Adenocarcinoma colorectal grading staging VDR imunoexpression |
| title | Korelasi Ekspresi Reseptor Vitamin D (VDR) dengan Derajat Diferensiasi dan Stadium Adenokarsinoma Kolorektal |
| title_full | Korelasi Ekspresi Reseptor Vitamin D (VDR) dengan Derajat Diferensiasi dan Stadium Adenokarsinoma Kolorektal |
| title_fullStr | Korelasi Ekspresi Reseptor Vitamin D (VDR) dengan Derajat Diferensiasi dan Stadium Adenokarsinoma Kolorektal |
| title_full_unstemmed | Korelasi Ekspresi Reseptor Vitamin D (VDR) dengan Derajat Diferensiasi dan Stadium Adenokarsinoma Kolorektal |
| title_short | Korelasi Ekspresi Reseptor Vitamin D (VDR) dengan Derajat Diferensiasi dan Stadium Adenokarsinoma Kolorektal |
| title_sort | korelasi ekspresi reseptor vitamin d vdr dengan derajat diferensiasi dan stadium adenokarsinoma kolorektal |
| topic | Adenocarcinoma colorectal grading staging VDR imunoexpression |
| url | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/387 |
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