SIFamide Translates Hunger Signals into Appetitive and Feeding Behavior in Drosophila
Animal behavior is, on the one hand, controlled by neuronal circuits that integrate external sensory stimuli and induce appropriate motor responses. On the other hand, stimulus-evoked or internally generated behavior can be influenced by motivational conditions, e.g., the metabolic state. Motivation...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-07-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124717308574 |
| _version_ | 1828397124894588928 |
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| author | Carlotta Martelli Ulrike Pech Simon Kobbenbring Dennis Pauls Britta Bahl Mirjam Vanessa Sommer Atefeh Pooryasin Jonas Barth Carmina Warth Perez Arias Chrystalleni Vassiliou Abud Jose Farca Luna Haiko Poppinga Florian Gerhard Richter Christian Wegener André Fiala Thomas Riemensperger |
| author_facet | Carlotta Martelli Ulrike Pech Simon Kobbenbring Dennis Pauls Britta Bahl Mirjam Vanessa Sommer Atefeh Pooryasin Jonas Barth Carmina Warth Perez Arias Chrystalleni Vassiliou Abud Jose Farca Luna Haiko Poppinga Florian Gerhard Richter Christian Wegener André Fiala Thomas Riemensperger |
| author_sort | Carlotta Martelli |
| collection | DOAJ |
| description | Animal behavior is, on the one hand, controlled by neuronal circuits that integrate external sensory stimuli and induce appropriate motor responses. On the other hand, stimulus-evoked or internally generated behavior can be influenced by motivational conditions, e.g., the metabolic state. Motivational states are determined by physiological parameters whose homeostatic imbalances are signaled to and processed within the brain, often mediated by modulatory peptides. Here, we investigate the regulation of appetitive and feeding behavior in the fruit fly, Drosophila melanogaster. We report that four neurons in the fly brain that release SIFamide are integral elements of a complex neuropeptide network that regulates feeding. We show that SIFamidergic cells integrate feeding stimulating (orexigenic) and feeding suppressant (anorexigenic) signals to appropriately sensitize sensory circuits, promote appetitive behavior, and enhance food intake. Our study advances the cellular dissection of evolutionarily conserved signaling pathways that convert peripheral metabolic signals into feeding-related behavior. |
| first_indexed | 2024-12-10T08:42:23Z |
| format | Article |
| id | doaj.art-1e9e77379a6b42cb88dfd265cec21c54 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-10T08:42:23Z |
| publishDate | 2017-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-1e9e77379a6b42cb88dfd265cec21c542022-12-22T01:55:49ZengElsevierCell Reports2211-12472017-07-0120246447810.1016/j.celrep.2017.06.043SIFamide Translates Hunger Signals into Appetitive and Feeding Behavior in DrosophilaCarlotta Martelli0Ulrike Pech1Simon Kobbenbring2Dennis Pauls3Britta Bahl4Mirjam Vanessa Sommer5Atefeh Pooryasin6Jonas Barth7Carmina Warth Perez Arias8Chrystalleni Vassiliou9Abud Jose Farca Luna10Haiko Poppinga11Florian Gerhard Richter12Christian Wegener13André Fiala14Thomas Riemensperger15Molecular Neurobiology of Behavior, Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, University of Goettingen, Julia-Lermontowa-Weg 3, 37077 Goettingen, GermanyMolecular Neurobiology of Behavior, Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, University of Goettingen, Julia-Lermontowa-Weg 3, 37077 Goettingen, GermanyMolecular Neurobiology of Behavior, Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, University of Goettingen, Julia-Lermontowa-Weg 3, 37077 Goettingen, GermanyNeurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, GermanyMolecular Neurobiology of Behavior, Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, University of Goettingen, Julia-Lermontowa-Weg 3, 37077 Goettingen, GermanyMolecular Neurobiology of Behavior, Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, University of Goettingen, Julia-Lermontowa-Weg 3, 37077 Goettingen, GermanyMolecular Neurobiology of Behavior, Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, University of Goettingen, Julia-Lermontowa-Weg 3, 37077 Goettingen, GermanyMolecular Neurobiology of Behavior, Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, University of Goettingen, Julia-Lermontowa-Weg 3, 37077 Goettingen, GermanyMolecular Neurobiology of Behavior, Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, University of Goettingen, Julia-Lermontowa-Weg 3, 37077 Goettingen, GermanyMolecular Neurobiology of Behavior, Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, University of Goettingen, Julia-Lermontowa-Weg 3, 37077 Goettingen, GermanyMolecular Neurobiology of Behavior, Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, University of Goettingen, Julia-Lermontowa-Weg 3, 37077 Goettingen, GermanyMolecular Neurobiology of Behavior, Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, University of Goettingen, Julia-Lermontowa-Weg 3, 37077 Goettingen, GermanyNeurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, GermanyNeurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, GermanyMolecular Neurobiology of Behavior, Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, University of Goettingen, Julia-Lermontowa-Weg 3, 37077 Goettingen, GermanyMolecular Neurobiology of Behavior, Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, University of Goettingen, Julia-Lermontowa-Weg 3, 37077 Goettingen, GermanyAnimal behavior is, on the one hand, controlled by neuronal circuits that integrate external sensory stimuli and induce appropriate motor responses. On the other hand, stimulus-evoked or internally generated behavior can be influenced by motivational conditions, e.g., the metabolic state. Motivational states are determined by physiological parameters whose homeostatic imbalances are signaled to and processed within the brain, often mediated by modulatory peptides. Here, we investigate the regulation of appetitive and feeding behavior in the fruit fly, Drosophila melanogaster. We report that four neurons in the fly brain that release SIFamide are integral elements of a complex neuropeptide network that regulates feeding. We show that SIFamidergic cells integrate feeding stimulating (orexigenic) and feeding suppressant (anorexigenic) signals to appropriately sensitize sensory circuits, promote appetitive behavior, and enhance food intake. Our study advances the cellular dissection of evolutionarily conserved signaling pathways that convert peripheral metabolic signals into feeding-related behavior.http://www.sciencedirect.com/science/article/pii/S2211124717308574Drosophila melanogasterSIFamidehugin-PKfeeding behavior |
| spellingShingle | Carlotta Martelli Ulrike Pech Simon Kobbenbring Dennis Pauls Britta Bahl Mirjam Vanessa Sommer Atefeh Pooryasin Jonas Barth Carmina Warth Perez Arias Chrystalleni Vassiliou Abud Jose Farca Luna Haiko Poppinga Florian Gerhard Richter Christian Wegener André Fiala Thomas Riemensperger SIFamide Translates Hunger Signals into Appetitive and Feeding Behavior in Drosophila Cell Reports Drosophila melanogaster SIFamide hugin-PK feeding behavior |
| title | SIFamide Translates Hunger Signals into Appetitive and Feeding Behavior in Drosophila |
| title_full | SIFamide Translates Hunger Signals into Appetitive and Feeding Behavior in Drosophila |
| title_fullStr | SIFamide Translates Hunger Signals into Appetitive and Feeding Behavior in Drosophila |
| title_full_unstemmed | SIFamide Translates Hunger Signals into Appetitive and Feeding Behavior in Drosophila |
| title_short | SIFamide Translates Hunger Signals into Appetitive and Feeding Behavior in Drosophila |
| title_sort | sifamide translates hunger signals into appetitive and feeding behavior in drosophila |
| topic | Drosophila melanogaster SIFamide hugin-PK feeding behavior |
| url | http://www.sciencedirect.com/science/article/pii/S2211124717308574 |
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