Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus?
Abstract Background Childhood-onset systemic lupus erythematosus (c-SLE) is a chronic autoimmune disease which increases cardiovascular risk factors (CRF) such as elevated homocysteine, TNF-α, and hs-C reactive protein. Methods We evaluated BMI, waist circumference (WC), 24-h recalls, SLEDAI-2 K, SL...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-01-01
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| Series: | Pediatric Rheumatology Online Journal |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12969-017-0220-y |
| _version_ | 1818067804314664960 |
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| author | Roberta Garcia Salomão Luciana Martins de Carvalho Clarice Izumi Érika Silva Czernisz José César Rosa Sonir Roberto Rauber Antonini Ana Carolina Bueno Maria Olímpia Ribeiro do Vale Almada Carolina de Almeida Coelho-Landell Alceu Afonso Jordão Virgínia Paes Leme Ferriani Jacqueline Pontes Monteiro |
| author_facet | Roberta Garcia Salomão Luciana Martins de Carvalho Clarice Izumi Érika Silva Czernisz José César Rosa Sonir Roberto Rauber Antonini Ana Carolina Bueno Maria Olímpia Ribeiro do Vale Almada Carolina de Almeida Coelho-Landell Alceu Afonso Jordão Virgínia Paes Leme Ferriani Jacqueline Pontes Monteiro |
| author_sort | Roberta Garcia Salomão |
| collection | DOAJ |
| description | Abstract Background Childhood-onset systemic lupus erythematosus (c-SLE) is a chronic autoimmune disease which increases cardiovascular risk factors (CRF) such as elevated homocysteine, TNF-α, and hs-C reactive protein. Methods We evaluated BMI, waist circumference (WC), 24-h recalls, SLEDAI-2 K, SLICC/ACR-DI, serum levels of homocysteine, folate, TNF-α, hs-C reactive protein, lipid profile, proteomic data, and duration of corticosteroid therapy in 19 c-SLE and 38 healthy volunteers. Physiological and anthropometric variables of c-SLE and healthy controls were compared by ANCOVA. k-cluster was used to separate c-SLE into two different groups with the best and the worst metabolic profile according to previous analysis showing some metabolites that were statistically different from controls, such as homocysteine, TNF-α, hs-CRP and folate levels. These two clusters were again compared with the control group regarding nutritional parameters, lipid profile and also proteomic data. Results Individuals with c-SLE presented higher BMI, WC, homocysteine, triglycerides, TNF-α, hs-CRP and lower folate levels when compared to controls. We found 10 proteins whose relative abundances were statistically different between control group and lupus clusters with the best (LCBMP) and the worst metabolic profile (LCWMP). A significant positive correlation was found between TNF-α and triglycerides and between hs-CRP and duration of corticosteroid therapy. Conclusion Cardiovascular disease (CVD) risk parameters were worse in c-SLE. A less protective CVD proteomic profile was found in LCWMP. |
| first_indexed | 2024-12-10T15:29:30Z |
| format | Article |
| id | doaj.art-1e9e1cd9adbc48ad846261ea8dd4b861 |
| institution | Directory Open Access Journal |
| issn | 1546-0096 |
| language | English |
| last_indexed | 2024-12-10T15:29:30Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Pediatric Rheumatology Online Journal |
| spelling | doaj.art-1e9e1cd9adbc48ad846261ea8dd4b8612022-12-22T01:43:25ZengBMCPediatric Rheumatology Online Journal1546-00962018-01-011611810.1186/s12969-017-0220-yHomocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus?Roberta Garcia Salomão0Luciana Martins de Carvalho1Clarice Izumi2Érika Silva Czernisz3José César Rosa4Sonir Roberto Rauber Antonini5Ana Carolina Bueno6Maria Olímpia Ribeiro do Vale Almada7Carolina de Almeida Coelho-Landell8Alceu Afonso Jordão9Virgínia Paes Leme Ferriani10Jacqueline Pontes Monteiro11Department of Pediatrics, Ribeirão Preto Medical School, University of São PauloDepartment of Pediatrics, Ribeirão Preto Medical School, University of São PauloProtein Chemistry Center, Ribeirão Preto Medical School, University of São PauloProtein Chemistry Center, Ribeirão Preto Medical School, University of São PauloProtein Chemistry Center, Ribeirão Preto Medical School, University of São PauloDepartment of Pediatrics, Ribeirão Preto Medical School, University of São PauloDepartment of Pediatrics, Ribeirão Preto Medical School, University of São PauloDepartment of Pediatrics, Ribeirão Preto Medical School, University of São PauloDepartment of Pediatrics, Ribeirão Preto Medical School, University of São PauloDepartment of Medical Clinical, Ribeirão Preto Medical School, University of São PauloDepartment of Pediatrics, Ribeirão Preto Medical School, University of São PauloDepartment of Pediatrics, Ribeirão Preto Medical School, University of São PauloAbstract Background Childhood-onset systemic lupus erythematosus (c-SLE) is a chronic autoimmune disease which increases cardiovascular risk factors (CRF) such as elevated homocysteine, TNF-α, and hs-C reactive protein. Methods We evaluated BMI, waist circumference (WC), 24-h recalls, SLEDAI-2 K, SLICC/ACR-DI, serum levels of homocysteine, folate, TNF-α, hs-C reactive protein, lipid profile, proteomic data, and duration of corticosteroid therapy in 19 c-SLE and 38 healthy volunteers. Physiological and anthropometric variables of c-SLE and healthy controls were compared by ANCOVA. k-cluster was used to separate c-SLE into two different groups with the best and the worst metabolic profile according to previous analysis showing some metabolites that were statistically different from controls, such as homocysteine, TNF-α, hs-CRP and folate levels. These two clusters were again compared with the control group regarding nutritional parameters, lipid profile and also proteomic data. Results Individuals with c-SLE presented higher BMI, WC, homocysteine, triglycerides, TNF-α, hs-CRP and lower folate levels when compared to controls. We found 10 proteins whose relative abundances were statistically different between control group and lupus clusters with the best (LCBMP) and the worst metabolic profile (LCWMP). A significant positive correlation was found between TNF-α and triglycerides and between hs-CRP and duration of corticosteroid therapy. Conclusion Cardiovascular disease (CVD) risk parameters were worse in c-SLE. A less protective CVD proteomic profile was found in LCWMP.http://link.springer.com/article/10.1186/s12969-017-0220-yProteomicNutritional statusHomocysteineFolic acidTumor necrosis factor alphaChildhood onset systemic lupus Erythematosus |
| spellingShingle | Roberta Garcia Salomão Luciana Martins de Carvalho Clarice Izumi Érika Silva Czernisz José César Rosa Sonir Roberto Rauber Antonini Ana Carolina Bueno Maria Olímpia Ribeiro do Vale Almada Carolina de Almeida Coelho-Landell Alceu Afonso Jordão Virgínia Paes Leme Ferriani Jacqueline Pontes Monteiro Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus? Pediatric Rheumatology Online Journal Proteomic Nutritional status Homocysteine Folic acid Tumor necrosis factor alpha Childhood onset systemic lupus Erythematosus |
| title | Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus? |
| title_full | Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus? |
| title_fullStr | Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus? |
| title_full_unstemmed | Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus? |
| title_short | Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus? |
| title_sort | homocysteine folate hs c reactive protein tumor necrosis factor alpha and inflammatory proteins are these biomarkers related to nutritional status and cardiovascular risk in childhood onset systemic lupus erythematosus |
| topic | Proteomic Nutritional status Homocysteine Folic acid Tumor necrosis factor alpha Childhood onset systemic lupus Erythematosus |
| url | http://link.springer.com/article/10.1186/s12969-017-0220-y |
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